Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 59-year-old woman had suffered cough and sputum production for several months. Chest x-ray film findings were negative, but sputum cytology yielded a diagnosis of squamous cell carcinoma. This stage Ia lung cancer in the right upper lobe bronchus was deemed inoperable due to poor cardiopulmonary function. She was treated by photodynamic therapy in February 1981, involving intravenous injection of hematoporphyrin derivative and fiberoptic endoscopically delivered argon dye laser light. She responded well to the treatment and the lesion disappeared within a week. At present, she is apparently disease-free more than five years after treatment. This is the first known report of five-year disease-free survival following treatment of a malignant lesion by PDT only.
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PMID:Five-year disease-free survival of a lung cancer patient treated only by photodynamic therapy. 376 83

A 25-year-old Japanese woman, complaining of catamenial hemoptysis and severe cough complicated with menorrhalgia, was diagnosed as having pulmonary and pelvic endometriosis. She was treated with danazol for 20 weeks. Significant improvement of her condition was achieved during the treatment period. Catamenial hemoptysis recurred at the first menstruation after termination of the treatment. Readministration of danazol was refused. Therefore, surgical removal of the affected lobe of the right lung was performed. Cases of this rare disorder are reviewed.
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PMID:A case of endometriosis of the lung treated with danazol. 402 19

This article reports a case of needlestick transmission of human T-lymphotropic virus type III (HTLV-III) infection to a health care worker in the UK from a patient who was presumably infected while in Africa. The patient, a white woman who had lived in central southern Africa, presented at the hospital with general malaise, dry cough, and fever. Lung biopsy revealed Pneumocystis carinii pneumonia infection, and the patient was seropositive for HTLV-III infection with a titer of 260. The patient reported that she had been unwell for 2-3 years. She had none of the accepted risk factors for acquired immunodeficiency syndrome (AIDS), and neither she nor her husband had visited the US, the Caribbean, or Zaire. Serum from the husband was positive for HTLV-III antibodies at a titer of 450. Despite intensive management and treatment with pentamidine, the patient died. During management of this case, a nursing staff member sustained a needlestick injury to the finger while resheathing a hypodermic needle. A small amount of blood was probably injected. 13 days later, the health care worker developed a severe flu-like illness with sore throat, headache, myalgia, and facial neuralgia. A macular rash and generalized lymphadenopathy were also noted. Serum drawn 27 days after the incident was negative for anti-HTLV-III infection, but titers on days 49 and 57 were 12 and 24, respectively. This contrasts with experience in the US, where needlestick injuries in health care workers have not resulted in either disease or transmission. It is assumed that the patient acquired AIDS in Africa, and that the infection was transmitted heterosexually. This case raises the possibility of differences in infectivity and other characteristics between HTLV-III viruses of US and African origin.
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PMID:Needlestick transmission of HTLV-III from a patient infected in Africa. 615 Mar 72

A case of congenital aneurysm of the left pulmonary artery in a 52-year-old Nigerian woman is presented. She presented with a transient history of cough and epigastric pains. A chest radiograph revealed a rounded left hilar mass just superior to the left main bronchus, and pulmonary angiography confirmed the presence of fusiform aneurysm of the left pulmonary artery. At cardiac catheterization, there was pulmonary hypertension (80 mmHg). There was no associated congenital cardiac malformation. The electrocardiograph showed right ventricular hypertrophy. The patient remains asymptomatic to date. This is the fourth known report of pulmonary aneurysm in an African. The rarity of pulmonary artery aneurysms is stressed.
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PMID:Congenital aneurysm of the pulmonary artery: a case report. 628 84

The first case report of Yersinia enterocolitica infection in Malaysia is presented. The patient was a 34-year-old Indian woman who had a four day history of fever, abdominal pain and cough and loose stools for 2 days. She was diagnosed and treated as a case, initially of bacillary dysentery, and then of urban typhus. She responded to tetracycline therapy. Bacteriological examination eventually resulted in the isolation and identification of Yersinia enterocolitica, serotype 0:3. This case indicates the presence of the infection in Malaysia although the incidence is probably very low. This appears to be the situation in 'warm' countries.
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PMID:Yersinia enterocolitica infection: first case report from Malaysia. 638 26

