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Clinical signs and haematological findings during the acute and convalescent phases of an infection with bovine respiratory syncytial virus (RSV) were studied under field conditions. The study was carried out in 139 cattle less than 16 months of age in 16 herds with serologically proven bovine RSV infections. Blood was collected for serological and haematological examination. Repeated clinical examinations were carried out until 35 days after appearance of disease. Signs of general disease such as reduced appetite and a body temperature of 40 degrees C or higher lasted less than three days in most cases. Signs of upper respiratory disease, such as coughing, nasal discharge and conjunctivitis were predominant and persisted in 10 to 30 per cent of the animals till the end of the observation period. Signs of lower respiratory disease such as abdominal breathing, bronchial and bronchovesicular sounds on auscultation and a high respiration rate were valuable in diagnosing the disease. These symptoms were present in about 50 per cent of the animals in the early stages of the disease. They lasted for about six days and disappeared in most animals after about 10 days. On haematological examination statistically significant blood changes were observed. A rise in zinc and iron between day 0 and day 10 and a reduction in copper content between day 10 and day 21 were found.
Vet Rec 1984 Jan 07
PMID:Bovine respiratory syncytial virus infections in young dairy cattle: clinical and haematological findings. 670 77

An acute pneumonia developed in 28 calves which had been housed together from one to two weeks of age. The clinical signs included pyrexia, tachypnoea, respiratory distress and coughing. Some of the calves died. The pneumonia was characterised by an alveolitis with multinucleated syncytia, alveolar epithelial hyperplasia and bronchiolitis. Interstitial emphysema was also present. Fifteen of 19 calves examined serologically had rising neutralising antibody titres to respiratory syncytial virus; in nine calves the rise was fourfold or greater. Respiratory syncytial virus was not isolated from the calves. There was no evidence of parainfluenza type 3 virus involvement. The adult cows being sucked by the calves remained clinically normal throughout the incident. Six calves examined six weeks after the outbreak started had a chronic cuffing pneumonia characterised by lymphocytic bronchiolitis; some of the calves also had bronchiolitis obliterans. Mycoplasma dispar was found in two of them.
Vet Rec 1981 May 09
PMID:Acute fatal pneumonia in calves due to respiratory syncytial virus. 725 27

A two-year-old rough collie bitch with a five-week history of excess salivation, coughing and dysphagia was examined. The dog had bilateral sensory loss over the whole trigeminal field while motor function of the fifth cranial nerve was preserved. No other neurological abnormalities were detected. The dog was observed over 18 months during which the condition did not progress. It was destroyed 18 months after the onset of trigeminal signs following development of a systemic illness, refractory to treatment and unrelated to the neurological signs. Pathological abnormalities were limited to the three major branches of both fifth nerves and the gasserian ganglia. There was partial loss of myelinated nerve fibres in each branch and also in the spinal tract of the fifth nerve in the brain stem. It was considered that the primary abnormality was in the gasserian ganglion and that the fibre loss was secondary to the neuronal lesion in the ganglia. The motor nucleus of the fifth nerve was normal. No cause could be found for this isolated sensory neuropathy of the trigeminal nerve.
Vet Rec 1981 Sep 26
PMID:Case of isolated sensory trigeminal neuropathy in a dog. 733 27

The occurrence of inflammatory nasopharyngeal polyps is described in a series of four cats. Two of the cats presented with classical features of chronic upper respiratory tract infection, in a third gradual onset of coughing and retching were the only clinical signs, while in the fourth only noisy respiration accompanied the growth. In each cat the polyp was attached to the pharyngeal opening of the eustachian tube and it is suggested that such masses arise from either the lining of the tube itself or that they may even find origin within the tympanic bulla. However, anamnesis and the subsequent clinical and radiographic examinations did not indicate that the polyps were associated with external or middle ear disease. Removal by simple dissection was effected without the necessity of splitting the soft palate in any of the patients and, though expected, recurrence has not yet been seen.
Vet Rec 1981 Dec 19
PMID:Nasopharyngeal polyps in the cat. 733 43

Fifteen incidents of infectious bovine rhinotracheitis (IBR) were studied in herds distributed widely throughout northern Britain. Fattening beef animals (10 outbreaks), dairy cattle (four outbreaks) and suckler beef cows (one outbreak) were affected and all bar one incident occurred in housed cattle during the winter. The first signs of illness noticed were a reduced appetite, dullness, coughing and oculonasal discharge. In 13 of the incidents they were observed in cattle purchased from a market within the previous four weeks. In every outbreak, affected animals developed a serous nasal discharge which became purulent in severe cases. In the early stages the nasal mucosa was congested but later yellow-brown diphtheritic plaques developed. In such animals halitosis was always detected. Soft coughing was frequently heard but pneumonia was rarely confirmed ante mortem. Conjunctivitis and ocular discharge were a major finding in 13 incidents and, in severely affected cases, conjunctival oedema was seen. The drooling of saliva was noticed in 14 incidents but congestion of the oral mucous membranes was the only abnormality found on examination of the oral cavity. Diarrhoea was a consistent feature in one outbreak. As a result of contracting this disease beef cattle failed to put on weight for a period of one to eight weeks and the milk yield of lactating dairy cattle decreased markedly. The morbidity rate was high, being more than 90 per cent in 10 incidents. The mortality rate varied considerably but 7 to 8 per cent of the animals died, or were culled, in three outbreaks. The clinical signs were most severe on intensive units with a high turnover of cattle.
Vet Rec 1980 Nov 08
PMID:Clinical and epidemiological features of 15 incidents of severe infectious bovine rhinotracheitis. 745 95

