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Query: UMLS:C0009443 (cold)
 92,137 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vasospasms in the eye are often combined with digital vasospasms, as can be diagnosed with a nailfold capillaroscopic local cooling test. In 16 patients with a history of cold hands and feet the presence of peripheral vasospasms without any underlying disease was demonstrated by means of nailfold video-capillaroscopy. These patients showed the phenomenologic diagnosis of low-tension glaucoma with visual field defects characteristic of glaucoma even though intraocular pressure above 21 mmHg was excluded. The visual field defects were not homonymous, indicating a prechiasmal location of the vascular disturbance. Ocular vasospasms cause visual field damage that can be aggravated or provoked by cooling one hand in cold water and that often improves after treatment with the calcium channel blocker nifedipine. The results suggest that vasospasms not only are present in Raynaud's disease, migraine, and Prinzmetal's variant angina but also may be an important factor in the genesis of low-tension glaucoma. This is a new finding and may be related to a general vasospastic syndrome.
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PMID:Do vasospasms provoke ocular diseases? 231 50

Our previous research has determined that the vascular "cold patch" is a valid diagnostic "marker" and is a persistent constituent of the thermal geography of the external carotid region. It has been suggested by Dalla Volta and Anzola (1988) that the cold patch may be a prognostic index of vascular headache physiology; that is, as headaches improve through the use of vasoactive prophylactic medication, the cold patch would decrease in size or disappear. The purpose of this study is an attempt to replicate these findings. Forty migraine patients were randomly selected, and a thermographic re-examination of the external carotid region (forehead) was conducted. The post-treatment thermogram was then compared to the initial pre-treatment thermogram. Thirty subjects demonstrated an improved condition (IC) and ten subjects a worsened condition (WC). The IC Group exhibited a 73.2% reduction in headache frequency following a mean treatment period of 6.3 months. The WC Group demonstrated a 48.1% increase in headache occurrence at a mean treatment interval of fifteen months. Results demonstrated little thermographic difference between the two conditions. Within the IC Group, 46.7% of subjects exhibited and increase in cold patch size with an improved condition, 40% of cold patches remained stable, 6.7% of cold patches reduced in size, and zero cold patches disappeared with successful treatment. Within the WC Group, 20% of cold patches decreased in size with a worsened condition, 40% increased in size, and 40% remained stable. Chi square analysis determined there was no significant difference in cold patch changes between patients whose headache condition improved or worsened (p less than .70).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:The vascular "cold patch" is not a prognostic index for headache. 258 93

Hand temperature norms are presented for 221 headache patients (migraine, mixed, and tension), 105 hypertensives, 45 irritable bowel syndrome patients, and 56 normal controls under conditions of resting baseline, self-relaxation, volitional handwarming, mental arithmetic, and cold pressor. The two vascular headache groups (migraine and mixed) had significantly lower hand temperatures across conditions.
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PMID:Hand temperature norms for headache, hypertension, and irritable bowel syndrome. 263 72

The vasospastic diseases form an important group of ailments. The recognition of the different types of vasospasms is essential if the physician is to correctly advise and treat. Attention must be paid to the history of attacks of cold hands and feet combined with a predisposition to migraine and hypotension. The high prevalence of migraine, Raynaud's phenomenon. Prinzmetal's variant angina and visual acuity disturbance of ophthalmologically unexplained origin in patients with peripheral vasospasms indicates the existence of a generalized vasospastic disease. There is most often no underlying disease detectable. In cases of unknown origin, supplementary investigations are necessary. The management of vasospastic disorders is still unsatisfactory at the present time. These difficulties reflect the uncertainty in the etiology and pathogenesis of the disorder.
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PMID:[Raynaud's syndrome: diagnosis and therapy in general practice]. 267 63

