Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intranasal administration of a 4% solution of cromolyn sodium for the treatment of ragweed hay fever was tested in an 8-week double-blind matched-pair study involving 66 patients. Patients on active drug received 5.2 mg into each nostril 6 times daily; control patients received a placebo spray. The treated group showed a significant reduction in mouth breathing (p less than 0.001), stuffy nose (p less than 0.002), runny nose (p less than 0.003), and postnasal drip (p less than 0.035). Patients receiving the active drug also reported fewer sneezing episodes (p less than 0.003) and nose blowing episodes (p less than 0.015). One patient using cromolyn solution developed nasal ulceration, tongue swelling, coughing, and wheezing. Other side effects were minimal and occurred with equal frequency in both groups. In the treated group relief of symptoms was most marked in patients with high preseasonal levels of IgE ragweed antibody. Intranasal 4% cromolyn solution appears to be an effective drug for the treatment of ragweed hay fever; measurement of the preseasonal level of IgE ragweed antibody is a useful screening test to identify patients most likely to achieve a maximal beneficial response to treatment.
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PMID:Preseasonal IgE ragweed antibody level as a predictor of response to therapy of ragweed hay fever with intranasal cromolyn sodium solution. 40

134 patients with pollen allergy were studied in a medical practice. The frequency of hay fever was 56%, hay fever with cough 9% and pollen asthma 35%. The following differences were stated: 53.2% of the asthmatics but only 9.3% of patients with hay fever had a history of nonallergic bronchial irritation in the case of acute bronchitis, exercise or irritant gases. Asthmatics showed significantly more frequently positive skin reactions additionally to pollen. The distribution of age of onset of hay fever was similar in both groups. The prevalence of both diseases was the same up to the age of 20 years, after which it remained constant up to 29 for asthmatics and declined in hay fever. In patients with asthma and hay fever the two diseases began within the same year in 48,9%, asthma followed hay fever in 26,7% within 4, in 15,6% within 5--9 and in 8,6% within ten years or later after the begin of hay fever. It could be shown, that the frequency and the distribution of some characteristics of patients with pollen allergy of a medical practice are comparable to epidemiological findings and may be used for long time studies with the purpose to watch the transition of pollinosis to pollen asthma.
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PMID:[Clinical characteristics of patients with pollen allergy (author's transl)]. 52 19

Respiratory symptoms and personal history of allergy were examined in 1659 children, including the entire elementary school population of four villages of the Belgian Ardennes. Levels of atmospheric pollution were monitored during the survey and proved to be very low. It is suggested that socio-economic factors produce a small increase in respiratory symptoms, particularly in cough symptoms. A personal history of eczema and of hay fever was highly associated with dyspnea and wheezing.
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PMID:The relationship between host factors of allergic nature and respiratory symptoms. 60 23

A limited investigation of respiratory and other symptom prevalence, plus before and after shift ventilatory capacity was conducted among a group of 17 meat wrappers exposed to pyrolysis products of polyvinyl chloride and a group of 21 control subjects. Exposed meat wrappers showed a higher prevalence of cough, phlegm, hay fever, and asthma than did the control group. The exposed group also demonstrated relative decreases in forced expiratory volume, one second (FEV1.0) and forced expiratory flow 50% (FEF50) after one shift of work; whereas, the controls showed an opposite tendency. These findings suggest that meat wrappers exposed to pyrolysis products of polyvinyl chloride might be adversely affected. The results, while suggestive, are not totally conclusive owing to the fact that there was not ideal matching of the exposed and control groups in regard to age, height, race, sex, and smoking status.
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PMID:Polyvinyl chloride pyrolysis products. A potential cause for respiratory impairment. 113 32

We have undertaken a double blind placebo controlled study of the effect of nasal beclomethasone on the tendency to wheeze in 20 unselected hay fever sufferers, half with a history of previous seasonal wheezing. We found no difference between either bronchial hyperresponsiveness, as measured by methacholine challenge, home-monitored PEFR, nor recorded wheeze nor cough between treated and placebo groups although the numbers were small. All were allowed the antihistamine cetirizine hydrochloride 10 mg daily. Eighteen out of the 19 patients had either bronchial hyperresponsiveness (PD20 methacholine < 8 mumol or a > 2 doubling dose change in their PD20 during the pollen season). We have shown a significant positive correlation between a hay fever score (HFS) (created by taking the sum of the home scored; nasal discharge, nasal blockage, eye irritation, sneeze and antihistamine use) and peak seasonal specific IgE to mixed grass pollen (Spearman correlation coefficient 0.5 P < 0.02). There was also a positive correlation between the rise in specific IgE from pre to peak season and the HFS, correlation coefficient 0.6 P = 0.03).
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PMID:Investigation of the tendency to wheeze in pollen sensitive patients. 146 47