Seven previously untreated five-month-old New Forest ponies received two doses of equine influenza immunostimulating complex vaccines, one with and one without an immunopurified tetanus toxoid component, given by deep intramuscular injection six weeks apart, followed by a booster dose without tetanus toxoid five months later. Fifteen months after the third dose of vaccine, the ponies were challenged by exposure to an aerosol of influenza A/Equine 2/Sussex/89 (H3N8), a virus isolated from a recent outbreak of influenza A/equine 2 in Britain. The challenge produced severe clinical signs of influenza (pyrexia and coughing) in five unvaccinated control ponies. Four of the vaccinated ponies were completely protected against clinical disease, and two of these were also protected against infection as demonstrated by their lack of an antibody response after challenge. No coughing was recorded among the vaccinated ponies, and only three of the seven vaccinated ponies experienced a transient mild pyrexia. The mean duration and severity of the pyrexia among the vaccinated ponies was significantly less (P < 0.01) than among the controls, and the excretion of virus was almost eliminated, thus demonstrating the protective efficacy of the vaccines 15 months after vaccination. Monitoring of tetanus antitoxin antibodies showed that protective levels (> or = 0.01/iu/ml) were maintained for at least 20 months after vaccination.
Vet Rec 1994 Feb 12
PMID:Duration of protective efficacy of equine influenza immunostimulating complex/tetanus vaccines. 816 Mar 28

Four eight-week-old cats, shown to be free from feline calicivirus, feline herpesvirus and Chlamydia psittaci were challenged with an aerosol of Bordetella bronchiseptica. Within five days the cats developed signs of respiratory disease, characterised by nasal discharge, sneezing, spontaneous or induced coughing and dry or wet rales at auscultation. These signs were present for about 10 days, after which they began to resolve. To test the protective capacity of an experimental fimbrial antigen-based subunit vaccine, 10 kittens were vaccinated twice, with two weeks between the vaccinations, and five kittens were left unvaccinated. Two weeks after the booster the 15 kittens were challenged with an aerosol of B bronchiseptica as the sole pathogen. On the day of challenge the vaccinated kittens had a mean bordetella antibody titre of 2(9.5) whereas the control cats remained seronegative (titre < 2(2)). The control cats developed signs of respiratory disease after challenge, whereas the vaccinated cats were almost completely protected. The degrees of protection against rhinitis, sneezing, spontaneous or induced coughing, and dry or wet rales at auscultation were 100 per cent, 95 per cent, 95 per cent and 100 per cent, respectively. Furthermore, the vaccinated kittens cleared the challenge bacteria more quickly than the controls, resulting in a reduction of 80 per cent on days 15 and 18 after challenge and a reduction of 99 per cent on days 22 and 29 after challenge. The results show that B bronchiseptica can act as a primary pathogen in cats and that a vaccine containing the fimbrial antigen induces a protective immune response.
Vet Rec 1993 Sep 11
PMID:Feline bordetellosis: challenge and vaccine studies. 823 48

The occurrence of winter dysentery, diagnosed by farmers and defined as an outbreak of diarrhoea among at least 30 per cent of adult cattle in a herd, was monitored in 256 dairy herds in an area of central Sweden. The cumulative incidence of winter dysentery between April 1988 and March 1989 was 28.5 per cent. A typical outbreak lasted for one to two weeks and 74 per cent of the outbreaks occurred between November and January. A decrease in milk yield was reported in 90 per cent of the affected herds and the cows showed respiratory signs in 57 per cent of them. There was a significant (P < 0.05) association between the occurrence of fever and coughing. In 31 per cent of the outbreaks the farmer also noticed diarrhoea among the calves. One-third of the affected herds had experienced an outbreak within the previous four years and 18 per cent had at least one further outbreak during the following two years. There was a significantly (P < 0.05) lower disease score in herds that had had an outbreak within the previous four years than in herds which had had a less recent or no previous outbreak, indicating the development of temporary immunity to the causative agent.
Vet Rec 1993 Sep 25
PMID:Winter dysentery diagnosed by farmers in dairy herds in central Sweden: incidence, clinical signs and protective immunity. 823 67

Angiostrongylus vasorum infection was diagnosed in six dogs by the identification of larvae in sputum or faeces, or by the identification of adult worms post mortem. In another dog strong evidence of the condition was obtained but no parasites were identified. In four cases the main clinical signs were coughing and dyspnoea, but one dog had exercise intolerance and no history of coughing. One dog in which larvae were found in the faeces had no clinical signs that were related to the infection. Another dog had flaccid hindlimb paralysis and forelimb hypermetria-clinical signs of the disease which have not been reported previously. Four of the cases came from south Wales, one of them being the first case of the infection to be reported from this area.
Vet Rec 1993 Dec 04
PMID:Angiostrongylus vasorum infection in seven dogs. 830 6

An H1N1 strain of influenza virus (A/swine/England/195852/92) isolated recently from clinical epizootics in pigs was transmitted experimentally to six-week-old specific pathogen-free pigs. Between one and four days after inoculation the infected pigs developed pyrexia and showed signs of coughing, sneezing and anorexia. Seroconversion was detected seven days after infection. Virus was isolated from nasal swabs and tissues up to four days after infection, but was not recovered from faeces. Virus was isolated from serum samples taken from each infected animal for a period of only one day between one and three days after infection. The pathology was characterised by a widespread interstitial pneumonia for up to 21 days after infection, lesions in the bronchi and bronchioles for up to seven days after infection, and haemorrhagic lymph nodes. Epithelial damage in the bronchial generations as a result of the virus infection was demonstrated by immunocytochemistry and electron microscopy.
Vet Rec 1993 Jun 12
PMID:Pathogenicity of a swine influenza H1N1 virus antigenically distinguishable from classical and European strains. 839 25


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