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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been known for many years that bakers, who work in an atmosphere filled with wheat flour and other grain products, often suffer from bronchial asthma and other allergy symptoms. We examined 36 cooks (males: 33, females: 3, average age: 29.1 years) exposed to wheat products while baking bread or making confectionaries in a hotel. Their clinical symptoms were investigated, and peripheral blood eosinophils, serum IgE, wheat flour specific IgE, IgG1, IgG4, and antibodies to alpha-amylase and papain were measured. Clinical symptoms were present in some cases, the most common being rhinitis (13), itching and skin eruptions (8), ocular symptoms, including tearing, itching and conjunctival injection (8), and respiratory symptoms, including cough and sputum production (8). Wheat flour specific RAST was positive in 44.4% of cases. Peripheral eosinophils and wheat flour specific IgG1 levels were increased in those with positive RAST scores. Total IgE level and wheat flour specific IgG4 also seemed to be increased in those with positive RAST scores. Wheat flour specific IgG1 and IgG4 seemed to correlate positively with wheat flour specific IgE. The exposure duration correlated with neither total IgE nor wheat flour specific IgE. In those who were wheat flour RAST positive, wheat flour specific IgG1 levels correlated negatively with exposure duration. In RAST negative cases, however, there was no correlation. Similarly, there seemed to be a tendency for wheat flour specific IgG4 levels and exposure duration to correlate negatively in RAST positive cases. The subjects of this study initially worked in poorly ventilated areas.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:A study of factors contributing to bakers' allergy symptoms. 751 30

The aim of this paper was to study the effect of pets and other domestic animals on bronchial asthma among United Arab Emirates (UAE) schoolchildren aged 6-14 years. A cross-sectional study of 850 schoolchildren living in both urban and rural areas (average age 9.36 +/- 2.11 years, 46.8% boys and 53.2% girls) was conducted using self-administered questionnaires between October 1992 and May 1993. Prevalence rate for asthma, rhinitis, wheeze, cough, and eczema in children from families with and without animals were investigated. A total of 40.7% of families studied were found to keep animals in their homes. Children from families with animals were found to have a significantly higher prevalence rate of respiratory symptoms than those without. The prevalence rate for asthma in children with animals was found to be twice that of children without (RR: 2.03; 95% CI: 1.40-2.95). The risk of having chronic cough (RR: 1.93; 95% CI: 1.21-3.10), breathlessness/chest tightness (RR: 2.53; 95% CI: 1.59-4.02), chronic wheeze (RR: 2.10; 95% CI: 1.20-3.67), allergic rhinitis (RR: 1.53; 95% CI: 1.17-2.00) was significantly higher in children with animals than in children without. Similarly, the risk of having eczema (RR: 2.55; 95%, CI: 1.74-3.75) was significantly higher among children with animals than among those without. Overall, there was a highly statistically significant difference in the prevalence of asthma, wheeze, nocturnal cough, eczema, and rhinitis between children in families with animals and those without (p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Pet ownership in the UAE: its effect on allergy and respiratory symptoms. 755 61

With the aim of determining the prevalence of respiratory symptoms and rhinitis among adolescents in Spain, we sent a brief questionnaire about respiratory symptoms to all school children (9,644) in the sixth, seventh and eight grades in our city. We identified a symptomatic group (SG) consisting of adolescents who reported having had one or more of the following three signs within the past 12 months: a) waking with a feeling of stuffiness; b) experiencing an asthma attack, or c) taking medication for asthma. Returned questionnaires accounted for 74.4% of those distributed. The following symptoms were reported: wheezing by 13.4%, nighttime oppression by 8.4%, stuffiness at night by 7.3%, nighttime coughing by 24.8%, asthma attack by 4.5%, taking asthma medication by 6.1% and seasonal rhinitis by 15.4%. The proportion of symptomatic children was 11.6% (833). All symptoms studied that were not required for inclusion in SG correlated highly with that group (p < 0.0001). Neither age nor sex were related to inclusion.
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PMID:[Respiratory symptoms in a pediatric population]. 758 28

Acid anhydrides are low-molecular-weight chemicals known to cause respiratory irritancy and allergy. Skin allergy has on rare occasions been reported. 2 workers contracted hives and itching on uncovered skin after 2 months exposure to methyltetrahydrophthalic anhydride (MTHPA) and methylhexahydrophthalic anhydride (MHHPA), to which they had airborne exposure. Later, the patients also developed conjunctivitis, rhinitis, sore throat, cough or asthma. In addition to MTHPA, 1 worker was also exposed to unsaturated polyester resin (UP). Both patients' immediate allergy to MTHPA and MHHPA was verified by positive prick tests to MTHPA and MHHPA, conjugated with human serum albumin (HSA), and positive radioallergosorbent tests (RASTs) to these anhydrides. On prick testing, both patients also reacted to a phthalic anhydride (PA)-HSA-conjugate and 1 of the patients to UP-HSA-conjugate. Specific immediate allergy to UP was shown by RAST. RAST inhibition with MTHPA, MHHPA and UP-resin conjugates confirmed IgE-mediated allergy and cross-reactivity between anhydrides. Our patients had developed airborne contact urticaria caused by phthalic anhydrides, in addition to respiratory allergy. Phthalic anhydride contained in the UP resin was possibly responsible for the immediate reaction of the skin.
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PMID:Immunologic contact urticaria due to airborne methylhexahydrophthalic and methyltetrahydrophthalic anhydrides. 760 Jul 75

