Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0009443 (cold)
 92,137 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 27-year-old man, two 54-year old men and a 64-year-old woman presented with aspecific symptoms: acute pain and tingling in the shoulders plus paraplegia; exertional dyspnoea and tingling in both feet for the past week; increasing shortness of breath and cold, pale legs and feet for the past week; acute retrosternal pain, incontinence and paraparesis. The cause was dissection of the ascending aorta (type A). Following the operation, the legs were amputated because of ischaemia. The 27-year-old man and one of the 54-year-old men died; the other two patients made a satisfactory recovery. Acute type-A aortic dissection is a life-threatening disease that must be recognised early because it is an absolute indication for emergency surgery. The initial manifestation of type-A dissection may be very aspecific. Post-operative lower limb ischaemia, as the first symptom of this disease, is rare and usually disappears after surgery for type-A dissection. In some cases, however, ischaemia persists and alters the post-operative course dramatically.
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PMID:[Ischemia of the lower limbs as a symptom of acute dissection of the ascending aorta]. 1456 Jun 84

In postherpetic neuralgia, as in all types of neuropathic pain, it is generally accepted that outcome can be affected early management with specific analgesics. However, when one looks at the diagnostic criteria appearing in the literature, there is no consensus. Authors use the notion of latency to situate the onset of postherpetic neuralgia within the continuum of herpetic pain. Depending on the Author, this latency period ranges from one to six Months after the skin eruption. This latency is poorly compatible with early intervention and not well-adapted to everyday practice. With the aim of finding ways to improve the management of pain, the Neuropathic Pain Expert Group agreed upon a new definition. Postherpetic neuralgia is pain in the involved site after the skin eruption has healed and which displays the features of neuropathic pain. This definition, which does away with the latency criterion, is based on the identification of one or more clinical features of neuropathic pain in a situation of treatment failure, namely: presence of chronic unsolicited pain (burning, tightness, pressure) and/or paroxysmal pain (tingling, stabbing pain) and/or mechanical hyperalgia/allodynia (to friction or pressure) and/or temperature sensitivity (to heat and/or cold). Such pain occurs in circumscribed neurologic zones in which a sensory deficit can be demonstrated and is usually associated with dysesthesia and/or paresthesia.
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PMID:[Thoughts on the definition of postherpetic pain: the time criterion adds nothing]. 1524 65

Sensory symptoms are crucial for the diagnosis of carpal tunnel syndrome (CTS). We have studied the spectrum of sensory symptoms in 67 cases of neurophysiologically confirmed CTS in Singapore and investigated the correlation of semi-quantitative clinical ('Historical-Objective') and neurophysiological ('Bland') scales. The range of sensory symptoms was large. The more frequent use of the terms 'woodenness' and 'aching' rather than 'pins and needles' suggests racial and cultural differences in symptom expression, or recognition of previously ignored descriptors. 'Numbness' (97%) was the most common descriptive symptom, followed by 'tingling' (81%), 'tightness' (60%), 'aching' (45%), 'woodenness' (39%) and 'pins and needles' (33%). Less common were 'deadness' (27%), prickling (24%), and cramp-like pain (18%). Uncommon sensations included 'jabbing' (10%), 'shooting pain' (10%), 'stabbing' (9%), 'tight-band like pressure' (9%), 'cold' (8%), 'crushing' (6%) and 'burning' (6%). The semi-quantitative clinical and neurophysiological scales correlated well (Pearson 0.645, P<0.001).
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PMID:Symptoms associated with electrophysiologically verified carpal tunnel syndrome in Asian patients. 1648 35

