Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A role of nutrients in the onset of migraine and other gastrointestinal symptoms (vomiting, nausea, diarrhoea), skin reactions (rush, atopic dermatitis, Quincke'a edema), respiratory symptoms (bronchial asthma, cough, allergic rhinitis, polyps, congestion of the nasal mucosa), motion system disorders (jointache and edema), gynecological disorders (chronic and recurrent adnexitis), and sleep disorders together with emotional tension and behavioral disturbances has been assessed in 17 patients with atopy. Migraine attacks have been produced most frequently by cow milk (in 10 out of 17 patients), cabbage, flour and eggs in 5 patients, preservatives, cottage and Swiss cheese, porcine meat in 4 patients, colorants and chocolate in 3 patients, beef, strawberries, lemons and butter in 2 patients. Other nutrients produced headache in single patients. Migraine and other symptoms have diminished after an individual elimination diet. Recurrence has been noted after each consumption of allergen except one female patient with EEG abnormalities. Immunoglobulins E have been involved in headache-producing mechanism in 3 patients.
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PMID:[Migraine as one of the symptoms of food allergy]. 135 12

Atopic Dermatitis (AD) and asthma are closely associated with respect to epidemiology, hereditary factors and occurrence in the same individuals. Bronchial Hyperresponsiveness (BH), the hallmark of asthma, can also be a physiopathological feature of AD, even in the absence of clinical asthma. We studied 78 subjects with AD. A follow-up study was performed in 27 of these. Data on respiratory and dermatologic symptoms were collected by means of a standardized questionnaire. Skin reactivity was evaluated by prick testing, and in 57 subjects BH was assessed with a methacholine test (Mch). Twenty-one subjects had asthma and 36 showed a positive skin reaction. A PC20 FEV1 was measurable in 38 subjects. Males were found more likely to be Mch responders than females (p < 0.05). Mch responders also showed an earlier age at onset of AD than nonresponders (2.1 yrs vs. 6.2, p = 0.03). Determinants of the degree of BH were evaluated by a stepwise multiple regression analysis, taking the log of the slope of the concentration response curve as dependent variable. In the final model we found that the degree of BH was directly related to wheezing (p = 0.0017) and coughing (p = 0.04) and inversely related to lung function (p = 0.0082) and age (p = 0.0008). Neither skin reactivity nor grading of AD were statistically significant. The longitudinal study demonstrated that the courses of AD and BH seem to run parallel only in skin-negative subjects, whereas an increase in BH was observed in skin-positive subjects.
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PMID:The relationship between allergy, clinical symptoms and bronchial responsiveness in atopic dermatitis. 147 41

To evaluate the prophylactic effect of ketotifen against the onset of asthma we selected 121 infants with atopic dermatitis, without any history suggestive of asthma (cough and/or wheezing). Sixty-one children received ketotifen twice daily. Those who weighed less than 14 kg received 0.8 mg; 14 kg or more, 1.2 mg. Sixty children, a placebo syrup indistinguishable from the active syrup. Both groups were followed for 1 year, with bimonthly evaluations. The criteria for onset of asthma were two different episodes of wheezing treated with bronchodilator drugs. Both groups were comparable regarding age, sex, weight, onset, and duration of atopic dermatitis and age at the onset of asthma. During the 1 year study, asthma was observed in eight children of the ketotifen group (13.1%) and in 25 children of the placebo group (41.6%) (P less than .001). Side effects were negligible and routine laboratory tests disclosed no significant alterations. Ketotifen is a very useful drug for prevention of asthma in children with atopic dermatitis and total IgE more than 50 IU/mL.
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PMID:Prevention of asthma by ketotifen in infants with atopic dermatitis. 154 18

