Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0009443 (cold)
 92,137 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cold hemagglutinin disease, a form of autoimmune hemolytic anemia caused by cold-acting erythrocyte autoantibodies, was diagnosed in a dog. Cold-acting antibodies differ from warm-acting antibodies in several ways, including temperature-dependent reactivity below 32 C. The autoantibody in this case (immunoglobulin M) was in the serum in higher than normal concentrations and was reactive at temperatures approaching freezing. The course of the disease was chronic and was characterized by cyanosis and necrosis of the body extremities. Immunosuppressive therapy with corticosteroids was successful in alleviating the clinical signs and reducing the autoantibody activity in the dog. The cause of this disorder was not determined.
 ...
PMID:Cold hemagglutinin disease in a dog. 84 80

Development of the Coombs test has led to rapid progress in the recognition of various autoimmune hemolytic anemias. Cold agglutinin disease, a relatively rare disorder, occurs in idiopathic and secondary forms, the latter often in association with diseases that alter the immune status. The higher the titer of cold agglutinin, the greater is the thermal range of its activity. One of the characteristic clinical manifestations of the disease is striking cyanosis in acral areas on exposure to cold, which abates quickly on warming. This parallels the accelerated hemolysis at cold temperatures, which is reversible as heat is applied. In some patients, however, the disease is covert and is discovered only incidentally. The report of such a case is included.
 ...
PMID:Cold agglutinin disease. 98 Oct 89

In approaching a patient suspected of peripheral vascular disease the following signs and symptoms are of key importance (16): 1) Pain in the extremity which is induced by exercise and relieved by rest; pain which is influenced by posture is localized to one digit, is unilateral or is paroxysmal. 2) Impaired pulsations of peripheral arteries. 3) Abnormal color of the skin, particularly when affected by raising or lowering the part. 4) Gangrene, ulceration, impaired nail and hair growth, excessive calluses, or paronychial infections. 5) Unusual warmth or coldness. 7) Swelling, atrophy, or difference in length of extremity. 8) Ausculatory evidence of arteriovenous fistula. 9) Cyanosis or unusual pallor of digits when immersed in cold water. 10) Peripheral neuritis.
 ...
PMID:Occlusive arterial disease in the lower leg and foot. 103 Jul 26

High titers cold agglutinins were demonstrated in the serum of a 7 year old female toy Pinscher with a hemolytic anemia. In vitro, the serum did not show distinct hemolytic properties, but it fixed complement components to both the patient's own red cells and randomly sampled canine erythrocytes and agglutinated these cells at high dilutions at low temperatures (optimally at 0 degrees C). Serum electrophoresis on cellulose acetate membranes failed to reveal a paraproteinemia. Normal canine red cells sensitized with the patient's serum at 0 degrees C and eluted at 40 degrees C, released a cold agglutinin identifiable as IgM by immunoelectrophoresis. Neither IgA nor IgG were detectable in a concentrate of the eluate. The auto-antibody showed no specificity against the canine blood group A antigen and did not react with human O-erythrocytes, irrespective of whether these carried the I- or i-antigens. Following erroneous exposure of the dog to cold, cyanosis and serious gangrene developed at the acra (the ears, nose and feet). In addition, symptoms indicating diffuse intravascular coagulation were observed both hematologically and on pathological-anatomical examination. No primary disease could be demonstrated.
 ...
PMID:Cold hemagglutinin disease in a toy Pinscher dog. 117 5

A moderate malignant hyperthermia developed in a Labrador Retriever anaesthetized with isoflurane for a femoral shaft fracture repair. Signs of malignant hyperthermia included progressive increases in PETCO2 and rectal temperature up to 39.8 degrees C, tachycardia, cyanosis, and elevated serum levels of potassium, inorganic phosphorus, AST, CK and alkaline phosphatase. Treatment initiated in the early recovery period consisted of hyperventilation with 100% oxygen, stomach lavage with iced water, body surface cooling, and intravenous administration of cold isotonic saline solution. Cooling was continued until the rectal temperature had dropped to 37.3 degrees C. After treatment the dog recovered uneventfully. Clinical signs, pathophysiology, therapy, prevention of malignant hyperthermia and its association with other disorders are discussed.
 ...
PMID:[Malignant hyperthermia as a complication of anesthesia in the dog]. 144 May 99

It is the purpose of this report to focus attention on the clinical features, diagnosis, and management of chronic pernio. Thirty-nine patients meeting our strict criteria for a diagnosis of chronic pernio were seen at the Mayo Clinic between 1976 and 1988 and form the basis for this report. Persons with upper extremity lesions only were excluded. Twenty-eight of the patients were female, 11 were male. Age at onset of symptoms ranged from 13 to 68 years of age, with symptoms appearing from 1 to 37 years following cold injury. The lesions were bilateral in 35 (90%) of patients and symmetric in 28 (71%). Nine patients who underwent skin temperature studies following cold water immersion, showed a vasospastic response. Chronic pernio is characterized by recurring erythematous, vesicular or ulcerative lesions of the lower extremities and toes, but may present with only digital cyanosis, usually bilateral and commonly symmetrical. The diagnosis is suggested by eliciting a temporal relation between cool weather and symptom onset, particularly if there is no associated occlusive peripheral arterial disease. Treatment consists of avoidance of cold and other vasoconstrictive influences. Prazosin has been effective in the acute management and as prophylaxis against recurrences.
 ...
PMID:Chronic pernio: another cause of blue toes. 152 52

