Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0009443 (cold)
 92,137 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cytostatics have no effect on antigen-antibody reactions in vitro. Immunosuppression by cytostatics is mainly based on the inhibition of immunocytes. Prednisolone inhibits RA-factors in the Waaler-Rose-test; the mechanism of this effect is not understood at the present time. Acetylsalicylic acid has no influence on the antigen-antibody reactions investigated. Nucleotides inhibit only ANA; the effect is probably based on a cross reaction with ANA. D-enicillamine inhibits RA-factors and other IgM-antibodies by splitting SS-bonds in macromolecules of immunoglobulins. Quinoline derivatives inhibit RA-factors, ANA, cold agglutinins and IgG-isoantibodies and autoantibodies to erythrocytes. Contrary to nucleotides, prednisolone and d-penicillamine, which also inhibit antigen-antibody reactions, chloroquine is splitting immune complexes; after the aplitting of the complexes the reactivity of antigens and antibodies is not impaired. The mechanism of action of chloroquine might be connected with physical and chemical processes of the antigen-antibody reaction. The reduction of the surface charge of human red cells is not related to the inhibition of antigen-antibody reactions by the substances investigated.
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PMID:[Effect on quinoline derivatives, nucleotides, D-penicillamine,cytostatic and antiphogistic drugs on the rheumatoid factors other immune antibodies]. 109 67

A 53-year-old male was diagnosed as having ataxic polyneuropathy associated with IgM-kappa monoclonal gammopathy in January 1988. Plasmapheresis and chemotherapy with chlorambucil and Melphalan-Prednisolone were effective for his neuropathy, but hemolytic anemia appeared in February 1989. The diagnosis of low-titer cold agglutinin disease (IgM-kappa) with anti-Pr2 specificity was made. Hemolytic anemia became refractory to high-dose corticosteroids, and fever, hepatosplenomegaly and severe pancytopenia appeared in January 1990. Bone marrow involvement of malignant lymphoma (mu, kappa) was found, and he died of pneumonia and gastrointestinal bleeding after the start of chemotherapy. Postmortem examination revealed a widespread infiltration of malignant lymphoma, diffuse, large cell (B-cell) type. Erythrophagocytic histiocytes also increased in bone marrow, liver, spleen and lymph nodes, as if there were hemophagocytic syndrome associated with lymphoma present. In addition to the high thermal amplitude of cold agglutinin in this case, the systemic activation of histiocytes induced by the development of malignant lymphoma may be responsible for progressive hemolysis and severe pancytopenia.
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PMID:[Anti-Pr2 cold agglutinin disease with polyneuropathy evolving to malignant lymphoma]. 133 64

An investigation was carried out into the release of chlorhexidine acetate, prednisolone sodium phosphate, and prednisolone alcohol from a cold cured acrylic denture base material. The drugs were added at 10% w/w with the powder phase of the material. Water, at the concentrations of 10%, 20%, and 30% of the monomer phase of the material was added to chlorhexidine-containing and chlorhexidine-free samples. Spectrophotometric and bioassay measurements of the release of chlorhexidine demonstrated protracted delivery to 140 days. The daily release rate was increased by the addition of water to the material and at 30% water incorporation the release was greater and increased up to 190 days. The release pattern of prednisolone sodium phosphate was similar to that of chlorhexidine without the addition of water. Prednisolone alcohol was released for a much shorter period and at lower levels. Scanning electron microscopic examination of the polished, etched, and fractured surfaces of the material demonstrated that chlorhexidine acetate and prednisolone sodium phosphate were incorporated into the interbead matrix areas of the material. The irregularities in the material increased with the addition of water. Prednisolone alcohol produced minimal changes in the specimens except after soaking in water for 140 days when numerous small defects could be seen in the matrix zones at high magnification. The use of materials such as water to increase porosity appears a simple method of improving the release pattern of drugs from acrylic. However, the strength of the resulting material would require support from an existing intraoral prosthesis or appliance.
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PMID:In vitro studies into the release of chlorhexidine acetate, prednisolone sodium phosphate, and prednisolone alcohol from cold cure denture base acrylic. 706 33