Clinicians claim that patients habituate to cold-induced pain during cryokinetic treatments, but this has not heretofore been tested. We treated the right ankle of 38 subjects with a simulated cryokinetic treatment daily for 8 days using either 1 degrees or 5 degrees C water. On days 9 and 10, the right ankle was treated with the opposite temperature and the opposite ankle (left) was treated with the habituation temperature. Cold-induced pain was recorded five times each day (after each ice immersion bout) using Borg's Perceived Pain Scale and the McGill Pain Questionnaire. There was a sharp decrease in pain from days 1 through 5, but no difference between days 5 through 8. Pain during bout one was significantly greater than the following four bouts for all days except day 1. Location of pain changed between days but not between bouts. The instep was the most frequent location of pain for the first 3 days. The choice of "no specific location" increased steadily from day 2 to 8. The number of descriptor terms chosen on the McGill Pain Questionnaire decreased from day 1 to day 8. Exceptions to this were the terms cool, cold, freezing, and numb. Common terms chosen on days 1 through 3 were throbbing, sharp, burning, tingling, hurting, and nagging. On days 9 and 10, pain in the opposite (left) limb was greater than pain at the end of right limb habituation, but similar to day 1 of habituation. Right limb immersion with a lower temperature resulted in greater pain than that perceived on day 8. Daily repeated cryokinetic treatments are sufficient to produce habituation to cold-induced pain. Habituation was specific to the limb treated and temperature of habituation; thus, we conclude it is primarily physiological with some psychological influence. Athletic trainers are justified in telling patients who are undergoing ice water immersion that the cold pain will diminish with repeated applications.
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PMID:Habituation to cold-pain during repeated cryokinetic sessions. 1655 65

Transcutaneous electrical nerve stimulation (TENS) is used to relieve acute and chronic pain. TENS electrodes are applied at the site of pain or in segments related to the pain, although there is limited research to support either approach. This study investigated the effects of unilateral TENS on mechanical and thermal thresholds at ipsilateral and contralateral sites in healthy human participants. Sensory perception thresholds were measured on the ipsilateral and contralateral thenar eminence of 16 volunteers for von Frey filaments, sharpness, warm, cold and heat pain. TENS was administered over the right median nerve for 10 min at 100 pulses per second (pps) and an intensity which elicited mild tingling in the hand. During TENS, ipsilateral threshold was greater than contralateral threshold for all sensory modalities, although differences were less marked for thermal stimuli. TENS effects had disappeared 30 min after TENS had been switched off although there was a tendency for thermal thresholds to remain elevated. We conclude that during stimulation, TENS elevates somatosensory thresholds within the distribution of the stimulated nerve. The rapid and short-lived ipsilateral effect is consistent with findings from animal studies and suggests a central segmental mechanism.
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PMID:The effects of unilateral transcutaneous electrical nerve stimulation of the median nerve on bilateral somatosensory thresholds. 1693 10

This report describes a case of acute renal failure due to rhabdomyolysis that developed after prolonged exposure to cold. A 47-year-old man visited a mountain during winter wearing only casual clothes and became lost at temperatures below freezing for 8 hours. Upon admission, the patient complained of a tingling sensation and numbness in the both upper and lower extremities with anuria. The serum blood urea nitrogen, creatinine, creatinine kinase, and myoglobin levels were elevated. Bone scintigraphy on the second day revealed increased activity in the superficial muscle groups in the abdomen, back, buttock, thighs, legs, and arms, which was compatible with rhabdomyolysis.
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PMID:Cold exposure-induced rhabdomyolysis demonstrated by bone scintigraphy. 1843 Nov 54

Ciguatera fish poisoning (CFP) is a distinctive type of foodborne disease that results from eating predatory ocean fish contaminated with ciguatoxins. As many as 50,000 cases are reported worldwide annually, and the condition is endemic in tropical and subtropical regions of the Pacific basin, Indian Ocean, and Caribbean. In the United States, 5--70 cases per 10,000 persons are estimated to occur yearly in ciguatera-endemic states and territories. CFP can cause gastrointestinal symptoms (nausea, vomiting, abdominal cramps, or diarrhea) within a few hours of eating contaminated fish. Neurologic symptoms, with or without gastrointestinal disturbance, can include fatigue, muscle pain, itching, tingling, and (most characteristically) reversal of hot and cold sensation. This report describes a cluster of nine cases of CFP that occurred in North Carolina in June 2007. Among the nine patients, six experienced reversal of hot and cold sensations, five had neurologic symptoms only, and overall symptoms persisted for more than 6 months in three patients. Among seven patients who were sexually active, six patients also complained of painful intercourse. This report highlights the potential risks of eating contaminated ocean fish. Local and state health departments can train emergency and urgent care physicians in the recognition of CFP and make them aware that symptoms can persist for months to years.
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PMID:Cluster of ciguatera fish poisoning--North Carolina, 2007. 1932 30