In the experiment, frostbite of the hind legs in rabbits was induced for 3 hours. The extremities of 12 animals of the experimental group were influenced with UHF-field with a wavelength of 12.6 cm of nonthermal intensity (3 W) for 10 minutes one time after termination of cold influence. The extremities of 18 rabbits of the control group were warmed in a natural way. The milder course of cold trauma in animals of the experimental group manifesting itself in higher temperature of a skin of the damaged extremity, more rapid disappearance of edema and lesser spreading of cyanosis, tissue necrosis of an extremity--(7.6 +/- 2.5) and (11.7 +/- 1.2) cm, respectively--was noted. The authors consider that microwave therapy can be included into the complex of measures at the early period of treatment of local cold trauma.
 ...
PMID:[Microwave therapy of frostbite of the extremities]. 161 62

The value of dopexamine hydrochloride, a beta 2 agonist with dopamine-like and weak beta 1 effects, for the treatment of low cardiac output was investigated in twelve patients. All had undergone cardiac surgery (valve replacement, aorto-coronary bypass), and had a cardiac index (C1) less than 21.min-1.m-2, low urine output (17 +/- 23 ml.h-1), and poor peripheral perfusion (peripheral cyanosis, cold hands and feet). Systolic arterial blood pressure was decreased, but over 80 mmHg. Diastolic pulmonary arterial or wedge blood pressure was more than 15 mmHg. Usual haemodynamic monitoring was carried out using arterial and Swan-Ganz catheters. Dopexamine hydrochloride doses were increased every 15 min by increments of 1 microgram.kg-1.min-1, up to a maximum dose of 8 micrograms.kg-1.min-1, so as to determine the optimal dose for each patient. This dose was then given for a period of up to 48 h. During the initial titration phase, heart rate increased by 37% from control at a dose of 4 micrograms.kg-1.min-1, this increase becoming less important at higher doses (13% at 8 micrograms.kg-1.min-1). Mean arterial blood pressure increased by 13% at a dose of 2 micrograms.kg-1.min-1. Mean pulmonary arterial blood pressure did not change significantly, but wedge pressure fell by 25% at 4 micrograms.kg-1.min-1. Simultaneously, CI increased by 56%, and systemic vascular resistances decreased by 31% (p less than 0.005). During the continuous steady rate infusion period, heart rate fell to a level of about 100 b.min-1.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Dopexamine: a new catecholamine used in the treatment of low cardiac output after heart surgery]. 167 83

The medical records of six cases of nesidioblastosis were examined to determine the diagnostic approach, treatment, and neurologic sequelae. All six patients were male, and their ages at the onset of the disease ranged from one day to six months (mean 3.36 +/- 2.5 mo.). Initial clinical features were seizure, cyanosis, poor feeding, and apnea. Other subsequent symptoms were developmental delay, hyperactivity, and cold sweating. The Birth weight of the neonatal onset group was heavier than the postneonatal onset group (4.4 +/- 0.3 vs 3.26 +/- 0.04 kg). Before the diagnosis of hyperinsulinism, steroids of ACTH proved effective for seizure control. Initially, hyperinsulinemia (serum insulin greater than 10 microU/ml) was detected in four cases, but another two cases also showed hyperinsulinism by insulin/glucose(I/G) ratio greater than 0.3 during the fasting test. The glucagon response performed in 2 cases, showed normal and partial responses. Euglycemia was obtained by near total pancreatectomy (95% pancreatic resection)without malabsorption or persistent diabetes. In one case, nesidioblastoma coexisted with nesidioblastosis. Developmental delay was noted in three cases. In this group, the mean duration between symptom onset and operation was longer than the group without developmental delay (1.25 +/- 0.47 vs 0.38 +/- 0.19 yr).
 ...
PMID:A study on nesidioblastosis in hyperinsulinemic hypoglycemia--diagnosis, treatment, and neurologic sequelae. 171 Sep 1

We report a case of a 59-year-old male who suddenly developed massive right hemothorax and shock due to pulmonary arteriovenous malformation (AVM). He was admitted as an emergency case because of severe back pain, cyanosis and cold sweat. Although shock with massive right hemothorax was found, echocardiographic and X-ray computed tomographic examination showed no dilatation of the aorta, no intimal flap in the aorta and no pericardial effusion which suggested aneurysm. Pulmonary arteriography, performed subsequently, disclosed intrapleural rupture of the right pulmonary AVM. The patient recovered successfully from the state of shock. The pulmonary AVM was removed by segmentectomy of the right lung (S4). He was discharged following an uneventful postoperative course. Intrapleural rupture with shock is a very rare complication of pulmonary AVM. Pulmonary AVM should be considered as one possible cause in patients with massive hemothorax and shock.
 ...
PMID:[A case of intrapleural rupture of pulmonary arteriovenous malformation with shock]. 221 91


1 2 3 4 5 6 7 8 Next >>