Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Parents of children with cystic fibrosis have been reported to have a high prevalence of increased airway reactivity, but these studies were done in a select young, healthy, symptomless population. In the present study respiratory symptoms were examined in 315 unselected parents of children with cystic fibrosis and 162 parents of children with congenital heart disease (controls). The cardinal symptom of airway reactivity, wheezing, was somewhat more prevalent in cystic fibrosis parents than in controls, but for most subgroups this increased prevalence did not reach statistical significance. Among those who had never smoked, 38% of obligate heterozygotes for cystic fibrosis but only 25% of the controls reported wheezing (p less than 0.05). The cystic fibrosis parents who had never smoked but reported wheezing had lower FEV1 and FEF25-75, expressed as a percentage of the predicted value, than control parents; and an appreciable portion of the variance in pulmonary function was contributed by the interaction of heterozygosity for cystic fibrosis with wheezing. For cystic fibrosis parents, but not controls, the complaint of wheezing significantly contributed to the prediction of pulmonary function (FEV1 and FEF25-75). In addition, parents of children with cystic fibrosis reported having lung disease before the age of 16 more than twice as frequently as control parents. Other respiratory complaints, including dyspnoea, cough, bronchitis, and hay fever, were as common in controls as in cystic fibrosis heterozygotes. These data are consistent with the hypothesis that heterozygosity for cystic fibrosis is associated with increased airway reactivity and its symptoms, and that the cystic fibrosis heterozygotes who manifest airway reactivity and its symptoms may be at risk for poor pulmonary function.
 ...
PMID:Pulmonary abnormalities in obligate heterozygotes for cystic fibrosis. 343 35

18 patients with chronic obstructive bronchitis were treated with 900 mg myomycin a day. The clinical parameters examined were the quantity and organoleptic characteristics of the expectoration, coughing, and body temperature. These parameters were studied immediately before and 7.14 and 21 days after the start of treatment. Myomycin was found to be satisfactorily effective with minimal toxicity and well tolerated.
 ...
PMID:[Use of miocamycin in the acute exacerbation of chronic obstructive bronchopneumopathy. Case material contribution]. 349 53

Bronchitis in definition contains increased sputum production and cough. They gain importance through smoking and air-pollution. Both influences are good recordable. The last one is demonstrated by a regional air-monitor-net. Connections between air-pollution and airway diseases are seen in course-monitoring after pollution reducing actions. Essential complication of bronchitis as an airway disease in obstruction, airflow limitation. In small airways it runs at least synchronously. This obstruction is more sure and objective measureable than subjective complainted cough. This data, especially those of the flow-volume-loop, should have more weight. They correlate statistically significant in own studies in town-to-country differences to pollution, not to the only symptom of cough. Peak-Exspiratory-Flow and spirography show in comparison only a trend. The flow-rates might demonstrate more surely and objectively the environment-infrastructure in function data as possible cause for bronchitic airway diseases.
 ...
PMID:[Bronchitis and the environment--infrastructure]. 356 90

Respiratory tract disease was the main indication for surgery in 45 out of the 102 children operated upon for GER in the last 7 years: twenty-four had recurrent bronchitis and pneumonia, 18 had bronchitis with constriction (true asthma in 10), 2 had unbearable cough and 1 apnoeic crises. All had been medically treated before without success. The diagnosis of GER has been accepted only in patients with abnormal results in three or more of the following tests: barium swallow, extended pH-metering, manometry, endoscopy-biopsy and gastro-oesophageal scintigraphy. Nissen fundoplication cured GER in all cases, and its effect on respiratory tract disease after an average follow-up of 17 months (range 6 to 48) was rather encouraging: twenty-six children cured (57%), 9 improved (21%) and 10 remained unchanged (22%). Failures were more frequent in children with bronchoconstriction (45%) and in those without prior digestive symptoms (36%). Surgery is probably indicated more often in the treatment of respiratory tract diseases associated with GER in children than it was previously thought, but indications remain difficult and the results are uncertain in children with either asthma or bronchoconstriction.
 ...
PMID:[Results of surgical treatment of gastroesophageal reflux with respiratory manifestations]. 360 85

An 11-year-old Dalmatian was examined and treated for bilateral nasal discharge and cough of 6 months' duration. Response to medical treatment and surgical intervention was unsatisfactory. Histologic examination of lung tissue revealed chronic severe catarrhal bronchitis and bronchiolitis with bronchiectasis. Histologic findings and barium sulfate bronchography indicated abnormal mucociliary clearance in the respiratory tract. Electron microscopy revealed abnormalities or deletions of outer and/or inner dynein arms in 26% of the ciliary profiles from the affected dog. Similar abnormalities were not found in 500 ciliary profiles from age- and gender-matched control dogs.
 ...
PMID:Immotile cilia syndrome in an aged dog. 361 Jul 67