For clarification of possible platelet activation in migraine and chronic muscle contraction headache (MCH) under stress, plasma platelet factor 4 (PF4), norepinephrine (NE), and free fatty acids (FFA) were investigated during the cold pressor test. Both PF4 and NE increased significantly, whereas FFA showed no remarkable changes. The increases of PF4 in MCH and migraine during this test were significantly greater than in healthy controls. The increase of PF4, however, was independent of NE increase and FFA changes. On the other hand, we observed decreased NE levels in both MCH and migraine, which might suggest peripheral sympathetic hypofunction. The platelets of MCH or migraine patients seem to be impaired, and the impairment may be caused by continuous sympathetic hypofunction. The behaviour of the above three substances in MCH was similar to that in migraine throughout the present study.
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PMID:Muscle contraction headache and migraine. Platelet activation and plasma norepinephrine during the cold pressor test. 270 77

Patients with migraine who believed that red wine but not alcohol in general had a headache-provoking effect on them were challenged either with red wine or with a vodka and diluent mixture of equivalent alcohol content, both consumed cold out of dark bottles to disguise colour and flavour. The red wine, which had a negligible tyramine content, provoked a typical migraine attack in 9 of 11 such patients, whereas none of the 8 challenged with vodka had an attack. Neither red wine nor vodka provoked such episodes in other migrainous subjects or controls. These findings show that red wine contains a migraine-provoking agent that is neither alcohol nor tyramine.
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PMID:Red wine as a cause of migraine. 289 93

The occurrence of perceptual disturbances in migraineurs, particularly during the headache-free interval, has been scrutinized rather rarely. This subject was studied via a mail survey in 134 patients presenting perceptual changes before or during their migraine attacks. The patients had to complete a 5-part questionnaire covering history, events before, during as well as after the attack, and the attack-free interval. Sensory alterations during the headache-free interval were not reported by 36.6% of the patients. Alterations of equilibrium and/or spatial orientation, mainly susceptibility to motion sickness, were present in 47.8%, increased sensitivity to cold or heat in 40.3%, intolerance of tight clothes or being touched in 34.3%, altered visual function in 32.8%, changes in olfactory acuity in 31.1%. These percentages show that these 5 types of interictal sensory disturbances may not be rare in migraineurs. The exact frequency of these symptoms and how they correlate with perictal phenomena, sex, age and disease characteristics has to be further studied.
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PMID:The sensorium of the migraineur. 322 63

We measured blood flow in the finger in 38 control subjects with normal ocular findings without migraine, 13 control subjects with normal ocular findings with classic migraine, 17 patients with low-tension glaucoma with classic migraine, and 29 patients with low-tension glaucoma without migraine. Three blood flow measurements were recorded: one at baseline, one after immersion in warm water (40 C), and one after ten seconds' exposure to cold water (4 C). The mean baseline flow and the mean flow after exposure to cold was lower in patients with low-tension glaucoma (P = .013 and P less than .001, respectively).
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PMID:Response of blood flow to warm and cold in normal and low-tension glaucoma patients. 333 92

Previous studies have suggested a high prevalence of migraine headache and Raynaud's phenomenon in patients with variant angina. These findings suggest increased reactivity to vasoconstrictor stimuli in the extremities in these patients. In this study we examined forearm vascular responses to a cold pressor test and intra-arterially infused norepinephrine and angiotensin II in patients with variant angina (mean age 60 +/- 4 years, n = 6) and those with other forms of ischemic heart disease or atypical chest pain (mean age 59 +/- 5 years, n = 8). Arm blood flow was measured by strain gauge plethysmography and forearm vascular resistance was calculated. There was no difference in forearm vasoconstrictive responses to a cold pressor test, norepinephrine or angiotensin II between the two groups of patients. Minimal forearm vascular resistance after 10 min of arterial occlusion was also similar between the two groups. Thus our study suggests that peripheral vasoconstrictive reactivity is not increased in patients with variant angina.
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PMID:Peripheral vascular reactivity in patients with variant angina. 343 3

In a 43-year-old woman with ECG changes of an acute anterior and posterior wall infarct, associated symptoms and biochemical findings, coronary angiography demonstrated normal coronary arteries and a normal variant in the course of the left coronary artery. Vasospasms in another vascular bed (migraine) and highly positive 201-Thallium scintigraphy during acral cold provocation speak for coronary spasm as cause of the myocardial ischaemia in this patient.
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PMID:[Myocardial ischemia with normal coronary vessels. Indication of a vasospastic etiology]. 366 38


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