A 64-year-old women presented with a dry cough. The common cold was diagnosed and she was given medication, but the symptom did not resolve. She came to our hospital, and multiple patchy shadows were seen on a chest X-ray film. Bronchoalveolar lavage fluid contained an abnormally high percentage of eosinophils. Microscopic examination of transbronchial lung biopsy specimens showed infiltration of eosinophils into the alveoli and alveolar septa. Chronic eosinophilic pneumonia was diagnosed. Analysis of bone marrow cells showed high percentages of mature eosinophilic cells, and blood serum had a high concentration of eosinophil cationic protein. An inhalation challenge test with methacholine revealed bronchial hypersensitivity and hyperresponsiveness. Prednisolone (30 mg/day) was given and the symptoms resolved. After steroid treatment, the patient was asymptomatic, although airway hyperresponsiveness remained. The concentration of eosinophil cationic protein in serum and the results of the methacholine inhalation test reflected the degree of chronic eosinophilic pneumonia, and the production of eosinophils in bone marrow was suppressed by steroid medication.
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PMID:[Chronic eosinophilic pneumonia involving eosinophil cationic protein and bone marrow cells]. 895 6

A 68-year-old woman first noticed Raynaud's phenomenon at the age of 35, and she was diagnosed as having systemic sclerosis (SSc) because of cutaneous calcinosis, sclerodactyly, telangiectasia, sausage-like finger, digital pitting scar in 1971. In October, 1994, she was suffered from cold sensation in her right foot, and on November 2 she noticed the painful ulcers on the right toe, which progressed to be gangrenous. Every antiplatelet or thrombolytic agents including PGE1, argatroban, sarpogrelate hydrochloride and urokinase were unsuccessful. Angiograms revealed marked narrowing of bilateral anterior and posterior tibial and peroneal arteries. Prednisolone 30 mg/day was started, which resulted in successful response within 10 days. Large vessel involvement in SSc patients has been reported to be rare, and its treatment remains to be established. We believe our case help understanding the pathophysiology of such rare manifestation in SSc.
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PMID:[Successful treatment of toe gangrene with moderate-dose steroid therapy in a patient with systemic sclerosis (CREST syndrome)]. 925 35

We report a case of drug-induced pneumonitis caused by acetaminophen taken for headache. The patient was a 49-year-old woman who had been taking a common cold drug (Benza BlockSP) containing acetaminophen and an anti-gastritis drug for headache. Seven days after she began taking acetaminophen, fever, dry cough, and dyspnea developed. The patient was admitted to our hospital on December 6,1996. Chest X-ray films and computed tomography scans revealed ground-glass and reticulonodular opacities. All chemotherapy was discontinued under a presumptive diagnosis of drug-induced pneumonitis. Transbronchial lung biopsy specimens revealed infiltration of lymphocytes and eosinophils into the alveolar walls and interstitum, with granulomotous lesions and macrophages in the alveolar spaces. The patient's chest X-ray findings improved and her symptoms subsided after the medications were stopped. However, she was given oral prednisolone (30 mg/day) because shadows were still evident on chest X-ray films. Prednisolone was effective in removing those shadows. A lymphocyte stimulation test was positive for acetaminophen. Based on the above findings, acetaminophen-induced pneumonitis was diagnosed. To our knowledge, acetaminophen-induced pneumonitis is rare. However, when drug-induced pneumonitis is suspended, common cold drugs containing acetaminophen should be kept in mind.
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PMID:[Acetaminophen-induced pneumonitis]. 991 83

A 38-year-old woman was admitted to the Iiyama Red Cross Hospital with a non-productive cough. She had been working with Strophariaceae cultures for 4 years, and in January 1999 a cough had developed. On admission, hypoxemia was noted. The serum level of lactate dehydrogenase was slightly elevated. Chest radiography and CT scanning showed diffuse ground glass opacity and small centrilobular nodules in both lower lobes. In the bronchoalveolar lavage fluid, the total cell count was normal, the CD4/CD8 ratio was reduced, and the lymphocyte fraction was very high. A transbronchial lung biopsy revealed alveolitis with lymphocytic infiltration and organizing changes like Masson bodies. The lymphocyte stimulation test was positive for Strophariaceae. Hypersensitivity pneumonitis caused by Strophariaceae was diagnosed. Prednisolone was administered because of persistent symptoms and prolonged abnormal chest radiography findings. These abnormalities disappeared 2 weeks after prednisolone treatment was initiated. There is one previous report of hypersensitivity pneumonitis caused by Strophariaceae. The symptoms are coughing and sputum production as in the common cold. The occupational history must be carefully considered in making a diagnosis.
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PMID:[A case of hypersensitivity pneumonitis caused by Strophariaceae]. 1101 68

