Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From February 1965 to April 1993, 88 patients with middle lobe carcinoma of the lung were treated surgically. It constituted 7.7% of the total patients of operated lung cancer in our hospital. Clinical symptoms were mainly fever, cough, bloody-sputum and chest pain. 84 of 88 patients were treated by wedge resection, lobectomy and pneumonectomy. Exploration was preformed in 4 patients. The 1, 3, 5 and 10-year survival rates of the 78 patients followed up were 87.18%, 43.08%, 38.18% and 24.13% respectively. It related to four clinical features of middle lobe cancer of the lung were treated surgically is discussed.
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PMID:[Surgical treatment of middle lobe carcinoma of the lung]. 777 24

A 51-year-old man was admitted to our hospital with a chief complaint of cough. His chest X-ray and CT scan revealed enlargement of a left hilar lymph node. However, no primary lesion was apparent in the rest of the lung. Bronchofiberscopic findings were essentially normal. At surgery the mass was determined to be an enlarged lymph node (No. 11). No apparent malignant lesion was identified in the lung. Postoperative pathological examination showed small cell carcinoma in a part of the No. 11 lymph node. Despite a thorough systemic examination, no primary foci were detected. We have been following up this patient with chemotherapy for the approximately 2 year period since the operation, but no primary lesions have been detected as yet. Therefore, we speculate that this patient is a very rare case of primary unknown T0N1M0 lung cancer.
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PMID:[A suspected case of T0N1M0 small cell carcinoma of the lung]. 780 64

Hamartoma is one of the most common benign tumors in the lung, and most of the lung hamartomas are located in the parenchyma. This report reviews 24 cases with this kind of tumor. The male-female ratio was 1.4:1 and the mean age 46.4 years. Sixteen patients of the 24 were asymptomatic, while in the remainder cases chest pain or distress, cough, short breath or hemoptysis were presented. Lung hamartoma is usually composed of cartilage, fat, smooth muscle and respiratory epithelium. X-ray findings of the parenchymal type in these cases were characterized by a round or oval sharply outlined mass, but only one with a mass in the shape of a dumbbell. 33% cases showed calcification. In 19 cases the mass was < 3.0 cm diameter (79%) and in 17 it was located in the superficial edge of the lung. The diagnosis was confirmed in only 6 cases preoperatively. The other cases were misdiagnosed as lung cancer, tuberculoma, metastatic tumors of the lung, etc. Enucleation or wedge resection is desirable for this kind of tumor.
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PMID:[Hamartoma of the lung: an analysis of 24 cases]. 799 73

It is proposed to make a qualitative analysis of one of the most frequent bronchopulmonary symptoms--cough. This involves dynamic tussographic evaluation of the cough and expectoration in the original inulin test. The analysis covered such cough characteristics as resistance, efficacy, intensity, volleys assessed in patients with lung cancer, chronic bronchitis, tracheobronchial dyskinesia. Typical changes in the above indices observed in each of the patient groups have been defined which are essential for diagnosis and differential diagnosis.
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PMID:[The clinico-diagnostic significance of qualitative cough indices in nonspecific lung diseases]. 805 10

The EORTC Study Group on Quality of Life has developed a modular system for assessing the quality of life of cancer patients in clinical trials composed of two basic elements: (1) a core quality of life questionnaire, the EORTC QLQ-C30, covering general aspects of health-related quality of life, and (2) additional disease- or treatment-specific questionnaire modules. Two international field studies were carried out to evaluate the practicality, reliability and validity of the core questionnaire, supplemented by a 13-item lung cancer-specific questionnaire module, the EORTC QLQ-LC13. In this paper, the results of an evaluation of the QLQ-LC13 are reported. The lung cancer questionnaire module comprises both multi-item and single-item measures of lung cancer-associated symptoms (i.e. coughing, haemoptysis, dyspnoea and pain) and side-effects from conventional chemo- and radiotherapy (i.e. hair loss, neuropathy, sore mouth and dysphagia). It was administered to patients with non-resectable lung cancer recruited from 17 countries. In total, 883 and 735 patients, respectively, completed the questionnaire prior to and once during treatment. The symptom measures discriminated clearly between patients differing in performance status. All item scores changed significantly in the expected direction (i.e. lung cancer symptoms decreased and treatment toxicities increased) during treatment. With one exception (problems with a sore mouth), the change of toxicity measures over time was related specifically to either chemo- or radiotherapy. However, the single item on neuropathy did not measure adequately the full range of symptoms. The hypothesised scale structure of the questionnaire was partially supported by the data. The multi-item dyspnoea scale met the minimal standards for reliability (Cronbach alpha coefficient > 0.70), while the pain items did not form a scale with reliability estimates acceptable for group comparisons. In conclusion, the results form international field testing lend support to the EORTC QLQ-LC13 as a clinically valid and useful tool for assessing disease- and treatment-specific symptoms in lung cancer patients participating in clinical trials, when combined with the EORTC core quality of life questionnaire. In a few areas, however, the questionnaire module could benefit from further refinements. In addition, its performance over a longer period of time still needs to be investigated.
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PMID:The EORTC QLQ-LC13: a modular supplement to the EORTC Core Quality of Life Questionnaire (QLQ-C30) for use in lung cancer clinical trials. EORTC Study Group on Quality of Life. 808 Jun 79

