Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An unusual complication of benign esophagobronchial fistula, secondary to a ruptured esophageal traction diverticulum, is reported and illustrated. The patient presented with a history of chronic, recurrent bronchitis and intermittent episodes of paroxysmal attacks of coughing and strangling on the ingestion of fluids (Ono's sign). A review of the literature with emphasis on the occurrence, pathogenesis, radiographic features, and clinical implications of esophageal traction diverticula is presented.
 ...
PMID:Esophagobronchial fistula secondary to ruptured traction diverticulum. 9 87

Eight mature horses which had been affected with a moist cough for six weeks were found to have large numbers of eosinophils in tracheal mucus samples taken by transtracheal washing. These horses were kept on irrigated pasture and fed a hay-free diet. A companion yearling donkey was found to be passing Dictyocaulus arnfieldi larvae in its faeces. Two oral treatments with a dose of thiabendazole (440 mg/kg) resulted in the resolution of the clinical signs and the disappearance of eosinophils from transtracheal washings. The eosinophilic bronchitis seen in these horses was presumed to be a manifestation of prepatent D arnfieldi infestation.
 ...
PMID:An outbreak of eosinophilic bronchitis in horses possibly associated with Dictyocaulus arnfieldi infection. 15 74

A 23-year-old woman, who had suffered recurrent acute bronchitis, dyspnoea, and stridor, was found to have a tracheal stenosis and complete left main bronchus obstruction. Biopsy of the tumour showed an adenoid cystic carcinoma. After pneumonectomy the trachea was closed through tumour tissue. Two weeks later a right thoracotomy showed that a tumour had invaded the trachea from the carina up to 6 cm and the right stem bronchus for 1 cm. Under extracorporeal circulation 7.5 cm of the trachea and right bronchus were resected. A direct tracheal anastomosis was easy to perform. Spontaneous respiration with efficient coughing returned after five days. Unfortunately, one month later, high fever caused by a lung abscess developed, which provoked a massive haemoptysis with fatal outcome.
 ...
PMID:Surgical treatment of adenoid cystic carcinoma of the left main bronchus and trachea by left pneumonectomy, resection of 7.5 cm of trachea, and direct reanastomosis of right lung. 22 43

Among 200,000 infants screened for alpha 1-antitrypsin (alpha 1-AT) deficiency, 125 Pi Z, 48 Pi Z, 1Pi S-, and 2 Pi Z- children were followed up prospectively. Eleven percent of the Pi Z infants had neonatal cholestasis, and at 2 years of age three of them had cirrhosis. About 50% of the asymptomatic Pi Z and Pi Z- subjects occasionally had serum alanine aminotransferase (ALAT) levels above normal, and in 15% of them the levels were probably permanently increased during the first two years of life. Two previously healthy Pi Z children had transient symptoms of liver disease at age 2 years in connection with severe infections. The Pi SZ children had no significant clinical liver disease and only two had abnormal serum ALAT levels. Among Pi Z children up to 2 years of age the following diseases were also encountered: eight had recurrent bronchitis with wheezing, two had persistant cough (both had cirrhosis), one had severe pneumonia, one was mentally retarded, three had urinary tract infections, six had pronounced eczema, one had allergic shock, and three had congenital malformations. Among the Pi SZ children one had recurrent bronchitis, one had eczema, and one had juvenile rheumatoid arthritis. Three children, two Pi Z and one Pi SZ, have died. The Pi Z- and Pi S- subjects were healthy. In conclusion a variety of significant symptoms were observed in about 30% of the Pi Z children compared with 6% of the Pi SZ children during the first two years of life.
 ...
PMID:alpha 1-antitrypsin deficiency in early childhood. 30 15

The authors compared the results of mycologic examinations of asthmatic and control patient's throat. Fungi other than Candida were cultivated from the throat in 15% of asthmatic children and 3% of controls. In secrets from the lower respiratory tract gained by bronchoscopy, laryngoscopy, or through tracheostomy there were moulds in 34% among the asthmatics and in 15% of the other cases. Allergic respiratory tract diseases facilitate the harbouring of moulds in the respiratory tract but do not influence the presence of Candida albicans. Moulds could often be cultivated even in patient not allergic to them. However there are chronic cases caused by immun reaction to the moulds in the patients' respiratory tract. Microscopic detection of budding and branching, myceliform fungi in the secret produced by coughing supports the diagnosis of mould causing chronic asthmoid bronchitis. New peroral broad spectrum antimycotics facilitate the treatment of such cases. The authors succesfully treated some patients with Clotrimazol (Canesten, Bayer) and all cases responded well to 5-Fluorocytosan (Ancotyl, Roche).
 ...
PMID:[Mould infection causing obstructive bronchitis. Diagnostik and therapeutic approaches (author's transl)]. 32 97