Immunotherapy with interleukin (IL)-2 possesses great potential in the treatment of immune-mediated diseases and cancers. However, only a few reports on a small number of children have appeared in the literature. From March 1988 to March 1989, 11 children and adolescents were treated with IL-2. They included 1 patient with hepatocellular carcinoma, 1 with hepatoblastoma, 6 with childhood atopic dermatitis, and 3 with juvenile rheumatoid arthritis. The dosages ranged from 10,000 to 50,000 U/kg every 8 hours by intravenous drip. The following side effects were observed: anorexia, fever, and chillness (100%), general malaise (82%), irritability (64%), diarrhea (100%), nausea and vomiting (73%), weight gain (82%), edema (82%), abdominal distension (73%), oliguria (82%), cough (91%), dyspnea (27%), pleural effusion (40%), hypotension (82%), skin eruption (82%), oral ulcer (18%), enlarged liver (73%) liver function abnormalities (82%), renal function impairment (36%), electrolyte imbalance (73%), anemia (91%), thrombocytopenia (54%), leukopenia (18%), and eosinophilia (73%). Immunologically, numbers of natural killer cells were increased and natural killer and lymphokine-activated killer cell activities were augmented after IL-2 treatment. There was a tendency for serum levels of IL-2 and receptor IL-2 to decrease, especially in patients with atopic eczema. Ten patients (91%) completed one course (9 to 12 days) of therapy, and the remaining patient interrupted the treatment because of intolerable adverse effects. Clinically, complete remission for 3 months was obtained in 1 juvenile rheumatoid arthritis patient, transient improvement (2 to 6 weeks) in all atopic dermatitis patients, minor response in the hepatoblastoma patient, and no response in the patient with hepatocellular carcinoma.
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PMID:Interleukin-2 immunotherapy in children. 217 36

p6tal blood eosinophil counts (TBE) were obtained in allergic and non-allergic patients suffering from asthma, rhinitis, cough, or various combinations of these disorders. As expected higher blood eosinophil counts were found in allergic patients. In the non-allergic patients however, significantly higher blood eosinophil counts were also found as compared to controls, which limits the possible role of TBE determination in the diagnosis of type I allergy. There is no significant correlation between TBE and total serum IgE. Atopic eczema is associated with higher TBE only in the group with allergic respiratory diseases. In allergic patients blood eosinophilia is steadily decreasing with age, where the inverse is observed in non-allergic patients. Our data suggest that for some reason TBE is increased in both allergic and non-allergic patients. A further increase of TBE in allergic patients is associated with a type I allergic reaction.
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PMID:Total blood eosinophilia in allergic (type I allergy) and non-allergic asthma, rhinitis and cough. 673 Dec 5

Serum immunoglobulin levels A, G, M, D have been studied in 902 patients suffering from allergic or non-allergic asthma, rhinitis and cough or various combinations of these disorders. In addition, a control group of asymptomatic persons was included. Serum IgA and IgD levels were significantly lower in both the allergic and non allergic groups of patients as compared to the control group, indicating that this decrease is a common feature for all patient groups studies. Serum IgA was significantly increased in amount in smokers. Serum IgA and IgG levels increased significantly with age. Females showed significantly higher serum IgM levels as compared to males. Atopic eczema did not seem to influence the serum level of immunoglobulin classes A, G, M or D.
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PMID:Serum IgA, IgG, IgM and IgD in allergic (type I) and non-allergic respiratory diseases. 683 83

Many reports describe an increase in the incidence of allergies in recent years. Thus the epidemiological studies are necessary for efficacious prophylaxis. The aim of our study was to estimate the prevalence of allergic diseases in schoolchildren. Allergic rhinitis and/or conjunctivitis was observed in 16.7%. Atopic dermatitis occurred in 12.9% cases. We showed the discrepancy between the number of children with symptoms suggestive for asthma (wheezing--11.1%, breathlessness--19.4%, nocturnal cough--4.9%, exercise-induced cough--9.8%) and number of cases diagnosed as asthma (3.2%). Family history of allergy increased the risk of allergic diseases in studied population.
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PMID:[Asthma, allergic rhinitis and atopic dermatitis in schoolchildren]. 764 27