A case is presented of priapism resulting from disseminated intravascular coagulopathy (DIC), which was diagnosed by pathological studies of the amputated penis and skin biopsy. To our knowledge, this is the first case reported in Japan. This 72-year-old-man visited a hospital complaining of fever and cough, and was administrated for treatment of bronchitis and liver cirrhosis. A few days after admission, multiple purpura with edema and pain appeared over the skin regions on the bilateral knee joint, foot joint and upper extremities. A week after purpura appeared, priapism began. Regardless of irrigation and aspiration of corpora cavernosa and glans-cavernosa-fistula creation, penile necrosis developed. We had to perform penile amputation. The pathology of the amputated penis and skin, and blood coagulative examination suggested that DIC resulted in priapism. DIC was controllable by the use of FOY and heparin. He was discharged and is an outpatient.
 ...
PMID:[A case of priapism caused by disseminated intravascular coagulopathy]. 361 17

Reported here are the results from an ongoing study of outdoor air pollution and respiratory health of children living in six cities in the eastern and midwestern United States. The study enrolled 10,106 white preadolescent children between 1974 and 1977 in 3 successive annual visits to each city. Each child received a spirometric examination, and a parent completed a standard questionnaire. Of this cohort, 8,380 children were seen for a second examination 1 yr later. An air pollution monitoring program was begun in each community at about the time of the first examination. For this report, measurements of total suspended particulates (TSP), the sulfate fraction of TSP (TSO4), and sulfur dioxide (SO2) concentrations at study-affiliated outdoor stations were combined with measurements at other public and private monitoring sites to create a record of TSP, TSO4, and SO2 concentrations in each of 9 air pollution regions during the 1-yr period preceding each examination and, for TSP, during each child's lifetime up to the time of testing. Across the 6 cities, frequency of cough was significantly associated with the average of 24-h mean concentrations of all 3 air pollutants during the year preceding the health examination (p less than 0.01). Rates of bronchitis and a composite measure of lower respiratory illness were significantly associated with average particulate concentrations (p less than 0.05). In analyses restricted to lifetime residents, these outcomes were significantly associated with measures of lifetime mean TSP concentration. Within the cities, however, temporal and spatial variation in air pollutant concentrations and illness and symptom rates were not positively associated.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Effects of ambient sulfur oxides and suspended particles on respiratory health of preadolescent children. 370 94

The relationship between the common acute bronchitis syndrome and atopic disease was examined using a retrospective, case-control method. The charts of 116 acute bronchitis patients and of a control group of 60 patients with irritable colon syndrome were reviewed for evidence of previous and subsequent atopic disease or asthma. Bronchitis patients were more likely to have a previous history of asthma, a personal history or diagnosis of atopic disease, and more previous and subsequent visits for acute bronchitis. The main finding of the study was a tenfold increase in the subsequent visit rate for asthma in the acute bronchitis group. Thirty percent of patients with acute bronchitis made return visits for unresolved cough despite an 83 percent rate of antibiotic use. These findings challenge the common belief that the symptoms of acute bronchitis are solely infectious in origin and suggest the involvement of occult bronchospasm.
 ...
PMID:An association between acute bronchitis and asthma. 379 12

An epidemiological survey of 3216 primary school children living in the industrial, urban and rural areas of Singapore revealed a high prevalence of various respiratory symptoms and illnesses, with 13.1% cough, 8.2% wheezy chest, 25.9% blocked/running nose, 4.3% sinusitis, 7.8% asthmatic attacks and 4.1% bronchitis/pneumonia. Differences in the prevalence of respiratory illnesses and lung function tests were observed among children in the three areas, but this could not be accounted for by the varying air pollution levels which have been maintained below the long-term standards set up by WHO. It was probably responsible for the differences noted.
 ...
PMID:Prevalence of respiratory illnesses of school children in the industrial, urban and rural areas of Singapore. 381 Aug 38

In a working population of 912 men, aged 22 to 54 years, 8.3% reported a history of childhood respiratory illness before 16 years of age. Those reporting a history of bronchitis or pneumonia (BP) before 2 years of age had significantly lower FEV1 values than those who did not report such a history, whereas those reporting BP at a later age, or primary tuberculosis, did not have lower values. The observed association was unlikely to be due to preferential recall bias, since BP before 2 years of age was not associated with a higher reported prevalence of current respiratory symptoms of cough, phlegm, or dyspnea, and the observed association remained after exclusion of those with a history of wheezing or asthma. Furthermore, the relation remained significant after taking into account parental smoking, Pi phenotype and a history of eczema in childhood. These results suggest that BP before 2 years of age, a period of rapid alveolar multiplication, may be related to the occurrence of adult chronic air-flow limitation.
 ...
PMID:Relationships between functional measurements and childhood respiratory diseases according to the age of onset. 381 75


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>