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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A community study of respiratory disease on Karkar Island sampled 1734 people. Both sexes showed abnormalities, especially those over 35 years. 33% had a positive loose cough, 29% had adventitious sounds, and 11% had persistent cough. Smoking was universal by age 30. A local cigar made from the same type of tobacco (Brus) as commercial cigarettes (Nicotiana tobaccum) was the favorite smoke. Store bought cigarettes were used by 8% men, .8% women. 1.8% men and 12% women who smoked local tobacco inhaled, compared to 56% men who smoked commercial tobacco. Inhalers showed a higher frequency of symptoms than noninhalers. Nonsmokers had consistently higher values for lung function tests. However, differences in lung function were significant only in the FEV percentage in women. Wider use of commercial tobacco will likely increase inhalation leading to an increase in lung disease.
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PMID:Smoking habits and their relationship to chronic lung disease in a tropical environment in Papua New Guinea. 444 55

Acute exposures to hemp dust, in healthy subjects as well as hemp workers with byssinosis, resulted in two different responses. Men with symptoms (chest tightness, coughing, and wheezing) after exposure showed decreases of forced expiratory volumes (FEV(1.0)), flow rates on maximum expiratory flow-volume (MEFV) curves, and of vital capacity (VC), while airway conductance (Gaw: TGV ratio) did not decrease significantly ("flow rate response"). Men without symptoms after exposure showed no changes of VC, FEV(1.0), and MEFV curves, but had a significantly decreased airway conductance ("conductance response"). The flow rate response is attributed to a pharmacological bronchoconstrictor effect of hemp dust on small airways, the conductance response to a mechanical or reflex effect of hemp dust on large airways. Both responses were abolished by a bronchodilator drug. The type of response reflects a difference between individuals and is not related to age, smoking habits, or prior exposure history. Men with normal control function data had either a flow rate or a conductance response. All men with abnormal control data had a flow rate response.Long-term hemp dust exposure causes irreversible obstructive lung disease, in particular among men who respond to acute dust exposure with symptoms and flow rate decreases. The detection of this response, with FEV(1.0) measurements and MEFV curves, is essential in the study of byssinosis. Decreases of airway conductance after dust exposure have no consistent relation to the development of clinical symptoms. The relative value of measurements of maximum expiratory flow rates and of airway conductance in other lung diseases needs to be reassessed.
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PMID:Respiratory mechanics and dust exposure in byssinosis. 540 99

A man with alleged Crohn's disease of the terminal ileum was started on sulfasalazine. Five weeks later he developed progressive cough, shortness of breath, and fever associated with peripheral eosinophilia and bilateral pulmonary infiltrates. After withdrawal of sulfasalazine all abnormalities returned to normal. This case supports the conviction that there is an entity of sulfasalazine-induced lung disease.
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PMID:Sulfasalazine pneumonitis. 613 83

Both upper and lower respiratory tracts can be affected by food allergy. Manifestations in either may be exclusively due to food allergy (common in infants) or may result from the combined effects of food allergy plus another defect such as gastroesophageal reflux, a congenital defect of the heart or tracheo-bronchial tree, an immunodeficiency syndrome such as isolated IgA or IgG4 deficiency, or a concomitant inhalant allergy. Chronic rhinitis is the most common respiratory tract manifestation of food allergy. When it occurs in conjunction with lung disease, it may be a helpful indicator of activity of the allergic lung disease and of the patient's compliance in following a specific diet. Recurrent serous otitis media may be solely or partially due to food allergy. Large tonsillar and adenoid tissues, sometimes with upper airway obstruction, may be caused, or aggravated by, food allergies. Lower respiratory tract disease manifested by chronic coughing, wheezing, pulmonary infiltrates, or alveolar bleeding may also occur. Lower respiratory tract involvement is generally associated with a greater delay in onset of symptoms and with a larger quantity of allergen ingestion than chronic rhinitis. Food allergy should be considered when there is a history of prior intolerance to a food in childhood or of symptoms beginning soon after a particular food was introduced into the diet. It is an important consideration in patients who have chronic respiratory tract disease which does not respond adequately to the usual therapeutic measures and is otherwise unexplained.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Respiratory diseases and food allergy. 623 77

An analysis is made of the contribution of clinical examination to the diagnosis of primary bronchopulmonary cancer in a lot of 355 patients. As it is known bronchopulmonary cancer does not have a characteristic and patognomonic clinical symptomatology. In two thirds of the patients (236/66.4%) the disease' onset was marked by respiratory symptoms. In half of these patients (120/33.8% of the total number of cases) the respiratory syndromes for which the patient had requested medical help could have suggested the diagnosis, and were marked by a pseudo-pneumonia, or pneumopathy with long evolution, intensified coughing in a patient who had been coughing for a long time, or an onset marked by hemopthysis. In the other half of the patients in this group the onset symptoms had nothing characteristic. The onset marked by metastases was noted 69 of the patients (19.4%), and para-neoplastic syndromes were noted in 10 (2.8%). These certainly suggested the presence of pulmonary cancer. It appears that in over half of the patients 9195, or 54.1%) the clinical examination could suggest the existence of bronchopulmonary cancer, and this percentage increases if patients are included in those whose respiratory symptoms are not characteristic but in those which physical examination will evidence suggestive changes. Only in a very small number of patients (12, or 3.3%) the clinical examination did not provide any diagnostic element. These were the asymptomatic cases, accidentally identified in the course of a radiological examination. It should be stressed that the clinical suspicion of pulmonary cancer should always be confirmed by paraclinical investigations.
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PMID:[The contribution of the clinical examination to the diagnosis of bronchopulmonary cancer]. 629 7