Allergic diseases affect at least 15% of the population and are the cause of much ill-health. 'Clinical immunology and allergy', the term used by the Department of Health in England and Wales for this area of specialization, is recognized as a separate specialty of medicine under the National Health Service. Many organ-based hospital consultants (e.g. chest physicians) have allergy as a special interest or subspecialty. Allergists deal largely with 'itch, sneeze, cough and wheeze' and so are experts in: summer hay fever (seasonal, allergic, conjunctivorhinitis); perennial rhinitis (symptoms of a 'permanent cold'); allergic asthma (including occupational asthma); allergy to stinging insects (especially wasps and bees); allergy to drugs; allergy-related skin disorders, i.e. urticaria, angioedema, atopic eczema and contact dermatitis; food allergy and food intolerance; anaphylaxis (acute generalized allergic reaction); evaluating the role of allergy in non-specific/polysymptomatic illness. Children with allergic disease should be under the overall care of a paediatrician since the progression of allergies in children differs from that in adults. Good allergy practice involves teamwork by doctors, nurses and dietitians. The investigation of allergy patients includes skin tests and challenge procedures (e.g. food allergy tests) as well as various specialized laboratory investigations. Good clinical practice by providers and the effective use of allergy services by purchasers should improve prognosis and cut costs of treatment in allergic disease.
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PMID:Good allergy practice--standards of care for providers and purchasers of allergy services within the National Health Service. Royal College of Physicians and Royal College of Pathologists. 852 Nov 76

541 workers with long-term history of occupational contact with antibiotics and chemicals were examined by a dermatologist, ENT specialist, neuropathologist, surgeon, ophthalmologist. Many workers complained of occasional skin eruption, rhinitis, skin itching, sneezing, cough, Quincke's edema. Allergic examination revealed the presence of allergic symptoms (allergic dermatitis, itch, vasomotor rhinitis, chronic eczema, obstructive bronchitis, bronchial asthma, Quincke's edema, acute and chronic conjunctivitis) in 98 examinees. Somatic affections are represented by hypertension, chronic hepatitis, ulcer.
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PMID:[The effect of antibiotics on the body of those working in their manufacture]. 877

Case 1: A 26-year-old primipara, underwent emergency cesarean section because of premature rupture of membrane and breech presentation in her 36th week of gestation. She had no history of asthma, but physical examination revealed atopic dermatitis in the neck and the arms. Case 2: A 21-year-old woman underwent removal of ovarian cyst. She had a history of asthma in her childhood. On physical examination there was no abnormal findings. For both cases spinal anesthesia was uneventfully induced using 2 and 3 ml of 0.4% tetracaine in 10% dextrose respectively. Sensory loss to cold extended to T3 in both cases. Immediately after the anesthesia reached two level, the first patient began to cough and the second patient complained of difficulty in breathing, and then both became dyspneic in 10-15 minutes thereafter. Wheezing rhonchi was audible in both cases. Both patients recovered fully with antiasthmatic therapy. There was no shock, nor change of the skin and the mucosa. The baby also had no problem postoperatively. Skin reaction to intradermal injection of 0.025 ml of 0.4-0.00004% tetracaine in normal saline was tested on two patients and on eleven volunteers. At higher concentrations it resulted in positive in the patients and all the volunteers, and at lower concentrations it resulted in positive in case 2 and under-positive in case 1 and three volunteers having histories of allergic disease. Skin testing alone does not offer any diagnostic of tetracaine allergy, because tetracaine might be a chemical irritant. Thoracic adrenergic nerve blockade due to spinal anesthesia might trigger asthmatic attack by influencing the cholinergic ganglia of the lung and/or pulmonary blood flow.
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PMID:[Two cases of asthmatic attack caused by spinal anesthesia]. 896 38


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