Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0009952 (febrile convulsions)
 1,215 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The question whether personal or family history of convulsions is a contraindication to pertussis vaccine is answered by recommendations of the Immunization Practices Advisory Committee. It is known that infants and young children who have had febrile or non-febrile convulsions are more likely to have convulsions after pertussis vaccine. A family history of seizures is not associated with such convulsions, however. In the U.S., risk of contracting pertussis is low, so pertussis vaccine can be deferred, and only DT (diphtheria-tetanus toxoid) inoculations can be offered until it is determined whether a neurological disorder is evolving. The procedure of evaluating seizures in children given pertussis vaccine is presented in a flow diagram. First, if the convulsions occur within 48 hours after a DPT dose, DT should be given. If a 3rd dose of DPT has been administered, and at least 6 months have elapsed since the last convulsion, DPT can be continued. If either case applies, a thorough physical exam and history, with lab tests should be done to evaluate whether an evolving neurological disorder is present: if not, DPT can be continued. A minimum of 3 doses of DPT at 4 week intervals is necessary to protect against whooping cough. Other contraindications include hypersensitivity to the vaccine and a severe reaction such as shock, persistent screaming, fever over 40.5 degrees C., or serious neurological symptoms. There is no evidence for a link between thrombocytopenic purpura or hemolytic anemia and pertussis vaccine.
EPI Newsl 1984 Aug
PMID:Contraindications to pertussis vaccine. 1228 Dec 68