A case is reported of lymphoplasmacytoid lymphoma (LPL) associated with a monoclonal immunoglobulin (Ig) M and cold agglutinin disease (CAD) that was successfully treated with rituximab. A 52-yr-old male was admitted with a direct antiglobulin test positive haemolytic anaemia and thrombocytopenia associated with monoclonal IgM. Bone marrow examinations disclosed the marked infiltration of medium-sized lymphoma cells with plasmacytoid differentiation that indicated non-Hodgkin's lymphoma of B-cell origin (LPL). Prednisolone and combination chemotherapy were temporarily effective for both anaemia and thrombocytopenia, although these strategies became refractory and bone marrow lymphoplasmacytosis persisted. CAD ameliorated, and the serum level of IgM decreased in association with the disappearance of lymphoma cells and clonal rearrangement of the Ig heavy chains in the bone marrow after treatment with rituximab. Rituximab played a significant role in the treatment of refractory CAD associated with LPL.
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PMID:Beneficial effects of rituximab on primary cold agglutinin disease refractory to conventional therapy. 1207 42

Lymphocytic hypophysitis is a rare inflammatory disease of the pituitary gland that is being increasingly recognized as a cause of hypopituitarism. This condition may be due to an autoimmune pituitary destruction which usually occurs in young women during pregnancy or in the immediate postpartum period. We describe a case of cystic pituitary mass in a thirty-eight year-old woman presenting with nausea, vomiting, cold intolerance, blurring of vision and the presence of disagreeable odors for a one-month period. She had secondary amenorrhea and galactorrhea for three months. Combined anterior pituitary stimulation test confirmed the diagnosis of hypopituitarism. Magnetic resonance imaging scan with enhancement showed a huge cystic sellar mass with suprasellar extension and thickening of the pituitary stalk. Transsphenoidal exploration was performed with preoperative diagnosis of pituitary macroadenoma with cystic necrosis. Histological examination revealed lymphocytic hypophysitis characteristic of diffuse, dense lymphocytes and plasma cells infiltration with surrounding interstitial reactive fibrosis. Postoperatively, the patient's olfactory function returned to normal but combined anterior pituitary stimulation test showed persistence of hypopituitarism with mild hyperprolactinemia. Prednisolone, thyroxine and estrogen replacements were started and clinical symptoms were much improved. In summary, we report an extremely rare case of a woman with cystic lymphocytic hypophysitis with cacosmia and hypopituitarism, confirmed by histological examination.
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PMID:A case of cystic lymphocytic hypophysitis with cacosmia and hypopituitarism. 1525 85

A 67-year-old man, treated for years for hypertension, presented with a persistent dry cough and dyspnea 10 days after the administration of drugs including Sho-seiryu-to against the common cold. Chest X-ray and CT scans revealed diffuse reticular shadows in both lung fields. Under a suspected diagnosis of drug-induced pneumonia or a complex of bacterial and interstitial pneumonia, Sho-seiryu-to was discontinued and antibiotics started. After several days, chest X-ray reticular shadows developed and hypoxia worsened. Subsequently the patient received Prednisolone. Two days later his symptoms and findings markedly improved. Drug lymphocyte stimulation tests for Sho-seiryu-to using peripheral lymphocyte were positive and other drugs were negative. Chest CT showed the reversed halo sign in right middle zone, which was relatively specific to the cryptogenic organizing pneumonia. On the basis of clinical history and these findings, we diagnosed a drug-induced interstitial pneumonia caused by the herbal medicine Sho-seiryu-to. To our knowledge, this is the first case of Sho-seiryu-to induced interstitial pneumonia to be reported.
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PMID:[A case where herbal medicine sho-seiryu-to induced interstitial pneumonitis]. 1570 49


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