A double-blind, between-patient, placebo controlled trial was carried out to investigate the effects of methylcysteine hydrochloride in patients with chronic obstructive bronchitis. After a 2-week washout period on placebo, 30 patients were allocated at random to treatment for 6 weeks with either methylcysteine (1200 mg daily in Week 1, 800 mg daily in Week 2, then 600 mg daily) or with identical placebo tablets on the same regimen. During the post-treatment period, all patients returned to a single-blind placebo regimen (6 tablets daily) for a further 14 days. Assessments were made at the start, at regular intervals during the trial, and at the end of the post-treatment period, of subjective and objective measures of clinical response, and measurements of pulmonary function and certain physico-chemical properties of sputum. The results showed that methylcysteine increased sputum volume, reduced the viscidity of sputum, and significantly improved the subjective assessments of ease of expectoration and severity and frequency of cough, leading to a definite improvement in the patients' clinical state. No side-effects of clinical significance were reported and no abnormalities were found in any of the haematological, hepatic and renal function tests carried out.
 ...
PMID:Clinical therapeutic evaluation of methylcysteine hydrochloride in patients with chronic obstructive bronchitis: a balanced double-blind trial with placebo control. 35 Apr 98

For many years there has been much argument whether workers in the dusty trades are prone to chronic bronchitis. In 1966 the Medical Research Council issued a report of a Select Committee which concluded that occupationally induced bronchitis did not play a significant part in the aetiology of airways obstruction in dust-exposed men. Since then epidemiological studies have demonstrated that the prolonged inhalation of dust leads to an increase in prevalence of cough and sputum. Furthermore, new physiological techniques have demonstrated a slight decrement in ventilatory capacity as a result of industrial bronchitis, and which is related to lifetime dust exposure. Unlike bronchitis induced by cigarette smoke, the predominant effect of industrial bronchitis is on large rather than small airways and the condition is not accompanied by emphysema.
 ...
PMID:Industrial bronchitis. 36 24

134 patients with pollen allergy were studied in a medical practice. The frequency of hay fever was 56%, hay fever with cough 9% and pollen asthma 35%. The following differences were stated: 53.2% of the asthmatics but only 9.3% of patients with hay fever had a history of nonallergic bronchial irritation in the case of acute bronchitis, exercise or irritant gases. Asthmatics showed significantly more frequently positive skin reactions additionally to pollen. The distribution of age of onset of hay fever was similar in both groups. The prevalence of both diseases was the same up to the age of 20 years, after which it remained constant up to 29 for asthmatics and declined in hay fever. In patients with asthma and hay fever the two diseases began within the same year in 48,9%, asthma followed hay fever in 26,7% within 4, in 15,6% within 5--9 and in 8,6% within ten years or later after the begin of hay fever. It could be shown, that the frequency and the distribution of some characteristics of patients with pollen allergy of a medical practice are comparable to epidemiological findings and may be used for long time studies with the purpose to watch the transition of pollinosis to pollen asthma.
 ...
PMID:[Clinical characteristics of patients with pollen allergy (author's transl)]. 52 19

The prevalence of chronic bronchitis was compared in a group of 970 coalminers and in 538 controls by means of a standardized questionnaire and of VC and FEV1 measurements. The coaldust present in the galleries had a low content of free silica and the dust levels were lower than the maximal permissible concentrations with reference to the US standards. The socio-economic characteristics, and mean height values were identical in both groups. The controls were somewhat older than concerning bronchitis symptoms were found in the non-smokers. The non-smokers exposed to coaldust showed higher prevalences of cough and FEV1 abnormalities than their matched controls. The unfavourable effect of exposure to coaldust on the bronchi was masked by cigarette smoking.
 ...
PMID:Airborne coalmine dust and chronic bronchitis. 55 51

Two epidemiological surveys were made by the same research team on the prevalence and the aetiological factors of chronic bronchitis symptoms in coalminers. The first study was made in a coalminers' community of Belgian Limburg, the other one in a representative sample of coalminers regularly at work. In both surveys an excess of dyspnea complaints was observed in comparison to the prevalence of this symptom in controls. These dyspnea complaints often presented themselves as isolated symptoms, without chronic cough or phlegm production. Dyspnea in excess could not be explained by massive fibrosis. The prevalence of the symptom was not linked, neither to the spirometric values, nor to the results of respiratory challenge tests with acetylcholine, tobacco use, or the length of exposure at the coalface. When dyspnea was associated with cough and phlegm production there was on the contrary a statistically significant relation with the spirometric values and the effect of acetylcholine. It seems therefore reasonable to explain at least partially the isolated dyspnea complaints in coalminers by specific mechanisms not related to bronchitis but resulting from the pathological lesions characteristic of simple pneumoconiosis. Complaints of cough and phlegm production appear as a rule later in the coalminer's life. In the groups taken into consideration in the study they were linked with cigarette smoking which appeared as the predominant aetiological factor for these complaints; in a subgroup a synergic action of coaldust, tobacco use and air pollution could be discussed in this respect. Notwithstanding the pathogenic independence of some dyspnea complaints versus cough and expectoration, it is quite clear that when productive bronchitis develops and causes broncho-obstruction, it may aggravate pre-existing dyspneic patterns.
 ...
PMID:Contribution to the natural history of chronic bronchitis in coal-miners. 55 52


1 2 3 4 5 6 7 8 9 10 Next >>