Three sensory systems, olfaction, taste, and somatosensation, are dedicated to the detection of chemicals in the environment. Trigeminal somatosensory neurons enable us to detect a wide range of environmental stimuli, including pressure, temperature, and chemical irritants, within the oral and nasal mucosa. Natural plant-derived irritants have served as powerful pharmacological tools for identifying receptors underlying somatosensation. This is illustrated by the use of capsaicin, menthol, and wasabi to identify the heat-sensitive ion channel TRPV1, the cold-sensitive ion channel TRPM8, and the irritant receptor TRPA1, respectively. In addition to TRP channels, members of the two-pore potassium channel family have also been implicated in trigeminal chemosensation. KCNK18 was recently identified as a target for hydroxy-alpha-sanshool, the tingling and numbing compound produced in Schezuan peppers and other members of the Xanthoxylum genus. The role of these channels in trigeminal thermosensation and pain will be discussed.
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PMID:Molecular and cellular mechanisms of trigeminal chemosensation. 1968 35

Previous studies investigated the neural and molecular underpinnings of the tingle sensation evoked by sanshool and other natural or synthetic alkylamides. Currently, we sought to characterize the psychophysical properties associated with administration of these compounds. Like other chemesthetic stimuli, the synthetic tingle analog isobutylalkylamide (IBA) evoked a sensation that was temporally dynamic. Repeated IBA application at short (30 sec) interstimulus intervals (ISI) resulted in a tingle sensation that increased across trials. Application at longer ISIs (approximately 30 min) resulted in a sensation of decreased intensity consistent with self-desensitization. Prior treatment with the TRPV1 or TRPA1 agonists, capsaicin and mustard oil did not cross-desensitize the tingle sensation evoked by IBA suggesting that neither TRPV1 nor TRPA1 participate in the transduction mechanism sub-serving tingle. When evaluated over 30-min time period, lingual IBA evoked a sensation that was described initially as tingling and pungent but after approximately 15 min, as a cooling sensation. Further, we found that the sensation evoked by lingual IBA was potentiated by simultaneous application of cold (0 degrees C) and cool (21 degrees C) thermal stimuli but was unaffected by warm (33 degrees C) and hot (41 degrees C) temperatures. Finally, to test the hypothesis that the tingling sensation is subserved by the activation of mechanosensitve fibers, we evaluated lingual tactile thresholds in the presence and absence of lingual IBA. The presence of IBA significantly raised lingual tactile thresholds, whereas capsaicin did not, identifying a role for mechanosensitive fibers in conveying the tingle sensation evoked by sanshool-like compounds. Collectively, these results show that lingual alkylamide evokes a complex sensation that is temporally dynamic and consistent with in vitro and in vivo experiments suggesting these compounds activate mechanosensitve neurons via blockade of KCNK two-pore potassium channels to induce the novel tingling sensation.
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PMID:Psychophysical evaluation of a sanshool derivative (alkylamide) and the elucidation of mechanisms subserving tingle. 2020 90

Neuropathic side effects are commonly reported in patients receiving oxaliplatin, but little is known about the characteristics of peripheral neuropathy in this patient population. The purpose of this descriptive study was to explore the prevalence of neuropathic symptoms in patients with colorectal cancer receiving oxaliplatin as well as to explore symptom severity, distress, frequency, and neuropathic interference with activities. Thirty-three patients receiving oxaliplatin at two outpatient facilities completed the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool. Data were analyzed using descriptive statistics. Cold sensitivity, tingling in the hands, and numbness in the hands were the most prevalent neuropathic symptoms, and cold sensitivity, nerve pain, and trouble with balance were the most severe symptoms. Trouble with balance, muscle or joint aches, and neuropathic pain were the most distressing symptoms, and numbness in the fingers and hands and in the toes and feet were the most frequent symptoms. Patients reported that neuropathic symptoms interfered with numerous activities. Oncology nurses can use this information to help educate patients and families about potential side effects of oxaliplatin and to coordinate the care of patients with peripheral neuropathy using a symptom-focused, multidisciplinary approach.
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PMID:Peripheral neuropathy in patients with colorectal cancer receiving oxaliplatin. 2144 85


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