Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0009443 (
cold
)
92,137
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones.
Antivenin
is currently the only specific medicine for envenomation. However, it is restricted by
cold
storage, snakebite diagnosis, and high price. Snake venom phospholipase A
2
s (svPLA
2
s) are found in all kinds of venomous snake families (e.g., Viperidae, Elapidae, and Colubridae). Along with their catalytic activity, svPLA
2
s elicit a wide variety of pharmacological effects that play a pivotal role in envenomation damage. Hence, neutralization of the svPLA
2
s could weaken or inhibit toxic damage. Here we overviewed the latest knowledge on the distribution, pathophysiological effects, and inhibitors of svPLA
2
s to elucidate the potential for a novel, wide spectrum antivenom drug targeting svPLA
2
s.
...
PMID:Snake Venom PLA
2
, a Promising Target for Broad-Spectrum Antivenom Drug Development. 2931 52
