Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0009443 (cold)
 92,137 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Circulatory regulation in response to postural changes follows mechanical rules, whereby the shifts in volume in the various organs of the body play an essential role. The change from the horizontal to the vertical position is accompanied by a decrease in pressure above the hydrostatic neutral point, i.e. in the cephalic vessels, whereas the capacious vessels in the caudal region are dilated and the venous return becomes sluggish. As a consequence of the different time courses followed by the various circulatory parameters in the wake of counter-regulatory measures, a distinction can be made between an early orthostatic instant regulatory response and a late orthostatic response. Prominent clinical features do not necessarily always consist of non-systemic dizziness, tinnitus, pallor cold sweat and, finally, orthostatic collapse, but general subjective symptoms such as deafness and tingling of the extremities, a chilly sensation and cardiac symptoms may frequently predominante. In the case of development of an autonomic neurotic symptom complex, psychoautonomic symptoms such as general sleep disturbance are observed. Apart from investigations carried out on a surgical tilting table in general practice, other procedures such as the Valsalva manoeuvre, the squatting test and, in most cases, the erect test are performed. Broadly speaking four different reaction types can be distinguished amongst cases of postural hypotension. Drugs with different therapeutic actions are selectively administered according to the pathophysiological characteristics of the individual patient and the sympathetic adrenal counter-regulatory response. Medico-mechanical measures and physical training should not be neglected.
 ...
PMID:[Postural hypotension: pathophysiology and clinical features (author's transl)]. 1 41

The present study was designed to examine the prevalence and characteristics of painful and paresthetic sensations in a group of patients with healed burns. Adult patients who had been hospitalized for burn injuries during a 7-yr period were contacted and given a structured interview that included a series of questions about their present condition. Patients' medical charts were reviewed to obtain relevant demographic and medical information. The results show that abnormal sensations in healed burns are frequently reported as long as several years after the injury. Of 104 patients interviewed 1 yr or more after a burn injury, 82% reported paresthetic sensations such as tingling, stiffness, cold sensations, and numbness; and 35% complained of pain in the scarred tissue. The prevalence of these sensations was not related to age, sex, or etiology of the burns, but was associated with burn size and skin grafting. The theoretical and clinical implications of these results are discussed with particular emphasis on the need to pursue research on the long-term adverse effects of burn injuries.
 ...
PMID:Pain and paresthesia in patients with healed burns: an exploratory study. 194 Apr 89

The degree of Raynaud's phenomenon due to the use of vibrating tools is difficult to assess because of the episodic nature of the attacks and the paucity of vascular and neurologic signs between attacks. Ninety-two loggers, miners and other workers using vibrating tools and experiencing Raynaud's phenomenon were examined at the Vancouver General Hospital between 1982 and 1985. Details of history, symptoms and occupation were obtained. The majority of workers had loss of sensation in their hands to pinprick, and the extent of this correlated closely with the severity of symptoms, a correlation not previously described. In 16 subjects the loss of sensation was proximal to the level of symptoms, in 50 at the same level and in 23 distal. In three the correlation was unknown. The severity of the vibration white finger syndrome was assessed using the classification of Taylor. Four workers were placed in stage 1 (occasional blanching of fingertips, with or without tingling or numbness), 30 in stage 2 (blanching of one or more fingers with numbness in cold weather), 36 in stage 3 (frequent finger blanching affecting most digits) and 22 in stage 4 (as stage 3 but symptoms so severe that manual work is difficult and vibrating tools cannot be used). The correlation of symptoms with loss of sensation to pinprick was useful in assessing the severity of the syndrome and in the classifying of claimants for Workers' Compensation Boards.
 ...
PMID:Assessment of vibration white finger syndrome. 375 54

This study was performed on 187 patients with vibration syndrome treated and followed for more than five years in 10 hospitals in Japan. The subjects had disturbances of circulation and sensation in their fingers and of joint movements in their upper extremities. Most of the patients received treatment combining physical and drug therapy. Data were analyzed to determine the effective treatment period for improving the disturbances. The blanching attack Raynaud's phenomenon) and abnormal cold and tingling sensations in the fingers were significantly improved only during the first two years of treatment. A temperature test and plethysmography suggested improvement in finger circulation only during the first three years and one year of treatment, respectively. Spontaneous numbness and pain in the fingers did not improve. The pin-prick and vibratory sensations showed recovery only during the first three and two years of treatment, respectively. Lowered conduction velocities of the ulnar and median nerves improved only during the first year. Limited movements in the wrist and elbow joints did not improve at all despite long-term treatment. Similar results were seen in an overall evaluation of the data. It was concluded that there is a limitation in the treatment of disturbances related to the vibration syndrome.
 ...
PMID:Follow-up study of patients with vibration syndrome in Japan. 377 15

The reliability and validity of two tests (cold water and reactive hyperaemia) designed to confirm a patient's history of vibration induced white finger were studied. The cold water test is a measure of digital rewarming after hand immersion in cold water. Reactive hyperaemia consists of measuring digital rewarming after cold water immersion plus temporary ischaemia imposed on the hand. For ten weeks, ten healthy male volunteers were submitted once a week to both tests to study their reliability. The results showed a strong inter and intraindividual scattering. The mean value for the whole group, however, did not differ significantly from one week to the next. Fifty two subjects exposed to hand/arm vibration were submitted to both tests to estimate their validity. They were classified, according to their medical history, into three groups: A = no symptoms, B = tingling or numbess, or both, C = Raynaud's phenomenon. Both tests agreed with the clinical staging. For reactive hyperaemia, however, the differences between the groups were statistically significant only when the test was performed at 10 degrees C. These tests are more useful to study a group than an individual case. Time has no significant effect on the mean result of a group.
 ...
PMID:Assessment of vibration induced white finger: reliability and validity of two tests. 396 78

