Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Most children with a cough have recurrent acute viral bronchitis or asthma. For both, the natural history is progressive improvement through childhood. An unrelenting cough with purulent sputum suggests suppurative lung disease and must not be dismissed lightly. In most cases the cause of cough can be determined by careful clinical history, physical examination and chest X-ray. Other laboratory investigations can be useful when underlying asthma is suspected.
 ...
PMID:Children with cough. 673 39

A program of respiratory muscle sparing in 9 patients with late stage Duchenne muscular dystrophy is presented. Results indicate that regular efficient night-time support by body respirator provides a constant significant improvement in daytime gas exchange for periods averaging up to 2 years following the occurrence of moderately severe respiratory failure. Until now, the longest survival is more than 4 years at the age of 28. the average PaCO2 and PaO2 before night ventilation were 60.8mmHg and 59.3mmHg, respectively. The levels after the program was begun were 45.5 (PaCO2) and 74.6 (PaO2). These arterial blood gas levels are acceptable for good cardiopulmonary homeostasis. There have been no deaths or episodes of cardiac failure since the program began. The ease of integrating the program into the patient's lifestyle and home are important advantages. Cost of equipment is discussed. The view that these patients are terminal must be qualified. A case is also made for early aggressive conservative measures including body respirators, postural drainage, chest physiotherapy with abdominal assisted coughing, intratracheal suctioning and bronchoscopy to combat respiratory infection, and decreasing the need of tracheostomy and volume ventilators which can be so disabling to the chronic restrictive lung disease (CRLD) patient. Research and development into better design of body respirators is vitally needed. Acute care hospitals must prepare themselves for such patients who now attain more independent living and longer lifespan. For this reason there is a growing need for these facilities to acquire tank ventilators for handling such patients who may need hospitalization for acute medical complications.
 ...
PMID:Night ventilation by body respirators for patients in chronic respiratory failure due to late stage Duchenne muscular dystrophy. 678 53

A patient employed in a plant where blue cheese was manufactured developed hypersensitivity pneumonitis to Pencillium roqueforti. Symptoms of cough, dyspnea, and malaise, and findings of bibasilar crackles, reduced lung volumes, hypoxemia, and bilateral infiltrates on chest roentgenogram, resolved after she left the workplace. Bronchoalveolar lavage revealed a high percentage of lymphocytes. Antibody to P. roqueforti was demonstrated in serum and lavage fluid. To our knowledge this case represents a new occurrence of hypersensitivity lung disease in the cheese manufacturing industry in the United States.
 ...
PMID:Cheese worker's hypersensitivity pneumonitis. 683 56

Occupational immunologic lung disease can be identified both in the individual patient under laboratory conditions and in a population of workers in industry. Occupational airways disorder is the most common occupational immunologic pulmonary process and is a disease of the airways caused by the inhalation of a substance or material that the worker manufactures or uses directly or that is incidentally present at the worksite. There are several occupational airways disorders, including industrial bronchitis, occupational asthma, and reactive airways disease syndrome, the latter two of which will be discussed more thoroughly. Occupational asthma can be appropriately identified when the following are present (1) typical symptoms, i.e., wheeze, cough, shortness of breath, and/or chest tightness; (2) specific identification of the offending agent; (3) documentation that the agent can cause asthma; (4) wheezes on physical examination; (5) pulmonary function changes; (6) immunologic abnormalities; (7) airway hyperreactivity; and (8) positive bronchial challenge with specific material. The diagnosis of occupational airways disorder requires a comprehensive approach, including clinical history, physiologic measurements, immunologic testing, and identification of airway hyperreactivity. By this approach both individual subjects and working populations can be studied.
 ...
PMID:The evaluation of occupational airways disease in the laboratory and workplace. 708 3

All the Tahitian school children from 3rd to final grade were questioned by an auto-questionnaire in May 1979. 93% replied to the questions asked (3,870). The prevalence of upper respiratory infections was increased as well as broncho-pulmonary symptoms (cough or other lung disease) during the year under study when compared to a control group in Metropolitan France. This prevalence was significantly increased both in boys and girls who smoked. The incidence of frequent or chronic cough was most increased in the older pupils, boarders, those followed a technical curriculum and belonging to the lower socio-professional categories. Asthma was very frequent at 11.5%, had an equal sex incidence and was not linked to any identifiable factor--the same enquiry was done in the Bas-Rhin department in France 3 years before; Tahitian school children, in general, have double the incidence of respiratory disease that is found in the Bas-Rhin.
 ...
PMID:[Prevalence and aetiology of respiratory symptoms and affections in adolescent school children in French Polynesia (author's transl)]. 710 Jun 15

