Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0009952 (febrile convulsions)
 1,215 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The unusual high frequency of adolescence onset epilepsy (100 cases of 334 patients) has been revealed. The finding is explained by prevalence of patients with drug resistant epilepsy in the sample investigated. Therefore, adolescence onset epilepsy appears to have poor outcome. Significant difference (p < 0.05) was found between girls and boys. The latter experience febrile convulsions, parasomnia more frequently with prevailing assynchronic attacks and alcohol abuse and sleep deprivation as precipitating factors. The dynamics and prognosis of age-dependent epilepsy types are presented.
 ...
PMID:[Epilepsy in adolescents]. 1237 89

ABSTRACT Two children with major depression experienced the emergence of motor and vocal tics after 2-3 weeks on imipramine at doses of 75-100 mg daily. The tics did not show any sign of subsiding for 9-10 days following the discontinuation of imipramine, but subsequently responded to treatment with haloperidol. Case 1 involved an 8-year-old child with depression, attention-deficit hyperactivity disorder (ADHD), other behavioral problems, and a history of a single febrile seizure. His family history was positive for tics, depression, anxiety, and seizures. He was found to have a toxic plasma level of the tricyclic antidepressant. Case 2 involved a 13-year-old child with depression, ADHD, behavioral problems, obsessive compulsive symptoms, intellectual deficit, developmental delays, grand mal seizures, and concomitant use of phenytoin. The child had previously developed tics while receiving methylphenidate. The family history was positive for tics, depression, obsessive compulsive symptoms, suicide, and alcohol abuse. The child had a subtherapeutic plasma level of the antidepressant. It is suggested that tricyclic antidepressants may precipitate tics consistent with the symptoms of Tourette's syndrome in genetically vulnerable children. Although this possibility has been suggested in the literature, these are the first two documented cases of this phenomenon. Speculating from these two cases, ADHD may be a risk factor for the appearance of imipramine-induced tic symptoms in depressed children.
 ...
PMID:Emergence of motor and vocal tics during imipramine administration in two children. 1963 Jun 34

Since Hong Kong is highly urbanized and acute public hospitals have been established across the city, most patients with unprovoked seizures not already receiving antiepileptic drug (AED) therapy, particularly convulsive seizures, will be admitted as emergency for assessment. A thorough history is taken from the patient and any witnesses to the seizure. This includes the circumstance of the seizures, detailed symptoms and signs experienced by the patient and witnessed by others before, during, and after the seizure, any potential precipitating factors, history of previous seizures (that the patient might have overlooked), and history of previous brain insults that might have increased the risk of epilepsy later in life, including gestational and birth history, history of childhood febrile seizure, significant head trauma, any family history of epilepsy or seizures, comorbidities, current medications, drug and alcohol abuse, and social history including employment, driving, and living circumstances. A detailed physical and neurologic examination is performed.
 ...
PMID:What is the standard approach to assessment of an unprovoked seizure in an adult?: HONG KONG. 2363 74