Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An unusual case of illness of a 49 year old woman who suffered from inexpressive skin rash for three years is described. Repeated biopsies did not bring an unequivocal result. Then an illness followed with a short term fever, prolonged cough, and progressing dissemination of tiny focal shadows of infiltration character in both lungs. Simultaneous biopsies of the skin and excised pulmonal tissue revealed histiocytolymphocytic infiltrations of an identical character. Atypical cells which were difficult to classify were present. Dermal and pulmonal infiltrations disappeared after chemotherapy. Eruption occurred again after a year and hasty development of acute myeloid leukemia started. It was a case of prodromal myelosarcoma stage with skin and pulmonal infiltration by quite undifferentiated reticulohistiocytic elements of the myeloid line, which ended as acute myeloid leukemia after 4 years.
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PMID:Pulmonary and dermal manifestations of myelosarcoma with delayed onset of acute myeloid leukemia. 208 29

Granulocytic sarcoma is a soft tissue collection of leukemic cells. The authors describe a 4-year-old boy with M2 acute myelogenous leukemia (AML) who presented with fever, mild nonproductive cough, and hematemesis. Although he was initially diagnosed with nodular pneumonia, rapid resolution of a pulmonary infiltrate following induction chemotherapy was suggestive of a pulmonary granulocytic sarcoma. Interphase fluorescent in situ hybridization (FISH) of the lung biopsy specimen for the t(8;21)(q22;q22) translocation confirmed the retrospective diagnosis of a well-differentiated pulmonary granulocytic sarcoma. Pulmonary granulocytic sarcomas may be underrecognized in children with AML; this may delay anti-leukemic therapy and may lead to ineffective therapy if misdiagnosed as pneumonia.
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PMID:Granulocytic sarcoma presenting as pneumonia in a child with t(8;21) acute myelogenous leukemia: diagnosis by fluorescent in situ hybridization. 1521 17

Myeloid sarcoma is a tumor formed by extramedullary accumulation of myeloblasts or immature myeloid cells. These tumors can develop in lymphoid organs, bone, skin, soft tissue, and other organs, and may precede or occur concurrently with acute myeloid leukemia. This is a case of a 42-year-old man who presented with a 2-week history of cough and shortness of breath on exertion. A computed tomography (CT) scan showed a large mediastinal mass and pericardial effusion. An F-18 fluorodeoxyglucose positron emission tomography-CT scan showed intense fluorodeoxyglucose (FDG) uptake in the mediastinal mass with invasion of the parietal pericardium. Biopsy of the mediastinal mass and pericardium revealed myeloid sarcoma. The pericardial effusion was drained and the patient was treated with high-dose cytosine arabinoside (HiDAC) chemotherapy. A follow-up positron emission tomography-CT was done 2 months after the last cycle, showing poor response to therapy and significant progression of disease with invasion through the anterior chest wall. Myeloid sarcoma can be added to the differential diagnosis of F-18 FDG avid anterior mediastinal masses, as well as F-18 FDG uptake in the pericardium.
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PMID:Myeloid sarcoma presenting as an anterior mediastinal mass invading the pericardium: Serial Imaging With F-18 FDG PET/CT. 2070 48

Myeloid sarcoma is a rare extramedullary solid tumor consisting of immature myeloid cells and most commonly involving the bone, skin, lymph nodes, soft tissue, gastrointestinal tract and testis. Mediastinal myeloid sarcoma is very rare. There are two major types of myeloid sarcoma: granulocytic sarcoma and monoblastic sarcoma, according to immature cell type. Myeloid sarcoma is found in 2%-8% of patients with acute myeloid leukemia (AML). Myeloid sarcoma may develop before or concurrently with AML, or may be the initial manifestation of AML relapse in previously treated patients. Blast transformation of some form of myeloproliferative neoplasm or myelodysplastic syndrome may also manifest as myeloid sarcoma. A major differential diagnostic problem is isolated primary myeloid sarcoma without bone marrow and peripheral blood involvement, which may precede leukemic stage for months or years, and which is frequently misdiagnosed, mostly as malignant lymphoma. A case is presented of a 56-year-old female patient complaining of weakness, vertigo, dry cough and breathing difficulties. Clinical examination revealed enhanced vascular pattern on the right chest and right arm edema. Computed tomography (CT) of the thorax showed an expansive growth measuring 11 cm craniocaudally in the anterior mediastinum. Fine needle aspiration cytology of tumor mass yielded a scarcely cellular sample with individual atypical immature cells, fine chromatin structure and scarce cytoplasm with occasional granules and Auer rods. Considering the morphological, cytochemical and immunocytochemical characteristics of immature cells, the diagnosis of myeloid sarcoma was made and verified by histopathology of tumor biopsy sample. Immature cells were not found by analysis of bone marrow puncture sample, immunophenotyping of bone marrow cells and bone biopsy analysis. As immature cell proliferation was not detected in bone marrow and peripheral blood, while spread of the disease beyond the mediastinum was ruled out by imaging methods (CT, ultrasonography), it was decided to be a primary non-leukemic form of mediastinal myeloid sarcoma. Myeloid sarcoma should be taken in consideration on differential diagnosis of solid tumors because making an accurate diagnosis is necessary for timely initiation of appropriate therapy. Weakly expressed or lacking clear signs of myeloid differentiation may hamper morphological diagnosis. As isolated myeloid sarcoma is a very rare entity frequently resembling lymphoma in clinical presentation, it poses a major diagnostic challenge for both morphologists and clinicians.
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PMID:[Isolated myeloid sarcoma involving the mediastinum]. 2312 41

Myeloid sarcoma (MS) is an extramedullary myeloid neoplasm characterized by proliferation of myeloblasts which can occur in any organ or site. Bronchial and pulmonary involvement, however, is uncommon. We describe a case of bronchial MS in an 81-year-old female with a history of high-grade myelodysplastic syndrome; she was started on treatment few months before, and she presented with fever, cough and profuse hemoptysis. She was found to be pancytopenic with bilateral airspace consolidations, most notably in the right upper and lower lobes, on imaging studies. She was treated with broad-spectrum antibiotics and antifungals without much improvement in her clinical or radiological status. Ultimately, biopsy of the lung lesions showed myeloid sarcoma with concurrent Aspergillus fumigatus infection. Bronchial/pulmonary MS should be considered in the list of differential diagnoses in a patient with a history of myeloid neoplasm and presenting with respiratory related symptoms, as early administration of chemotherapy may help to improve survival rates.
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PMID:Bronchial myeloid sarcoma with concurrent Aspergillus fumigatus infection in a patient presenting with hemoptysis. 2595 40

Myeloid sarcoma is a rare entity, and cardiac involvement is even rarer. We presented here the FDG PET/CT findings of a 66-year-old man with a 3-month history of cough and progressive dyspnea. FDG PET/CT scan demonstrated nonuniform FDG uptake in the cardiac walls and pericardium. Biopsy of the heart revealed myeloid sarcoma. In addition, bone marrow biopsy demonstrated the acute myeloid leukemia.
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PMID:FDG PET/CT Findings of Intracardiac Myeloid Sarcoma. 2781 54