Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case of aspiration admitted to our rehabilitation unit in a patient with dysphagia due to diffuse idiopathic skeletal hyperostosis or Forestier's disease of the cervical spine, in whom an episode of pneumonia had occurred. Clinical and instrumental findings, including radiography of the spine, (CT Scan) and videofluoroscopy, confirmed the diagnosis. The dysphagia was hypothesized to be due to mechanical compression and inflammatory changes, accompanied by fibrosis in the esophagus wall. The aspiration pneumonia probably had multifactorial etiology: dysphagia, abnormal cough reflex, colonization of the oropharynx by virulent bacteria, etc. No aspiration pneumonia occurred after medical treatment and rehabilitation had been started. We review the medical literature on this unusual cause of aspiration pneumonia.
 ...
PMID:An unusual cause of aspiration pneumonia. 1660 41

Background. The purpose of the study is to present preliminary results of treatment of dysphagia in patients with Forestier's disease. Material and methods.3 patients with Forestier's disease were treated surgically due to increasing difficulties swallowing. The average age was 57 yrs. All three patients presented with cough and hoarseness. Results. Surgical intervention relieved the patients from dysphagia. All three regained the ability to swallow and obtained relief from hoarseness and cough within a few months after surgery. Conclusion. We observed that dysphagia due to skeletal hyperostosis may be the main symptom in Forestier's disease. Pharmacological treatment in the initial period of the disease decreases edema of the mucous membrane in the esophagus.
 ...
PMID:Dysphagia in Forestier's disease. 1767 14

We report the case of a 75-year-old man who presented at the emergency department complaining of difficult breathing, especially when in supine position. He had cough, dysphonia, and dysphagia for fluids in the last few months. After ruling out other causes of dyspnea, a lateral cervical radiograph was performed that showed large osteophytes compressing the airway, which was confirmed by cervical computed tomography. Marked improvement of symptoms was observed after resection of the osteophytes compressing the airway. Diffuse idiopathic skeletal hyperostosis, or Forestier disease, is an ossifying disease of ligaments and tendons and affects mainly elderly men. Anterior longitudinal ligament ossification is characteristic. Although it is asymptomatic in some occasions, the disease may produce dysphagia, dysphonia, and exceptionally breathing difficulties due to airway compromise. In these cases, early surgery is recommended to alleviate airway obstruction.
 ...
PMID:Forestier disease: an unusual cause of upper airway obstruction. 1909 Dec 95

Osteophytes of the cervical spine are usually seen in elderly adults. When prominent, they have been blamed for dysphagia, cough, dysphonia and dyspnoea. This paper reports on an obstructive sleep apnoea (OSA) patient with cervical spinal osteophytes, one cause of airway obstruction. A 75-year-old male complained of pronounced snoring. The diagnosis was mild OSA, apnoea hypopnoea index was 9.4. Patient reported no restrictions in neck movements, experiences of neck pain or neck trauma. Previously, patient underwent a tonsillectomy due to discomfort in the pharyngeal region. A lateral cephalometric image was taken to observe airway before oral appliance therapy. The image revealed the presence of large osteophytes or sclerotic enthesopathy, lying on anterior surfaces from the fourth to seventh cervical vertebrae. A computed tomography (CT) image revealed the relationship of airway position to the spine. In the reconstructed three-dimensional (3D) image, the airway appeared displaced to the right of the craniomandiblar bone, with the hyoid bone similarly displaced in a manner to that of the airway. The spine also appeared displaced to the left side ofcraniomandiblar bone. Additionally, the 3D image revealed calcification of the stylohyoideum ligament and ligamentum nuchae. This present case highlights the necessity of CT examination for OSA patients. There were several ligament calcifications in the head and neck region. Cervical spine osteophytes, as a component of Forestier's or cervical spine disease, have been associated with dysphagia and dysphonia. It was reported that bilateral vocal cord paralysis was caused by osteophytes compressing the post-cricoid area of larynx.
 ...
PMID:A case of obstructive sleep apnoea with anterior cervical osteophytes. 1970 80

Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory degenerative disease that affects multiple spine levels and, in combination with osteoporosis, makes vertebrae more prone to fractures, especially in elderly people. We describe a rare case of thoracic fracture in an ankylosed spine in which hemoptysis was the only clinical sign. The patient (age in the early 80s) presented with chest pain and a cough associated with hemoptysis. The patient had no complaints of back pain and no neurological symptoms. Computed tomography (CT) angiography of the chest revealed changes consistent with DISH, with fractures at the T8 and T9 vertebra as well as lung hemorrhage or contusion in the right lung base. CT and magnetic resonance imaging of the thoracic spine showed similar findings, with a recent T8-T9 fracture and DISH changes. The patient underwent percutaneous pedicle screw fixation from T7 to T11 and remained neurologically intact with an uneventful postoperative course.
...
PMID:Hemoptysis as the Presenting Clinical Sign of a T8-T9 Spine Fracture with Diffuse Idiopathic Skeletal Hyperostosis Changes. 2741 84