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Gross anatomical features and a complex set of vascular changes characterize schistosomal hepatopathy as a peculiar form of chronic liver disease, clinically known as "hepatosplenic schistosomiasis". It differs from hepatic cirrhosis, although clinical and pathological aspects may sometimes induce confusion between these two conditions. Intrahepatic portal vein obstruction and compensatory arterial hypertrophy render the hepatic parenchyma vulnerable to ischemic insult. This may lead to focal necrosis, which may give place to focal post-necrotic scars. These events are of paramount importance for the clinico-pathological evolution of schistosomal hepatopathy. Although portal fibrosis due to schistosomiasis sometimes reveals numerous myofibroblasts, it does not mean that such fibrosis belongs to a peculiar type. Damage to the muscular walls of the portal vein may be followed by dissociation of smooth muscle cells and their transition toward myofibroblasts, which appear only as transient cells in schistosomal portal fibrosis. Studies made with plastic vascular casts, especially those with the murine model of "pipestem" fibrosis have helped to reveal the mechanisms involved in systematized portal fibrosis formation. However, the factors involved in the pathogenesis of hepatosplenic disease remain poorly understood. A process of chronic hepatitis is a common accompaniment of portal fibrosis in schistosomiasis. Most of the times it is caused by concomitant viral infection. However, no special interaction seems to exist between schistosomal hepatopathy and viral hepatitis.
Mem Inst Oswaldo Cruz 2004
PMID:Schistosomal hepatopathy. 1548 35

We judge the worth of a scientist by the benefits he or she brings to science and society; by this measure Archer Martin was outstanding, and rightfully his contribution was recognized with a Nobel Prize. Scientific instruments and instrumental methods now come almost entirely from commercial sources and we take them for granted and often have little idea how they work. Archer Martin was of a different time when scientists would often devise their own new instruments, which usually they fully understood, and then they would use them to explore the world. The chromatographic methods and instruments Martin devised were at least as crucial in the genesis and development of molecular biology as were those from X-ray crystallography. Liquid partition chromatography, especially in its two-dimensional paper form, revealed the amino acid composition of proteins and the nucleic acid composition of DNA and RNA with a rapid and elegant facility. Gas chromatography (GC) enabled the accurate and rapid analysis of lips, which previously had been painfully slow and little more than a greasy sticky confusion of beaker chemistry. Martin's instruments enabled progress in the sciences ranging from geophysics to biology , and without im we might have waited decades before another equivalent genius appeared. More than this, the environmental awareness that Rachel Carson gave us would never had solidified as it did without the evidence of global change measured by GC. This instrumental method provided accurate evidence about the ubiquity of pesticides and pollutants and later made us aware of the growing accumulation in the atmosphere of chlorinated fluorocarbons, nitrous oxide and other ozone-depleting chemicals. If all this were not enough to glorify Martin's partition chromatography, there is the undoubted fact that its simplicity, economy and exquisite resolving power transformed the chemical industry and made possible so many of the conveniences we now take for granted.
Biogr Mem Fellows R Soc 2004
PMID:Archer John Porter Martin CBE 1 March 1910 - 28 July 2002. 1575 73

K. J. Malmberg, J. Holden, and R. M. Shiffrin (2004) reported more false alarms for low- than high-frequency words when the foils were similar to the targets. According to the source of activation confusion (SAC) model of memory, that pattern is based on recollection of an underspecified episodic trace rather than the error-prone familiarity process. The authors tested the SAC account by varying whether participants were warned about the nature of similar foils and whether the recognition test required the discrimination. More false alarms for low-frequency similar items occurred only when participants were not warned at study about the subtle features to be discriminated later. The differential false-alarm rate by word frequency corresponded to the pattern of remember responses obtained when the test instructions did not ask for a subtle discrimination, supporting the SAC account that reversed false-alarm rates to similar foils are based on the recollection process.
J Exp Psychol Learn Mem Cogn 2005 May
PMID:The effects of word frequency and similarity on recognition judgments: the role of recollection. 1591 Jan 38

Diverse outcomes, both facilitative and disruptive, have been reported for the effect of interpolated item recognition tests on the acquisition of a cognitive skill. We collected data from a repeated set of 12 artificial arithmetic problems, soliciting compute/retrieve strategy reports after every trial. In one condition, a recognition test was administered after every three blocks of training. Recognition testing was found to depress retrieve frequencies in both younger and older adults, particularly for newly acquired items. Pairing training items with similar recognition foils mitigated these effects. This pattern of results could be explained by assuming that the participants based compute/retrieve decisions on item familiarity or frequency, tracked across both skill trials and recognition trials, and on a threshold influenced by source confusion. Variations in the threshold parameter could lead to depressed reports of item retrieval (our findings) or to elevated retrieval decisions, as has been shown in some other studies.
Mem Cognit 2006 Apr
PMID:Determinants of retrieval solutions during cognitive skill training: source confusions. 1693 63

