Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The seroprevalence of antibodies to HIV-1, HTLV-I, and HCV was evaluated in three populations from northern rural Haiti: 1,727 patients attending the hospital for symptoms suggestive of HIV disease, 228 consecutive surgical patients, and 500 pregnant women were tested. HIV-1 seroprevalence was 6.1 and 4.0% in the last two groups, respectively, and 39.3% in the symptomatic population. Associated symptoms of wasting, cough, and diarrhea and a clinical diagnosis of AIDS were significantly predictive of HIV-1 seropositivity. Antibody to HTLV-I seroprevalence ranged from 2.2-5.3% in pregnant women, surgical patients, and HIV-seronegative symptomatic patients and was similar among the three groups when stratified by age. In contrast, HIV-1 seropositivity and HTLV-I seropositivity were significantly associated. The prevalence of confirmed antibody to HCV was low and not associated with either HIV-1 or HTLV-I seropositivity.
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PMID:Antibody to HIV-1, HTLV-I, and HCV in three populations of rural Haitians. 133 30

A 46-year-old man was admitted to Oita Medical College Hospital on October 16, 1987, because of cough and sputum. Chest X-ray and chest CT films showed diffuse reticulonodular shadow. The specimens obtained by transbronchial lung biopsy revealed cysts of pneumocystis carinii. Abnormal lymphocytes with lobulated nuclei were found 2-7% of peripheral leucocytes. The anti HTLV-I antibody was positive. According to these data, we diagnosed the patient as smoldering adult T cell leukemia with pneumocystis carinii pneumonia. The abnormal shadow on chest X-ray disappeared after SMX-TMP and pentamidine treatment. After about 1 year, he was again admitted for high fever. Chest X-ray showed infiltration with cavity in right upper lobe. Streptococcus pneumoniae was isolated from the sputum. The infiltration shadow on chest X-ray disappeared after antibiotics treatment. However, multiple nodular shadow appeared on the chest X-ray and ATL cell infiltration was found in the specimens of transbronchial lung biopsy. ATL cells in peripheral blood also increased and serum LDH and Calcium levels were markedly high. According to these data, we diagnosed the patient as having a ATL crisis. Although chemotherapy for ATL was started, the ATL, cell infiltration shadow on the chest X-ray enlarged, and bilateral diffuse patchy shadows was appeared on the chest X-ray. He died of respiratory failure on April 26, 1989. Cytomegalovirus pneumonia and ATL cell infiltration were revealed by necropsy.
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PMID:[A case of smoldering adult T-cell leukemia complicated by various pulmonary infections]. 166 67

A 16-year-old male was admitted with a history of cervical lymph node swelling, high fever, cough and hemosputum. On admission, bilateral cervical lymph nodes swelling and fine crackles in the right lower lung field were noted. A chest X-ray film showed an infiltrative shadow in the right lower lung field and right hilar enlargement. Cervical lymph node biopsy specimens revealed wide areas of necrosis with nuclear debris. Transbronchial lung biopsy showed infiltration of lymphocytes in the interstitium and bronchoalveolar lavage fluid showed increased T-lymphocytes and a decreased T4/T8 ratio. The patient was diagnosed to have subacute necrotizing lymphadenitis with T-lymphocyte alveolitis. Additionally, antinuclear antibodies were positive, and anti HTLV-I antibody was false positive. These findings suggested an immunological abnormality in this case. His cervical lymph node swelling and infiltrative shadow on chest X-ray film improved with steroid therapy. Our case may be the first case of subacute necrotizing lymphadenitis with T-lymphocyte alveolitis.
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PMID:[A case of subacute necrotizing lymphadenitis with localized interstitial pneumonia]. 226 30