We investigated the relationship of three phenotypic markers of atopy (allergy skin test reactivity, serum IgE level, and eosinophilia) to the prevalence of respiratory symptoms in 1,071 middle-aged and older men participating in the Normative Aging Study. Participants had all been health screened at the onset of the study in the 1960s to exclude individuals with asthma or other chronic respiratory diseases. Respiratory symptoms were grouped into three categories: asthma (adult onset) and other wheezing syndromes; cough and phlegm production; and hay fever. Multivariate logistic regression models were utilized to assess the independent relationship of each phenotypic marker to symptom prevalence adjusted for age, cigarette smoking, and the competing influence of the other markers. In this population, the prevalence of each symptom increased with serum total IgE concentration, this relationship being strongest for asthma. Skin test positivity (greater than or equal to 5 mm induration to one or more aeroallergens) was strongly associated with hay fever but was not significantly associated with symptoms of wheeze or cough and phlegm. Eosinophilia was associated with asthma and with phlegm production. The association of eosinophilia with phlegm production was present in skin test-negative as well as skin test-positive subjects and remained significant even after current smokers and individuals with asthma or hay fever were excluded. These data support the concept that asthma and hay fever are related to different immunologic host factors as reflected by expression of atopy phenotypes. Future investigations of immunologic factors in respiratory disease susceptibility should include, at a minimum, an assessment of all three phenotypic markers of atopy.
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PMID:Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study. 192 48

Cessation of smoking in the home is one of the most important nonpharmacologic actions to be recommended. There is a highly significant increase in wheezing, coughing, and respiratory infections in children with smoking mothers, and this increase is directly proportional to the number of cigarettes smoked. Cord blood IgE levels are increased in babies whose mothers smoke during pregnancy. Other agents, such as sulpur dioxide and chemical pollutants from industrial processes may play a role in the development or exacerbation, of asthma symptoms and should be avoided. One of the most interesting areas in food allergy is whether breast feeding causes sensitization or induces tolerance in infants to foods ingested by the mother. There is an increase in asthma in second-generation immigrant populations who are exposed, from birth, to the Western style of living which increases their exposure to house dust mite. Several studies have shown that month of birth is important in the development of specific allergies, for example, in the incidence of birch pollen allergy in Scandinavia. The presence of a pet in the home at birth is associated with a greater incidence of allergy to that animal. Our study in asthmatic children has shown a strong association (p less than 0.001) between the presence of allergens in the air in their homes (sampled retrospectively in the month of birth) with a positive skin test to those allergens.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Nonpharmacologic means of preventing asthma. 211 30

The paper is concerned with diagnostic value provocation test with cold dry air and eucapnic hyperventilation for testing bronchial reactivity. Forty healthy subjects, 90 patients with bronchial asthma, 20 with chronic bronchitis, 2 with sarcoidosis, 14 with pollenosis, one with mucoviscidosis and 22 with dispnoa or long-lasting dry cough were tested. The total of 149 provocations have been carried out in patients and 40 in healthy subjects. Airways resistance after provocation with cold dry air and eucapnic hyperventilation in patients with bronchial asthma is increased over 100% in 13 (14%), over 200% in 12 (13%), over 300% in 25 (26%) and over 500% in 40 (47%) patients. Less intensive asthmatic attack was provoked in 14 (15%), moderate attack in 18 (20%) and severe attack in 58 (65%) patients with asthma. Provocation time lasted from 2 to 9.9 min. Inspired air temperature ranged from -23 degrees C to -26 degrees C. Airway resistance was measured before and after provocation by means of Bronchoscreen. Central airway resistance was increased in 2 patients, peripheral resistance in 78, and both resistances in 10 patients with bronchial asthma. The results pointed out that provocation with cold dry air and eucapnic hyperventilation resulted in bronchial hyperreactivity exclusively in patients with bronchial asthma, and the test was positive in 100% of patients with bronchial asthma.
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PMID:[Study of bronchial reactivity using dry, cold air and eucapnic hyperventilation]. 212 Jul 18

Respiratory symptomatology and pulmonary function tests were evaluated among 199 male Hutterites who utilized masks during farming and 159 Hutterites who did not use masks. Anthropometric and pulmonary function tests were comparable between the two groups. Symptomatology, including cough, phlegm, and wheezing were more prevalent among mask wearers compared to non-mask wearers. The prevalence of hayfever (p less than 0.02) and asthma (p less than 0.001) was greater among mask wearers vs non-mask wearers. Although the types and percent of individuals from each group raising crops and livestock were comparable, breathlessness, wheeze and fever were more common among the mask wearers. Thus farmers who suffered a higher incidence of symptoms as a consequence of farming are more likely to use masks.
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PMID:Utilization of masks by Hutterite farmers. 232 16

In a national study of almost 7000 primary school children, parents' perceptions were used to test the hypothesis that the child's irritability was associated with food intolerance independently of other symptoms. After adjustment in a multiple regression analysis for asthma or wheeze, cough, eczema, hives, diarrhoea and vomiting, rhinitis, hay fever and headache, and the social factors of father's social class, maternal education and maternal age, a highly significant association between perception of food intolerance and irritability (P less than 0.001) remained. Though we cannot rule out that irritable children's parents could be biased towards diagnosing food intolerance the possibility that some children do have behavioural disturbance associated with reactions to food needs to be explored further, preferably with a double blind challenge assessment.
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PMID:Associations of excessive irritability with common illnesses and food intolerance. 236 72


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