A 22-year-old woman is seen for progressive dyspnea on exertion experienced for the past six months. She has no dyspnea at rest, orthopnea, cough, or other symptoms. There is no history of heart murmurs, rheumatic fever, or pulmonary disease. Physical examination shows a healthy-appearing young woman with no cyanosis or clubbing. The jugular venous pulse shows a prominent A wave, with normal mean venous pressure. The lungs are clear to examination. The cardiac examination is normal except for a loud second heart sound that is narrowly split in expiration and a little more widely split in inspiration. The chest roentgenogram shows slight cardiac enlargement of nonspecific contour, with a considerably enlarged main pulmonary artery segment and moderately prominent central pulmonary artery branches. The peripheral lung fields are unremarkable. The electrocardiogram is shown.
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PMID:Dyspnea, right-axis deviation, and abnormal P waves in a young woman. 641 83

A patient with immunoblastic lymphadenopaty which evolved into immunoblastic sarcoma is reported. A 48-year-old female was admitted to our department because of cough and fever. A diagnosis of immunoblastic lymphadenopathy had been made two years before the present admission. Physical examination revealed generalized lymphadenopathy. Chest radiograms showed a left hilar mass. The pulmonary tumor and enlarged lymphnodes were treated by irradiation. Although there was marked improvement at first, she experienced several relapses. One year after the admission, chest radiograms showed multiple pulmonary lesions. She developed pancytopenia and bone metastases. At autopsy, the lymphnodes showed histological evidence of immunoblastic sarcoma; a pulmonary lesion showed immunoblastic lymphadenopathy.
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PMID:[Case of immunoblastic sarcoma (IBS)]. 664 66

A 41-yr-old psychologically disturbed woman presented with attacks of paroxystic dyspnea, laborious expiration, cough, and expiratory wheezing. She had been treated for bronchial asthma and had developed an iatrogenic Cushing's syndrome. Wheezing had maximal intensity over the larynx, and fiberoptic bronchoscopy showed an almost closed glottis orifice during its production. Lung function tests were normal both before and during the attacks. Inhalation challenge tests with acetylcholine and histamine were negative. During the attacks the patient breathed near residual volume, and tidal flows reached the maximal flow-volume envelope. We suggest that wheezing was produced by high flows passing through a narrow glottis orifice. The association of expiratory wheezing of laryngeal origin with normal overall lung function should be kept in mind, because it can be easily confounded with bronchial asthma, and result in therapeutic errors.
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PMID:Emotional laryngeal wheezing: a new syndrome. 683 58

A primary chondrosarcoma of the right main bronchus was removed by pneumonectomy in a 74-year-old woman. The presenting symptoms were dyspnea and cough with a lung mass evident for 18 months. She is well and free of tumor 16 months later. Only eight established cases of primary chondrosarcoma arising from the lung, and four originating from the tracheobronchial tree have been previously described. The long preoperative history and the outcome so far confirm the relatively less aggressive character of the tracheobronchial as compared to the lung subdivision of primary pulmonary chondrosarcoma.
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PMID:Chondrosarcoma of the bronchus. 687 6

The usual presenting features of vitamin A intoxication are pseuotumor cerebri, skeletal pain, desquamative dermatitis, and hepatic inflammation. Our patient was a nine-year-old female who had increasing cough, dyspnea, and abdominal distention for a short time prior to admission. She was said to have been treated with 10,000 units of vitamin A per day for skin rashes. Radiographic studies revealed a very large right sided pleural effusion, ascites, demineralized bones, and retarded skeletal maturation. The diagnosis of hypervitaminosis A was made. More detailed medical history confirmed that the child had, in actuality, received up to 300,000 units/day of vitamin A plus desiccated liver pills and carrot juice for the previous year. Clinical symptoms completely abated following acute medical treatment for ascites and cessation of vitamin A intake. Several months later, a sample of liver, obtained and preserved at the time of exploratory laparotomy, was homogenized and extracted with ethanol/hexane. The retinyl palmitate level was significantly elevated and consistent with vitamin A poisoning.
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PMID:Pleural effusion and ascites: unusual presenting features in a pediatric patient with vitamin A intoxication. 708 15


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