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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three different microcomputers proved to be useful in processing of pressure, flow and volume signals during cough and other respiratory manoeuvres. In young healthy volunteers, values of forced vital capacity, peak expiratory flow and flow at 0.1 s measured during cough were smaller in women than in men due to their smaller body surface and FVC. Compared to forced expiration a sudden and vigorous cough effort, in spite of its shorter duration, resulted in an increased mean flow rate and in similar peak flow reached by expulsion of a smaller volume. Analysis of flow-volume curves indicated higher flow-rates at the beginning (5-10% FEV) and to the end of cough expulsion (65-95% FEV) than in forced expiration. The volume, peak flow and flow 0.1 s from the beginning of inspiration and expiration were practically the same in 5 successive cycles of voluntary cough performed by maximum effort. The mechanisms involved in cough expiration are more automatic than the mechanisms of cough inspiration. A personal computer can be useful for monitoring the increase in PEP, PIP, PEF, PIF, FEV, FIV and in maximum resistance as well as the decrease in compliance observed during cough compared to quiet breathing.
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PMID:Computer-assisted evaluation of some respiratory parameters during voluntary cough. 343 3

Patients who have chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA) share symptoms such as, dyspnoea, cough and wheeze. Differentiating these diseases in the ambulatory setting can be challenging especially in older adult smokers who are being treated with a variety of medications. The objective of this study was to test the value of adding a maximal inspiratory manoeuvre to basic spirometry to differentiate COPD and BA. One hundred forty-three COPD patients and 142 BA patients had measurements of maximal inspiratory and expiratory flow during routine spirometry. Parameters from these tests were used to assess diagnostic accuracy using receiver-operating characteristic (ROC) analyses followed by logistic regression. The association of two independent parameters were analyzed using linear regression analyses. Results show that forced expiratory volume in one second/forced vital capacity (FEV1/FVC%) <62.4 was the best independent predictor to diagnose COPD. The combination of FEV1/FVC% <62.4 and the ratio of peak inspiratory flow/maximal expiratory flow at 50% FVC (PIF/MEF50) >3.06 significantly predicted COPD. Post-test probability for prediction of COPD was 82.0% when patients had both parameters. When asthmatic patients with a smoking history were compared with COPD patients, FEV1/FVC% <63.4 and PIF/MEF50 >3.29 were both independent predictors of COPD. The post-test probability for COPD was 94.4% when patients had both parameters. The association between FEV1/FVC% and PIF/MEF50 was significantly different between COPD and BA. In conclusion, the addition of the maximal inspiratory effort to routine pulmonary function measurements provides a simple test to help differentiate COPD and BA.
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PMID:Ratio of Maximal Inspiratory to Expiratory Flow Aids in the Separation of COPD from Asthma. 3250 52