Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0009952 (febrile convulsions)
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Human Gene/Protein
zinc finger protein 135 14.7
AP3M2 13.7
ZFEND 13.7
CSS2 13.4
SCNB1 12.7
CPA6 12.1
SEZ6 11.9
CSS1 11.7
GPR98 11.6
GABRG2 11.6
KCNMB3 11.5
SCN1B 11.5
P-Rex2 10.6
Coagulation factor VII 10.6
PRRT2 10.5
SCN1A 10.5
GABRE 10.4
KCNMB2 10.4
CMR1 10.2
XLIS 10.1
CIRL 10.0
contactin 4 9.9
subtype EP3 9.9
Nav1.1 9.8
ANO3 9.7
GABRD 9.6
protocadherin 19 9.6
Coagulation factor V 9.5
CNTN4 9.5
syntaxin 7 9.4
FGF13 9.3
ASIC4 9.3
KCNC3 9.0
Interleukin-26 9.0
syntaxin 1B 8.9
IFI44L 8.9
EMP1 8.8
SLC6A8 8.7
PCDH19 8.6
sodium channel alpha-subunit 8.4
CPT II 8.4
fukutin 8.4
SCN9A 8.4
LGS 8.3
Grb14 8.3
EMX2 8.2
KCNQ3 8.2
P66 8.1
ORM 8.1
HLA-antigen 8.1
zinc transporter 3 8.1
LGI1 8.0
RIPK2 7.9
voltage-gated sodium channel 7.9
creatine transporter 7.9
HRC 7.9
SCN8A 7.8
neuronal nicotinic acetylcholine receptor 7.7
guanidinoacetate methyltransferase 7.6
Cav1.3 7.5
NCX3 7.4
HCN1 7.4
HBA 7.4
RTS 7.4
P36 7.3
CPT2 7.3
GAD1 7.3
KCNQ2 7.3
CASP1 7.2
CHRNA4 7.2
protein kinase C epsilon 7.1
G16 7.1
Fukuyama-type congenital muscular dystrophy 7.0
HCN2 7.0
CT1 6.9
IGFBP7 6.9
HLA-A11 6.9
glycine amidinotransferase 6.9
KCNQ4 6.9
KCC2 6.9
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Disease
FEB5 14.7
FEB6 14.7
febrile convulsions 14.7
FEB4 14.5
FEB2 14.3
FEB3 14.2
FEB1 13.9
Complex febrile convulsions 13.7
Secondary generalized epilepsy 12.7
GEFS+ 12.2
FTLE 12.1
Atypical benign partial epilepsy 11.9
Hemiconvulsion-hemiplegia-epilepsy syndrome 11.9
Benign myoclonic epilepsy in infancy 11.9
psychomotor disorder 11.7
Malonyl-CoA decarboxylase deficiency 11.7
Generalized epilepsy 11.6
Recurrent seizures 11.1
Colpocephaly 11.0
Brainstem encephalitis 10.9
ABPE 10.7
roseola infantum 10.6
XLIS 10.4
Acute encephalopathy 10.3
psychomotor epilepsy 10.3
Convulsive status epilepticus 10.1
Idiopathic epilepsy 9.8
Hippocampal sclerosis 9.8
grand mal epilepsy 9.8
viral pharyngitis 9.7
roseola 9.5
enterovirus meningitis 9.5
aphemia 9.4
Lennox syndrome 9.3
SUDEP 9.3
Water intoxication 9.1
myeloradiculitis 9.1
nervous system infection 8.9
temporal lobe epilepsy 8.8
pseudopelade 8.7
infectious encephalitis 8.6
acute suppurative otitis media 8.6
petit mal 8.5
minimal brain dysfunction 8.5
mumps meningitis 8.5
Influenza A virus infection 8.4
Temporal lobe 8.3
juvenile myoclonic epilepsy 8.2
Sepsis-associated encephalopathy 8.2
viral meningitis 8.1
schizencephaly 8.1
Microscopic polyangiitis 8.1
coryza 8.0
status epilepticus 8.0
complex partial seizures 8.0
Lennox-Gastaut syndrome 8.0
alcohol effect 7.9
Ohtahara syndrome 7.8
brittle hair 7.8
fits 7.8
Cerebral malaria 7.8
myoclonus epilepsy 7.8
Lennox-Gastaut syndrome 7.7
epilepsy 7.7
Haemophilus influenzae meningitis 7.6
leukoencephalitis 7.6
Acute stress disorder 7.5
generalized seizure 7.5
SFS 7.5
Fukuyama congenital muscular dystrophy 7.5
Neonatal seizures 7.4
IGE 7.4
aseptic meningitis 7.4
LGS 7.4
common migraine 7.3
Frontal lobe 7.3
focal epilepsy 7.3
idiopathic disorder 7.3
bacterial meningitis 7.3
pachygyria 7.2
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Symptom
Drug withdrawal symptoms 13.7
Facial grimacing 13.1
disturbed speech 10.7
Todd's paralysis 9.3
partial seizure 8.1
tonic-clonic seizure 8.0
seizures 8.0
tonic seizure 8.0
clumsiness 7.2
Extrapyramidal symptoms 7.1
athetosis 6.6
visual hallucination 6.5
Excitability 6.3
Physical findings 6.3
meningism 6.3
clonus 6.2
consciousness disturbance 6.0
Respiratory symptoms 5.8
enuresis 5.6