Nedocromil sodium is a non-steroidal prophylactic agent for the management of asthma. We assessed the effect of inhaled of nedocromil sodium 8 mg/24 h in a double blind, placebo controlled study in 14 patients suffering from seasonal (grass-pollen) asthma. Symptom scores for dyspnoe, cough, rhinitis and airway responsiveness to histamine (PC20H) according to Cockcroft et al were estimated before the grass-pollen season and at the end of 14-day placebo treatment and 21-day nedocromil sodium treatment. During placebo period the significant decrease in PC20H from 1.81 mg/ml to 0.54 mg/ml (p < 0.01) was observed. Nedocromil sodium did not have the effect on nonspecific bronchial responsiveness, PC20 - 0.74 mg/ml (p = 0.25). Subjective global assessment scores were significantly better with nedocromil sodium (31.15 mean 2.23) than with placebo (10.5 mean 0.7) p < 0.05.
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PMID:[Effect of nedocromil sodium on clinical course and histamine airway responsiveness in patients with pollen induced bronchial asthma]. 764 32

Chronic cough is a common symptom in many different disease processes. Because the most effective way to eliminate a chronic cough is to identify and treat the underlying disease, the physician must approach the paediatric patient based on his or her knowledge of the differential diagnosis. The most common causes of cough in children are upper respiratory tract infections, asthma, rhinitis, sinusitis, and gastroesophageal reflux. By using a systematic approach, the cause of a chronic cough can almost always be found, and the cough successfully treated. Asthma is the cause of most undiagnosed chronic coughs but sinusitis, rhinitis, and gastroesophageal reflux must also be considered in difficult patients.
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PMID:Treatment options in the child with a chronic cough. 768 7

The major manifestations of giant cell arteritis have been well described. Pulmonary manifestations, however, are rare. We report the case of a 75 year old woman with temporal arteritis, presenting with atypical manifestations, i.e. nodular pulmonary lesions, dry cough, rhinitis, conjunctivitis, and otitis with hearing loss. We conclude that overlapping features of giant cell arteritis and Wegener's granulomatosis occur in some patients.
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PMID:Unusual manifestations of giant cell arteritis: pulmonary nodules, cough, conjunctivitis and otitis with deafness. 771 13

We carried out a prospective study to analyse if it would be possible to predict the coexistence of acute otitis media on the basis of symptoms and signs of infection. Of the 658 patients admitted to hospital during the period concerned, 197 (29.9%) had otitis media. For each child with otitis, the next patient of the same age was chosen as a control. The risk of having otitis media was increased among patients with cough, rhinitis and earache. All three variables together correctly classified 67% of those not having otitis media and 63% of those with acute otitis, compared with the 50% which would theoretically be achieved by chance alone. Prediction was worst (55%) among patients younger than 2 years of age not having otitis media and best among older patients who had otitis media, i.e. 78%. Prediction on these grounds would have caused significant over-treatment, and one-third of the otitis cases among the youngest group would have been missed. Thus it is important to always examine the ears of a child with an infection in order to reliably exclude the possibility of acute otitis media.
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PMID:Prediction of acute otitis media with symptoms and signs. 773 9

This paper is a report of a cross-sectional epidemiological study that formed part of multicenter European project; the aim was to estimate the prevalence of respiratory symptoms and signs related to asthma over a period of 12 months in the city of Seville. A sample of 4,000 persons of both sexes, aged between 20 and 44 years old, was surveyed first by mail questionnaire and later by telephone interview. We analyzed the response index obtained with the mail survey for the epidemiological study of asthma in the area and for the frequency of respiratory symptoms and their distribution by age and sex. The response index was 53.36% and was similar for men and for women. Forty-nine percent reported at least one respiratory symptom, with nocturnal coughing attacks (27.7%) and wheezing (22.2%) being the most frequent. The frequency of these symptoms was different by sex, however, with the former more often reported by women (p < 0.02) and the latter by men (p < 0.001). We found that 14.9% of the population had rhinitis and that women reported this symptom more often (p < 0.02). Symptoms related to asthma were nocturnal attacks of breathlessness, the use of asthma medication and an asthma attack diagnosed by a physician within the last 12 months. With these criteria the estimated prevalence of asthma was 11.72%, a proportion that held steady for all age groups except the middle-aged and for both sexes.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[An analysis of the prevalence of respiratory symptomatology in the general population]. 854 90

Indoor pollution is a major public-health issue, say representatives from government and the medical profession who participated in a recent workshop in Ottawa. Researchers are certain that indoor pollution causes many of the allergy-related problems and asthma, bronchitis, rhinitis, coughing and others respiratory problems experienced by North Americans. They urge physicians to learn about indoor air quality and to educate patients to improve their environment, particularly with respect to second-hand smoke, dust mites and mould.
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PMID:Indoor air quality a major public-health issue, workshop told. 779 82


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