A case is presented, of a patient with acute fungal pneumopathy. The evolution of the disease in this 63 years male was short and rapid, characterized by fever, dyspnea, thoracic pain, muco-purulent expectoration and intense coughing. In spite of the complex treatment applied the patient died with acute cardio-respiratory failure. The radiological examination revealed micro-nodular and nodular opacities extending predominantly in the left lung. Laboratory investigations included a microbiologic study for the Koch bacillus, which was negative. The post-mortem examination revealed multiple focuses with suppurative aspects on a diffuse background of hepatization. The microscopic examination evidenced the presence in the respective focuses of abundant colonies of Candida and Aspergillus, and a hematogenic invasion with Candida and allowed to determine a diagnosis of acute pneumopathy of fungal origin as a result of a double infection with Candida and Aspergillus strains.
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PMID:[Acute fungal pneumopathy caused by Candida and Aspergillus (case report)]. 629 80

Open heart surgery is associated with postoperative sternal pain, which is exacerbated by cough, deep breathing and movement, thus limiting the physical activity of the patient. Transcutaneous electrical nerve stimulation (TENS) was administered to 40 patients suffering from persistent chest pain immediately following open heart surgery, and to ten other patients complaining of pain between three and eight weeks after operation. The efficacy of TENS was assessed by the subjective recordings, analgesic drug requirement, capability to carry out deep inspirations with an "Incentive Deep Breathing Exerciser" apparatus, and repeated chest X-ray examinations. We conclude that TENS is a useful method of pain control and should be used more frequently in patients after open heart surgery, especially in the older patient and in patients with chronic lung disease.
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PMID:Transcutaneous electrical nerve stimulation (TENS) after open heart surgery. 633 86

PH is an uncommon manifestation of SLE. The symptoms of PH develop within a few years after the onset of the multisystem disease. The most common presenting complaints of SLE patients with PH are dyspnea on exertion, chest pain, nonproductive cough, edema, and fatigue or weakness. The important physical findings are a loud second pulmonic heart sound and a right ventricular lift. The chest roentgenogram shows a cardiomegaly, a prominent pulmonary segment, and usually clear lung fields. Pulmonary function tests may show evidence of restrictive lung disease; however, the physiologic abnormalities are mild and out of proportion to the severity of the PH. The diagnosis of PH is established by cardiac catheterization showing elevated pulmonary artery pressure, normal capillary wedge pressure, and no evidence of intracardiac or extracardiac shunts. Pathologic examination of the lung demonstrates angiomatoid lesions involving muscular pulmonary arteries. There is a thickening of the media and subintima of the arterioles. Immunoglobulin and complement deposits are found in the walls of pulmonary arteries. Immunoglobulin eluted from the lung contains rheumatoid factor and antinuclear antibody including antibody to DNA activity. DNA antigen is also present in walls of blood vessels. These results suggest an immune complex deposition process as a mechanism in the pathogenesis of PH in SLE. The clinical course of PH in SLE is variable. Symptoms may be mild and the disease follows a stable and protracted course for several years. It can, however, develop a progressive course ending in death in a few years. The clinical response of SLE patients with PH to treatment with high doses of systemic corticosteroids is not consistent or predictable.
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PMID:Immunopathologic and clinical studies in pulmonary hypertension associated with systemic lupus erythematosus. 637

Twelve cases of interstitial pneumonitis were seen in 50 patients (24%) treated with cyclophosphamide, methotrexate, and etoposide (VP-16-213) for small cell anaplastic lung cancer. The clinical course and pathologic characteristics were consistent with drug-induced pneumonitis in all 12 cases. One additional patient had concurrent histologic evidence of interstitial pneumonitis, pneumocystis infection, and perivascular metastases. Patients presented with severe dyspnea, hypoxemia, cough, fever, and bilateral interstitial infiltrates on chest films. The onset was rapid and unpredictable, following as little as one month or as much as five months of therapy. Nine patients recovered but there were three deaths in the acute period directly attributable to the drug-induced pneumonitis. Although the use of twice weekly oral methotrexate may have been a causative factor, a previously unsuspected drug interaction with etoposide may be the etiologic factor resulting in this unusually high incidence of pulmonary toxicity. The difficulty in establishing a diagnosis of interstitial pneumonitis in this group of patients with chronic lung disease and lung cancer is well known. The extent of morbidity and mortality seen in this study and the commercial availability of etoposide make earlier clinical recognition of this complication imperative.
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PMID:Chemotherapy-induced interstitial pneumonitis during treatment of small cell anaplastic lung cancer. 672 94

In order to determine the present clinical spectrum of broncholithiasis and the impact that chest computed tomographic (CT) scans, laminograms , and fiberoptic bronchoscopy ( FOB ) have had on the diagnosis and treatment of this entity, we reviewed our experience between 1970 and 1982. Nineteen patients were identified with this diagnosis. Cough, hemoptysis, and obstructive pneumonia were the most common presentations. Lithoptysis occurred in only 3 patients. The chest radiographic findings were nonspecific, but in 8 of the 19 patients, laminograms or chest CT scans helped establish the diagnosis; FOB was performed on 18 patients and was abnormal in each case, with 8 intrabronchial calcifications identified. However, FOB has limited therapeutic indications in this disorder. Depending on the patient's clinical status and underlying lung disease, observation, bronchoscopic removal of the stone, or surgical resection may be indicated.
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PMID:Advances in the diagnosis and treatment of broncholithiasis. 673 45


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