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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The global mortality of bronchial asthma continues to decrease, with a reported 57% decline in age-standardized mortality rates between 1993 and 2006.Asthma may rarely be encountered as a cause of cardiac arrest on arrival in the emergency department these days, especially in high-income countries. Rapid worsening of symptoms and rapid improvement in respiratory status after initiation of treatment have been noted as a hallmark of cardiac arrest due to asthma. A 62-year-old male was admitted to our emergency department after dyspnea and dry coughing attack lasting approximately 15 minutes and resulted in cardiopulmonary arrest. His arterial blood gas analysis showed mixed acidosis with pH 7.00, partial pressure of oxygen (PaO2) 184, partial pressure of carbon dioxide (PaCO2) 90 mmHg, HCO3 - 22.2, lactate 104 mg/dL. He returned to spontaneous circulation after about 30 minutes of cardiopulmonary arrest. The very slight wheeze on expiration was heard in the left lung and his chest x-ray showed increasing permeability of the lung, which suggested air trapping. Based on his history of asthma, the background of medication discontinuation, and physical findings, the diagnosis of cardiac arrest due to an asthma attack was made. Two hours after admission, PaCO2 normalized and his respiratory condition stabilized rapidly. However, epileptic seizures due to hypoxic encephalopathy were prolonged. Although he was then managed in the intensive care unit, he was diagnosed with irreversible brain damage due to hypoxic encephalopathy and shifted to palliative care. Asthmatic cardiac arrest is now rare, but still important. And it may be difficult to identify asthma as a cause of cardiac arrest if the respiratory status improves rapidly. Therefore, keeping in mind the presence of asthma cases of rapid deterioration to cardiopulmonary arrest and case of rapid treatment response may lead to a correct diagnosis.
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PMID:A Case of Fatal Asthma: Rapid Transition to Cardiac Arrest and Rapid Recovery of Respiratory Status. 3315 60

COVID-19 outbreak is one of the most disastrous respiratory diseases (after the 1918 influenza outbreak) spreading in the community. So far, it has killed 7,37,417 number of individuals. High variability in the viral genome and its greater ability to spread in the human community is badly affecting the comorbid individuals. Although infected individuals are mainly possessing respiratory issues, neurological manifestations in these individuals cannot be overlooked. The literature search is based on the recent development in the concerned field. We searched databases like PubMed, Google Scholar, and ScienceDirect using the keywords "COVID-19", "neurological manifestations", "CNS", and "PNS". The major neurological complications observed in these patients are encephalitis, necrotising haemorrhagic encephalopathy, Guillain Barre Syndrome, smell/taste impairment, epileptic seizures, and abnormal states of consciousness. COVID-19 infection is just more than a cough, fever, and respiratory illness; it can cause indirect neurological complications in infected patients. It is therefore advised to treat and have a careful observation of the COVID-19 patients for neurological manifestations.
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PMID:COVID-19 Outbreak: Neurological Manifestations beyond Cough and Fever. 3322 80

Introduction: Acute respiratory syndrome coronavirus-2 (Covid 19) can infect the respiratory system, as well as the central, peripheral nervous system and muscles, leading to neurological symptoms and signs. The most common neurological symptoms are dizziness, headache, impaired consciousness, ataxia, hypogosis, hyposmia, neuralgia and myalgia. The most common neurological diseases are acute cerebrovascular disease, epilepsy, acute hemorrhagic necrotizing encephalopathy, miyelitis and Gullian Barre Syndrome. Methods: In this case report, a patient infected with Covid 19 and diagnosed as neuromyelitis optica (NMO) with anamnesis, clinical and radiological findings is presented. Results: A 50 years old woman presented with weakness of both legs, urine retention, high fever, and cough. Spinal magnetic resonance imaging revealed expensive long-segment and centrally located demyelinating lesion extending from the cervical cord (at the level of C3) to the conus. Thoracic computerized tomography revealed consolidation areas located on the lower segments of bilateral lungs and ground-glass density, air bronchograms, and peribronchial thickening surrounding these areas. Aquaporin-4 immune globulin-G was found to be positive. Conclusion: It was considered appropriate to present this case because of being the first case of parainfectious NMO considered to be induced by SARS-CoV-2. HIGHLIGHTS COVID-19 has neuro-invasion potential independently of the critical disease process Demyelinating lesions such as neuromyelitis optica may develop in the course of disease Parainfectious NMO induced by SARS-CoV-2 may occur as a result of extended immune response.
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PMID:Covid-19 Infection Induced Neuromyelitis Optica - A Case Report. 3328 Apr 77


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