A 53-year-old woman born in Kamo village of Shizuoka prefecture was admitted to Juntendo Izunagaoka hospital complaining cough and appetite loss. On physical examinations, general lymphadenopathy and hepatosplenomegaly were recognized. And also dry rales and wet rales were heard in the bilateral lungs. On hematological examinations, leukocytes has counted 74,900/microliters, of which 61% atypical lymphocytes, and there were HTLV-I infection and positive anti-ATLA antibody. By the above results, she was diagnosed as adult T cell leukemia (ATL). T cell subset analysis was (CD4-, CD8-, CD3-), which is rare in ATL. Three months after the admission, she was died of disturbances of respiratory function in spite of VEPA therapy. Surface marker changed from CD3- to CD3+ in the course. To illuminate this mechanism will be a key step for the future study.
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PMID:[Adult T cell leukemia with CD4- and CD8-]. 252 5

A 37-year-old woman was admitted to our hospital with the complaints of cough, lymph node swelling. Chest X-ray film showed diffuse small nodular shadows in the bilateral lower lung fields. Bronchoalveolar lavage fluid revealed an increased proportion of lymphocytes (71%) with low OKT4/T8 ratio (0.26). Lung tissue biopsied by bronchofiberscopy showed the existence of interstitial pneumonia. Precipitating antibodies in this patient's serum against various antigens including Trichosporon cutaneum were positive. After admission, all symptoms resolved gradually without specific therapy. But, as soon as the patient was discharged and returned to her home, all symptoms including fever, cough, dyspnea and lymphadenopathy recurred rapidly. The diagnosis of hypersensitivity pneumonitis was made on the basis of these laboratory findings and clinical course. The patient died from respiratory failure after detection of anti-HTLV-I antibody, and autopsy revealed massive ATL cell infiltration of lung tissue, and immunoenzymatic analysis showed a high OKT4/T8 ratio (3.5). Chronic HTLV-1 infection since infancy was suspected in this case, to have modified the immune regulation of the lung, and to have led to the onset of hypersensitivity pneumonitis and the active immune response in the lungs, finally followed by the acute exacerbation of ATL.
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PMID:[A case of smoldering ATL associated with hypersensitivity pneumonitis]. 833 46

A 54-year-old woman was admitted to Juntendo Izunagaoka Hospital on Aug. 29, 1998, after experiencing cough and fever for 19 days. Chest X-ray films disclosed infiltrates in the left lung field. The abnormal lung shadows progressed despite antibiotic therapy, and enlargement of superficial lymph nodes and hepatosplenomegaly developed. Peripheral blood examination disclosed cleaved lymphoid cells without granular cytoplasm. Anti-HTLV-I antibody titer was x320, and the monoclonal integration of HTLV-I provirus was confirmed by Southern blot analysis. Surface marker analysis of lymph node cells was positive for CD2, CD3, CD4, CD5, CD56, and HLA-DR. The above results yielded a diagnosis of adult T-cell leukemia. LSG-4 therapy alleviated the lung infiltrations and dyspnea. This case was considered unusual because of the expression of the natural killer cell marker CD56 on leukemic cells and the presentation of abnormal lung shadows possibly due to leukemic cell infiltration.
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PMID:[CD56-positive adult T-cell leukemia manifested by abnormal lung shadows]. 1069 96

A 58-year-old woman was admitted to our hospital complaining of fever, dry cough, and exertional dyspnea. Chest radiographs showed diffuse interstitial infiltrates in both lungs, and blood gas analysis showed moderate hypoxemia. The levels of serum KL-6 and beta-D-glucan were markedly elevated. Bronchoscopy was performed and Pneumocystis carinii was found in the BALF and transbronchial lung biopsy specimens. A positive reaction for the HTLV-I antibody was obtained, and HTLV-I proviral DNA was demonstrated. A conclusive diagnosis of Pneumocystis carinii pneumonia in a smoldering ATL patient was made on these grounds. Without specific treatment for Pneumocystis carinii pneumonia, the symptoms and abnormal chest radiographic findings disappeared. This case suggests that the fluctuation in cell-mediated immunity associated with HTLV-I carriers may allow recovery from Pneumocystis carinii pneumonia even without antipneumocystis therapy.
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PMID:[Spontaneous resolution of Pneumocystis carinii pneumonia]. 1197 68