Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mucoepidermoid carcinoma is the rarest presentation in children arising from bronchial glands with low potential for malignancy as most of children have history of recurrent chest infections. We present the case of ten years old girl presenting with history of recurrent respiratory infections in past admitted for fever, cough and respiratory distress. HRCT showed soft tissue in lumen of trachea at level of carina extending into right main bronchus along with collapse of apical segment of right upper lobe and right middle and lower lobes collapse consolidation. Surgery was done and histopathology showed low grade mucoepidermoid carcinoma with clear histopathology of regional lymph nodes. Follow up of patient done for two years. Informed consent was taken from patient prior to writing of this case report.
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PMID:Mucoepidermoid Carcinoma - Rare Presentation Of Childhood Chronic Respiratory Symptoms In 10 Years Old Girl. 3258 10

Mucoepidermoid carcinoma (MEC) of the lung is an extremely rare tumor, and a standard chemotherapy has not been established. Furthermore, little work has been conducted on the genetic characteristics of MEC. We herein report the case of a 42-year-old nonsmoking male patient who was referred to our hospital due to cough. Chest computed tomography demonstrated infiltration and atelectasis in the right lower lobe. He was eventually diagnosed with non-small cell lung cancer (NSCLC) with MEC differentiation corresponding to clinical stage IVA (cT4N2M1a[PLE]). Genetic testing for EGFR mutations was negative, but positive for anaplastic lymphoma kinase (ALK) fusion gene. After 2 weeks of first-line treatment with alectinib, the tumor decreased in size and his symptoms improved. Advanced MEC is a rare tumor, and reports on the treatment of ALK-positive NSCLC with MEC differentiation are rare.
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PMID:Anaplastic Lymphoma Kinase-Positive Lung Cancer with Mucoepidermoid Carcinoma Differentiation: A Case Report. 3308 45


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