Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UMLS:C0009952 (
febrile convulsions
)
1,215
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Febrile seizure
(FS) counts as the most common seizures symptom in children undergoing recurrent seizures, posing a high risk to developing subsequent temporal lobe epilepsy. Canonical transient receptor potential channel (TRPC) members are identified as the FS-related genes in hyperthermia prone rats. However, the role of
TRPC3
in hyperthermia-induced FS rats remains unclear. In the present study, we investigated whether
TRPC3
functionally contributes to the development of FSs. Elevated
TRPC3
mRNA and protein levels was detected in hyperthermia-induced FS rats and rat hippocampal neuron cells. The specific inhibitor of
TRPC3
, Pyr3, remarkably attenuated the susceptibility and severity of seizures, neuronal cell death, and neuroinflammation in FS rats. Conversely, NCX3 activation was apparently suppressed in rats subjected to recurrent FS and rat hippocampal neuron cells. The expression of NCX3 was up-regulated after
TRPC3
inhibition in vivo and in vitro. Furthermore, an interaction between
TRPC3
and NCX3 was detected by co-immunoprecipitation. Inhibition of
TRPC3
suppressed intracellular Ca
2+
levels in hyperthermia-treated hippocampal neuronal cells. In conclusion, our findings supported that
TRPC3
functions as a critical regulator of seizure susceptibility and targeting
TRPC3
may be a new therapeutic strategy for FS.
...
PMID:Canonical Transient Receptor Potential Channel 3 Contributes to Febrile Seizure Inducing Neuronal Cell Death and Neuroinflammation. 2974 35