ataxic gait 5.6
retching 5.6
breath holding 5.5
Gastrointestinal symptoms 5.5
halitosis 5.5
neck stiffness 5.4
myoclonus 5.4
twitching 5.3
hypocapnia 4.9
hypotonia 4.7
hemiplegia 4.7
hot flashes 4.6
sleepiness 4.6
pallor 4.4
syncope 4.3
paraparesis 4.2
wheezing 4.0
dystonia 4.0
cough 3.9
vomiting 3.9
cerebellar ataxia 3.9
sneezing 3.8
fever of unknown origin 3.7
chorea 3.6
rhinorrhea 3.5
arthralgia 3.5
knee pain 3.2
lethargy 3.2
hepatomegaly 3.2
ataxia 3.0
myalgia 3.0
headache 2.8
cyanosis 2.8
dysarthria 2.8
hypercapnia 2.7
hypothermia 2.6
diarrhea 2.6
respiratory distress 2.4
paresthesia 2.4
hyperoxia 2.3
ENT 2.3
weakness 2.3
cachexia 2.2
agitation 2.1
erythema 2.0
anorexia 1.9
vertigo 1.9
spasm 1.8
low back pain 1.4
abdominal pain 1.3
Ill 1.2
thinning 1.2
stigma 1.0
tremor 0.5
discomfort 0.2
discomfort 0.1
starvation 0.1
analgesia -0.1
collapse -0.1
pain -0.3
anesthesia -0.5
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Drug
Chiron-Behring 14.7
Diastat 10.2
Pertussis vaccine 9.0
Stiripentol 8.9
APM 7.2
Camphor 7.1
Camphor 7.0
Bezafibrate 6.6
Sodium valproate 6.4
Lugol 6.0
Bumetanide 6.0
Imiquimod 5.6
DPA 5.4
Phenytoin 5.3
Ganciclovir 5.1
Gastro 4.9
DDAVP 4.8
DDAVP 4.7
Acyclovir 4.7
BCG vaccine 4.5
CSF 4.2
TTC 3.8
Fructose 3.8
Theophylline 3.7
Frontal 3.7
EPI 3.6
Histamine 3.2
Albumin 2.4
ampicillin 1.6
ENT 1.6
caffeine 1.3
Monit 1.2
Asthma 1.0
lysine 0.8
NADH 0.3
IL-2 -0.2
Dermatol -3.3
Enzyme
guanidinoacetate methyltransferase 7.6
glycine amidinotransferase 7.4
CGT 5.9
lactic acid dehydrogenase 5.8
lactic acid dehydrogenase 5.8
E-2 5.2
lactic acid dehydrogenase 5.1
GABA transaminase 5.0
SPS 5.0
PTPase 4.7
nucleotidase 4.7
glutamate decarboxylase 4.6
CPS 4.4
histidine decarboxylase 4.2
CPT 4.1
5'-nucleotidase 4.0
prostaglandin synthetase 3.8
ADH 3.6
CPT 3.0
CPT 2.9
pyruvate dehydrogenase 2.9
pyruvate dehydrogenase 2.9
enolase 2.8
arginase 2.8
adenosine deaminase 2.4
adenosine deaminase 2.3
pyruvate dehydrogenase 2.3
AST 2.1
caspase-1 2.1
creatine kinase 2.1
choline acetyltransferase 2.1
GSK 1.9
alanine aminotransferase 1.6
alcohol dehydrogenase 1.5
glutathione reductase 1.5
adenylate cyclase 1.4
cholinesterase 1.0
acetylcholinesterase 0.9
lactate dehydrogenase 0.8
aspartate aminotransferase 0.3
glutathione peroxidase 0.3
glutathione S-transferase 0.2
catalase -0.1
proteasome -0.1
superoxide dismutase -0.2
caspase-3 -0.4
alkaline phosphatase -0.9
protein kinase -1.6
mitogen-activated protein kinase -1.9
Compound
FC 43 10.0
3-Hydroxykynurenine 9.3
Clobazam 9.1
BNS 9.0
Methyllycaconitine 8.6
3-Hydroxykynurenine 8.4
Nitrazepam 7.0
Camphor 7.0
DHF 6.8
Luminal 6.8
Cystathionine 6.5
Cystathionine 6.5
Paeoniflorin 6.5
Methyllycaconitine 6.4
Valproic acid 6.3
Clomipramine 6.0
Clonazepam 5.9
DTP 5.8
Cannabidiol 5.8
Amantadine 5.7
Amantadine 5.7
Flumazenil 5.7
Amantadine 5.6
Topiramate 5.4
PYR 5.3
Amantadine 5.3
DPT 5.3
HSO 5.3
Lamotrigine 5.1
Benin 5.1
SAH 5.0
APAP 4.9
Diazepam 4.8
TCC 4.8
gamma-aminobutyric acid 4.8
T 1 4.7
Acyclovir 4.7
Valproic acid 4.7
neopterin 4.7
Creatine 4.6
N-acetylaspartate 4.6
DPA 4.6
DPA 4.6
methylhistamine 4.6
SET 4.5
Vasopressin 4.5
Midazolam 4.5
DPA 4.4
DPH 4.4
DPA 4.4
DPA 4.4
MCH 4.3
DPA 4.2
DPA 4.2
Tetrodotoxin 4.1
DPA 4.1
DPA 4.1
DPA 4.1
DPA 4.1
DPA 4.1
folinic acid 3.9
Ibuprofen 3.9
GABA 3.8
GABA 3.8
hydroxyindoleacetic acid 3.7
Glutamine 3.7
Fructose 3.7
TTC 3.5
Taurine 3.5
6-12 3.5
Leucine 3.4
MTS 3.3
Lactic acid 3.3
Austin 3.3
S-adenosylhomocysteine 3.2
Theophylline 3.2
Neuronal 3.2
Histamine 3.2
Oxytocin 3.2
Guo 3.1
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