Long-term use of hand-held vibratory tools has been implicated in the development of a clinical condition known under several names including occupational Raynaud's phenomenon, vibration-induced white finger (VWF) disease, and "dead" or "wax" finger. The syndrome is characterized in its early stages by tingling, numbness, or blanching of the finger tips provoked usually by exposure to cold temperatures; later these symptoms may extend to the base of all of the digits on both hands. As vibration exposure continues, the attacks become more frequent and cause manual impairment and social disability. This complex of VWF and associated arterial and related complications is now termed vibration syndrome (VS). Although epidemiologic studies indicate that large percentages of the population of workers at greatest risk are affected, the acceptance of VS as an industrial disease is only recent. This paper reviews some of the salient features of VS from the point of view of the dermatologist, since he may be the first health professional to see patients with this syndrome. Terminology, risk factors, preventative measures, therapy, and occupational guidelines are discussed.
 ...
PMID:Vibration syndrome in industry: dermatological viewpoint. 407 41

An approach to the management of the climacteric and postmenopausal patient is outlined. Menopause refers to the time at which menstruation ceases; climacteric, the period of transition. Neither is pathological. After the functional life of the ovary terminates when the supply of primary oocytes is exhausted, the feedback mechanism with FSH is disrupted leading to high blood and urinary levels of FSH. Estrogen often continues to be produced for about 10 years postmenopausally. Hormone therapy is indicated to treat vasomotor instability, such as hot flashes, numbness and tingling, vertigo, cold hands and feet, palpitations and headache, dysfunctional uterine bleeding, and senile vaginitis. The psychological changes often noted are functional and not due to estrogen withdrawal. There is currently no proof of the efficacy of long term estrogen replacement as a means of preventing heart diseases or osteoporosis.
 ...
PMID:Management of the climacteric and postmenopausal woman. 503 99

The clinical appearance of foramen magnum tumor is protean and, even at the stage when serious neurological deficits are present, the lesions are often misdiagnosed as another disease, especially cervical spondylosis and multiple sclerosis, and patients may undergo improper concervative or even surgical treatments. The best guarantee against misdiagnosis, we believed, was to establish a definition of "Foramen Magnum Syndrome" to facilitate the recollection of its peculiar clinical findings. "Foramen Magnum Syndrome" is composed of: 1. Cape distribution of sensory loss; 2. Atrophy of the intrinsic muscles of the hands; 3. Neck or suboccipital pain; 4. Dysesthesia of the hands (numbness, tingling, and cold sensation); 5. Eleventh cranial nerve palsy; 6. Stereoanesthesia. (Remember the mnemonic CANDES or DESCAN) Among these, cape distribution of sensory loss, eleventh cranial nerve palsy and cold dysesthesia (not numbness or tingling sensation) are of great importance for topological diagnosis. We also pointed out the similarities between the clinical picture of syringomyelia and that of the advanced stage of foramen magnum tumor. The syringomyelic syndrome, often seen in Arnold-Chiari malformation and basilar impression, has been attributed to the concurrent syrinx of cervical cord. But the clinical analysis of foramen magnum tumors showed that this is not always true and that compressive lesions at the foramen magnum alone can cause syringomyelic syndrome.
 ...
PMID:[Proposal for the definition of "foramen magnum syndrome"--foramen magnum tumor and abnormalities]. 665 78

Thirty-two patients with primary hypertension were studied in a double-blind cross-over comparison between the cardioselective beta 1-blocking agent atenolol and the combined alpha- and beta-blocking agent labetalol. The doses used were atenolol 50--150 mg twice daily and labetalol 200--600 mg twice daily. Both drugs effectively reduced blood pressure and heart rate. Dose increments every second week resulted in a higher proportion of patients with normal blood pressure (les than or equal to 150/90 mm Hg) with both drugs. Labetalol was somewhat more effective in lowering upright blood pressure while atenolol caused a more pronounced heart-rate reduction. Both agents decreased plasma renin activity and urinary aldosterone excretion. Scalp tingling on labetalol (2 patients) and cold fingers with atenolol (1 patient) caused withdrawal of the drugs. Cold fingers were reported in another four patients during treatment with atenolol and in one when on labetalol. Tiredness and postural symptoms were more common during intake of labetalol.
 ...
PMID:Antihypertensive and metabolic effects of increasing doses of atenolol and labetalol. A comparative study in primary hypertension. 676 Jun 79

This study identified preparatory information appropriate for patients undergoing myelogram. Twenty-eight patients (16 lumbar and 12 cervical) described the sensations they experienced as they were having a myelogram. Sensations reported by 40% or more of the participants having both kinds of myelograms included hard, cold examining table; wet and cold cleansing of site; stick with injection of local anesthetic; sharp stick with spinal needle insertion; and burning (cervical) or sharp, tingling (lumbar) with contrast medium injection. These sensations, linked with the temporal elements of the procedure, yield a preparatory information intervention appropriate for those scheduled for myelogram. When preparatory information is used for the same myelogram procedure as described in this study, patients should experience reduced anxiety before and during the procedure.
 ...
PMID:Preparatory information for myelogram. 756 Dec 65


1 2 3 4 5 6 Next >>