A 60-year-old male complaining cough was referred to our hospital. His chest roentgenogram showed left hilar abnormal shadow and his sputum cytology was reported to be class V. Bronchoscopy revealed a squamous cell carcinoma of the orifice of the left B6. It suggested early hilar carcinoma with obstructive pneumonia. We performed sleeve segmentectomy of the S6 with bronchoplastic procedure. Bronchial wall invasion of squamous cell carcinoma was observed histologically and it was confirmed as early hilar lung cancer. His postoperative course was uneventful and no evidence of recurrence is observed 12 months after operation. Patency of the basal bronchus is excellent and his vital capacity and forced expiratory volume in one second are almost equal to preoperative values. In such early hilar lung cancer that occupied the orifice of the B6, the margin of oral side bronchus resected by sleeve S6 segmentectomy is almost same as by lower lobectomy. We believed that this procedure can be minimum invasive standard operation in such cases.
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PMID:[Sleeve S6 segmentectomy for early bronchial squamous cell carcinoma--a case report]. 808 73

A case of sarcoidosis with a high level of SCC antigen in the serum and broncho-alveolar lavage fluid (BALF) which was difficult to distinguish from lung cancer is reported. A 66-year-old female was admitted with a fever, sputum and coughing. Chest X-ray on admission showed bilateral hilar swelling and infiltrative shadows in the left lower lung. Chest CT showed bilateral lymph node enlargement and a localized nodular mass. The level of SCC antigen in the serum and BALF was high. Initially she was suspected of having lung cancer, but she was subsequently diagnosed as having sarcoidosis from a bronchial biopsy specimen, BALF and gallium scintigraphy. It was difficult to distinguish this case showing lymph node enlargement and mass shadow from lung cancer. Although this is a rarely reported case of sarcoidosis with a high level of SCC antigen in the serum and BALF, it is possible that SCC antigen may be elevated in patients with benign inflammatory lung disease due to various interactions of cytokines.
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PMID:[A case of sarcoidosis with elevated SCC antigen in the serum and broncho-alveolar lavage fluid which was difficult to distinguish from lung cancer]. 811 81

We reported two cases of idiopathic interstitial pneumonia (IIP) who developed acute exacerbation after bronchoalveolar lavage (BAL). One case was a 67-year-old male who presented with dry cough and exertional dyspnea. He was diagnosed as IIP and transbronchial lung biopsy revealed alveolitis. BAL was performed after administration of prednisolone. He complained of severe dyspnea after BAL and was diagnosed as having an acute exacerbation of IIP. In spite of extensive treatment including pulse therapy with methylprednisolone, he died. The other case was a 57-year-old male noted to have a chest X-ray abnormality who presented with dry cough and dyspnea on exertion. He was diagnosed as having IIP and primary lung cancer. BAL was performed to evaluate the activity of IIP, and respiratory distress subsequently became severe. After BAL, he developed an acute exacerbation of IIP and died in spite of treatment. In both cases, peripheral white blood cell counts were increased just before BAL. It was suggested that this condition might participate in acute exacerbation of IIP. It should be kept in mind that some patients with IIP may develop acute exacerbation after BAL.
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PMID:[Two cases of IIP which developed acute exacerbation after bronchoalveolar lavage]. 816 6

A 72-year-old female was admitted with complaints of cough and sputum. The chest X-ray film revealed a solitary round mass and pleural effusion in the left lower lung field. Laboratory tests demonstrated elevated levels of serum HCG and beta-HCG. Left lower lobectomy with parietal pleurectomy was performed under the diagnosis of primary lung cancer with malignant effusion. The serum HCG level decreased after the operation. Histologically, the tumor was diagnosed as moderately differentiated papillo-tubular adenocarcinoma of the lung. In the HCG staining using an immunohistochemical method, the tumor cells showed a positive reaction. Thus, this tumor was definitively diagnosed to be HCG-producing adenocarcinoma of the lung.
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PMID:[A female case of adenocarcinoma of the lung producing human chorionic gonadotropin]. 820 92

A rare case of metastatic lung cancer presenting with multiple thin-walled cavity-like shadows in a young adult with gallbladder cancer is reported. A 30-year-old man consulted our hospital with fever, cough, and general malaise. His chest X-ray film and computed tomogram showed multiple nodular shadows and thin-walled cavity-like shadows. Cytology of sputum and bronchoalveolar lavage fluid showed class V (adenocarcinoma). Although two cycles of systemic combination chemotherapy (CDDP+VDS+MMC) were performed, his lung cancer progressed. Finally, he died of obstructive jaundice from lymph node metastasis at the pancreatic head. At autopsy, the primary site of adenocarcinoma was found to be the gallbladder. Metastatic lung tumor from gallbladder cancer is common, and thin-walled cavity-like metastasis to the lung in a young adult is a rare occurrence.
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PMID:[Metastatic lung cancer presenting with multiple thin-walled cavity-like shadows in a young adult with gallbladder cancer]. 823 Aug 86


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