Olfactory learning assays in Drosophila have revealed that distinct brain structures known as mushroom bodies (MBs) are critical for the associative learning and memory of olfactory stimuli. However, the precise roles of the different neurons comprising the MBs are still under debate. The confusion surrounding the roles of the different neurons may be due, in part, to the use of different odors as conditioned stimuli in previous studies. We investigated the requirements for the different MB neurons, specifically the alpha/beta versus the gamma neurons, and whether olfactory learning is supported by different subsets of MB neurons irrespective of the odors used as conditioned stimuli. We expressed the rutabaga (rut)-encoded adenylyl cyclase in either the gamma or alpha/beta neurons and examined the effects on restoring olfactory associative learning and memory of rut mutant flies. We also expressed a temperature-sensitive shibire (shi) transgene in these neuron sets and examined the effects of disrupting synaptic vesicle recycling on Drosophila olfactory learning. Our results indicate that although we did not detect odor-pair-specific learning using GAL4 drivers that primarily express in gamma neurons, expression of the transgenes in a subset of alpha/beta neurons resulted in both odor-pair-specific rescue of the rut defect as well as odor-pair-specific disruption of learning using shi(ts1).
Learn Mem
PMID:Roles for Drosophila mushroom body neurons in olfactory learning and memory. 1698 May 42

Within the context of an interactive anagram-solving task, the present studies tested predictions about the role of cognitive anticipation in both source and item memory. After working in pairs to solve anagram problems, participants were surprised by a source-monitoring test focused on the source of solutions (self vs. partner, Experiment 1) or a standard recognition test focused on the solutions themselves (Experiment 2). With the intention of affecting the opportunity to anticipate partners' solutions, two variables were manipulated: anagram difficulty (easy vs. hard) and the delaybetween the presentation of an anagram problem and theprompt tha t designated one member of each pair as the anagram solver. Consistent w i th predictions, asthe opportunity t oanticipate partners'solutions increased, there was a decrease in source accuracy suggesting increased confusion about whether the solution had been self- or partner-generated. Generation-effect failures were observed in item memory. However, these failures reflected increases in item memory for partners' responses rather than decreases in memory for self-generated ones. These studies suggest that when opportunities to anticipate partners' responses are available, self-generative activities may be associated with both self-and partner-generated items, influencing the expression of the generation effect.
Mem Cognit 2006 Oct
PMID:Anticipating partners' responses: examining item and source memory following interactive exchanges. 1726 77

Many models of immediate memory predict the presence or absence of various effects, but none have been tested to see whether they predict an appropriate distribution of effect sizes. The authors show that the feature model (J. S. Nairne, 1990) produces appropriate distributions of effect sizes for both the phonological confusion effect and the word-length effect. The model produces the appropriate number of reversals, when participants are more accurate with similar items or long items, and also correctly predicts that participants performing less well overall demonstrate smaller and less reliable phonological similarity and word-length effects and are more likely to show reversals. These patterns appear within the model without the need to assume a change in encoding or rehearsal strategy or the deployment of a different storage buffer. The implications of these results and the wider applicability of the distributionmodeling approach are discussed.
J Exp Psychol Learn Mem Cogn 2008 Jan
PMID:Modeling distributions of immediate memory effects: no strategies needed? 1819 64

Unconscious plagiarism occurs when people try to generate new ideas or when they try to recall their own ideas from among a set generated by a group. In this study, the factors that independently influence these two forms of plagiarism error were examined. Participants initially generated solutions to real-world problems in 2 domains of knowledge in collaboration with a confederate presented as an expert in 1 domain. Subsequently, the participant generated improvements to half of the ideas from each person. Participants returned 1 day later to recall either their own ideas or their partner's ideas and to complete a generate-new task. A double dissociation was observed. Generate-new plagiarism was driven by partner expertise but not by idea improvement, whereas recall plagiarism was driven by improvement but not expertise. This improvement effect on recall plagiarism was seen for the recall-own but not the recall-partner task, suggesting that the increase in recall-own plagiarism is due to mistaken idea ownership, not source confusion.
J Exp Psychol Learn Mem Cogn 2009 Jan
PMID:Source credibility and idea improvement have independent effects on unconscious plagiarism errors in recall and generate-new tasks. 1921 97

Eight experiments with the complex span paradigm are presented to investigate why concurrent processing disrupts short-term retention. Increasing the pace of the processing task led to worse recall, supporting the hypothesis that the processing task distracts attention from maintenance operations. Neither phonological nor semantic similarity between memory items and processing-task material impaired memory. In contrast, the degree of phonological overlap between memory items and processing-task material affected recall negatively, supporting feature overwriting as one source of interference in the complex span paradigm. When compared directly, phonological overlap impaired memory, but similarity had a beneficial effect. These findings rule out response competition or confusion as a mechanism of interference between storage and processing.
Mem Cognit 2009 Apr
PMID:Interference between storage and processing in working memory: Feature overwriting, not similarity-based competition. 1924 49

The more accurately people assess their comprehension, the more likely they are to engage in study behaviors that precisely target gaps in their learning. However, comprehension regulation involves more than knowing when to implement a new study strategy; it also involves deciding which strategy will most effectively resolve one's confusion. In two experiments, we explored how people's motivational orientations influence which study strategies they select to regulate their comprehension. In Experiment 1, people who were motivated to vigilantly protect against potential mistakes (i.e., prevention-focused individuals) were more likely to adopt a rereading strategy than people who were motivated to eagerly pursue new learning opportunities (i.e., promotion-focused individuals). In Experiment 2, this difference in strategy use emerged specifically in response to confusing sentences that had been inserted into the text. Furthermore, by using rereading strategies to resolve their confusion, prevention-focused individuals performed better than promotion-focused individuals on a comprehension test and a transfer task.
Mem Cognit 2009 Sep
PMID:Motivated comprehension regulation: vigilant versus eager metacognitive control. 1967 58


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