Breathing air from a humidifier or an air conditioning unit contaminated by various microorganisms can cause an acute lung disease involving fever, cough and dyspnea, termed "humidifier fever". This type of hypersensitivity pneumonitis was first described in 1959 by PESTALOZZI in the Swiss literature and subsequently by BANASZAK et al. in the Anglo-American. Here a chronic form of this disease which led to pulmonary fibrosis is described: A 37-year-old woman who works in a cheese shop presented with dyspnea which had been progressive over two years, weight loss, a diffuse reticular pattern radiographically and a severe restrictive defect in lung function tests. Open lung biopsy revealed chronic interstitial and alveolar inflammation with non-caseating granulomas and fibrotic changes. Circulating immune complexes and precipitins against the contaminated humidifier water and cheese mites were found, but no antibodies suggesting legionnaires' disease. Two out of five otherwise healthy employees of this cheese shop, where a new humidifying system had been installed 7 years earlier, also had precipitins against the contaminated water from the humidifier and the cheese mites. Despite ending of exposure and longterm steroid and immunosuppressive therapy, the signs and symptoms of pulmonary fibrosis persisted. Contrary to the acute disease, this chronic form is termed "humidifier lung". The importance is stressed of investigating the possibility of exposure to contaminated humidifiers or air conditioning units in all cases of newly detected pulmonary fibrosis.
 ...
PMID:[Humidifier lung]. 722 22

Seven patients with severe, unexplained chronic bronchial suppuration and inflammatory bowel disease are reported. In three, rapidly progressive bronchiectasis developed within one year of procto-colectomy, in two it developed in association with an exacerbation of colitis and in the other two a milder, limited colitis post-dated the start of the lung disease. The high incidence of arthropathy and skin rashes suggests a systemic disease, and personal and family histories of auto-immune conditions were common. Antinuclear antibodies were detected in six and smooth muscle antibodies in five of the seven patients and there was no evidence of liver disease. Evidence of circulating immune complexes was found in two patients. In the four patients who received corticosteroid therapy there was an impressive improvement in cough, sputum volume and dyspnoea, especially when taking high doses. Because of the time relationships of the bowel and lung symptoms, we suggest that these disorders may be related.
 ...
PMID:Chronic bronchial suppuration and inflammatory bowel disease. 726 68

Acute exposure to selenium hydrochloride resulted in severe dyspnea and a pneumomediastinum in a young healthy man. Pulmonary function tests revealed restrictive and obstructive airways disease. Although the patient's pulmonary function slowly improved, subsequent studies revealed persistent impairment. Therefore, exposure to selenium gas may result acutely in severe coughing and wheezing and may lead to irreversible obstructive lung disease.
 ...
PMID:Acute hydrogen selenide inhalation. 735 82

Five infants who had been patients in the same Neonatal Intensive Care Unit (NICU) were readmitted with respiratory illness. The illness was characterized by cough, congestion, apnea, and infiltration of the lungs revealed by radiographic examination. Only one infant was febrile. All five patients recovered; however, one infant required prolonged intubation and mechanically assisted ventilation. Investigation revealed that the illness was associated with prematurity and contact with ill family members. Illness was not associated with exposure to ill personnel in the NICU, low birth weight, or previous lung disease. This outbreak demonstrates the dangers involved in sending premature infants home when respiratory illness is prevalent in the family.
 ...
PMID:Family-acquired respiratory disease in high-risk infants. 736 36

The proposal that some naturally occurring prostaglandins (PGs) or their by-products may be implicated in the pathogenesis of the asthmatic bronchospasm has been suggested. Other PGs may be potentially useful in the treatment of this lung disease. The present investigation compared the bronchodilator effects of PGE1 and PGE2 in pharmacologically constricted experimental animals. In pentobarbital-anesthetized, spontaneously breathing dogs, aerosols of PGE1 and PGE2, 0.0002 to 0.2%, effectively inhibited the increases in pulmonary resistance (RL) and decreases in dynamic lung compliance (CDYN) produced by PGF2 alpha (3.0 micrograms/kg i.v.). PGE2 was found to be more effective than PGE1 in preventing RL responses to PGF2 alpha; however, both bronchodilators were equally effective vs. CDYN changes. These agents inhibited central airway constriction more than peripheral. Transient decreases in systemic arterial pressure and increases in heart rate occurred especially at the higher concentrations. In a group of trained conscious dogs, effective concentrations did not evoke adverse subjective discomfort or irritation. Higher concentrations, i.e., 1.0%, did produce coughing, breathholding, restlessness and altered patterns of breathing. In normal or sensitized guinea pigs, PGE aerosols were effective in reducing the bronchopulmonary provocation produced by histamine or specific antigen. These in vivo results suggest that aerosols of the classical PGEs are effective bronchospasmolytics in laboratory animals and that irritation may be related to concentration.
 ...
PMID:Inhibition of bronchoconstriction by aerosols of prostaglandins E1 and E2. 739 72


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>