Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0009402 (colorectal cancer)
 53,228 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 3330
Mol 2992
CRC 2258
p53 2002
KRAS 1670
catenin 1225
BRAF 1197
epidermal growth factor receptor 1139
gut 961
APC 924
carcinoembryonic antigen 854
MLH1 824
EGFR 822
vascular endothelial growth factor 762
TNM 727
CEA 686
MSH2 677
AKT 629
E-cadherin 613
caspase-3 597
cytokine 548
PI3K 545
cage 540
adenomatous polyposis coli 484
Bcl-2 459
beta-catenin 434
MAPK 424
colon carcinoma 420
p21 416
ERK 412
MSH6 411
mTOR 411
hMLH1 405
COX-2 377
VEGF 364
cyclin D1 354
cyclooxygenase-2 349
hMSH2 342
PIK3CA 339
tyrosine kinase 325
DLD 322
IL-6 321
thymidylate synthase 320
CD8 320
K-ras 317
insulin 311
STAT3 304
CD44 302
histone 298
PMS2 289
tumour suppressor 288
TNF 275
MEK 274
nodal 263
UTR 256
PTEN 255
NRAS 249
mucin 249
tumor necrosis factor 239
cyclooxygenase 237
c-Myc 225
interferon 219
ERK1 216
IFN 213
PARP 212
CD133 207
Ki-67 204
DCC 203
ras 202
HER2 201
vimentin 198
CD4 197
kit 194
glycoprotein 192
proliferating cell nuclear antigen 192
cancer susceptibility 192
HNPCC 190
matrix metalloproteinase 187
lymphoid 187
p38 186
ATP 185
netrin-1 184
IL-8 181
MMP-9 179
hemoglobin 177
collagen 175
dihydropyrimidine dehydrogenase 172
endoplasmic reticulum 167
survivin 165
chemokine 163
epidermal growth factor 161
p16 161
MUTYH 159
PD-1 156
FDG 154
proteasome 151
caspase-9 150
p65 150
BRCA1 145
EGF 144
JNK 142
proto-oncogene 142
c-myc 142
TCF 141
histone deacetylase 141
IL-10 140
ubiquitin 140
C-reactive protein 140
She 137
Pol 136
DSS 134
ROS 132
MRI 132
caspase-8 131
type II collagen 131
annexin V 130
albumin 130
PD-L1 128
RAF 128
topoisomerase I 127
NMR 127
N-cadherin 126
BRCA2 124
MYC 124
EMT 123
VEGFR2 123
p27 123
insulin-like growth factor 122
phosphatase 121
MMP-2 121
MET 120
MMR 119
receptor tyrosine kinase 119
inducible nitric oxide synthase 118
CTNNB1 117
IL-2 117
Carcinoembryonic antigen 116
SMAD4 115
CK20 111
p160 108
MMP9 107
methylguanine-DNA methyltransferase 106
thymidine phosphorylase 105
cytochrome c 105
interleukin-2 105
DNA methyltransferase 104
fibronectin 104
alkaline phosphatase 103
CCK 102
interleukin-6 102
ZEB1 102
epithelial cell adhesion molecule 102
TGF-beta 102
extracellular signal-regulated kinase 102
AS1 101
GSK 101
BAX 100
MSS 98
estrogen receptor 97
COX 96
more...
Disease
colorectal cancer 53228
cancer 28170
tumor 17079
colon cancer 5506
metastases 4055
carcinogenesis 3501
carcinoma 3484
tumorigenesis 2708
breast cancer 2105
adenoma 2048
adenocarcinoma 1963
liver metastases 1892
Colorectal Cancer 1873
tumor growth 1826
rectal cancer 1784
tumor progression 1720
gastric cancer 1435
polyposis 1252
lung cancer 1161
inflammatory bowel disease 1089
Dukes 1083
familial adenomatous polyposis 1045
Lynch syndrome 1015
APC 925
colitis 874
ulcerative colitis 838
primary tumor 831
melanoma 743
prostate cancer 726
dysplasia 682
obesity 659
hepatocellular carcinoma 640
pancreatic cancer 637
ovarian cancer 584
Crohn's disease 452
Colon 436
Colon 436
Colon 436
diabetes 422
endometrial cancer 387
neutropenia 376
non-small cell lung cancer 346
gastrointestinal cancer 345
liver cancer 336
Colon cancer 291
liver cancer 283
cervical cancer 283
leukemia 274
HNPCC 262
anemia 261
renal cell carcinoma 260
lymphoma 259
esophageal cancer 253
hypertension 241
lung metastases 241
esophageal cancer 239
aggressiveness 235
Rectum 227
Rectum 227
Rectum 227
Rectum 227
squamous cell carcinoma 221
tumor angiogenesis 220
carcinomatosis 211
sarcoma 192
bladder cancer 191
cardiovascular disease 188
tumor initiation 172
thrombocytopenia 171
bowel obstruction 169
head and neck cancer 156
intestinal cancer 148
depression 147
solid tumor 147
irritable bowel syndrome 147
stomatitis 146
glioma 144
glioblastoma 142
type 2 diabetes 141
cancer recurrence 135
DSS 134
DSS 134
cold 131
rash 130
primary sclerosing cholangitis 128
EMT 123
Hodgkin's disease 123
myelosuppression 119
liver disease 118
MTS 116
adenomatous polyp 115
skin cancer 115
metastatic colon cancer 114
Best 114
leukopenia 114
peripheral neuropathy 113
B-cell lymphoma 110
neuropathy 107
renal cancer 105
invasive cancer 103
neoplastic transformation 102
AS1 101
metabolic syndrome 100
multiple myeloma 100
West 99
MSS 98
cirrhosis 96
stroke 96
thyroid cancer 96
sepsis 95
residual disease 95
diverticular disease 95
MCF 94
familial cancer 93
hand-foot syndrome 90
sepsis 89
ATM 87
retinoblastoma 86
non-Hodgkin's lymphoma 86
lung carcinoma 83
neuroblastoma 81
GSH 80
Peutz-Jeghers syndrome 80
malnutrition 79
aggression 78
stage III colon cancer 78
SCID 76
ileus 74
adenocarcinoma of the colon 73
TAS 72
DDP 72
rheumatoid arthritis 71
mucinous carcinoma 70
metastatic breast cancer 69
epithelial ovarian cancer 68
osteosarcoma 66
coronary heart disease 66
Colitis 64
gallstones 63
Alzheimer's disease 63
Poland 62
ischemia 61
osteoporosis 60
acute myeloid leukemia 60
asthma 58
influenza 58
desmoid 58
Adenoma 58
Adenoma 58
minimal residual disease 58
Merkel cell carcinoma 57
mesothelioma 57
HIV 56
proteinuria 56
Metastatic colorectal cancer 56
stage II colorectal cancer 55
chronic disease 55
Blocking 55
pneumonia 54
stromal tumors 54
more...
Symptom
diarrhea 784
pain 356
nausea 276
vomiting 250
fatigue 223
abdominal pain 187
constipation 128
overweight 127
nausea and vomiting 121
discomfort 97
anorexia 95
discomfort 86
anesthesia 77
cachexia 56
asthenia 49
starvation 48
colic 40
dyspnea 40
headache 38
weakness 35
collapse 30
exhaustion 29
analgesia 27
Wind 26
chills 25
seizures 22
paresthesia 21
Ill 20
numbness 20
cough 19
angina 19
splenomegaly 16
erythema 16
tenesmus 16
chest pain 15
dizziness 15
dysesthesia 14
chronic constipation 13
myalgia 13
abdominal discomfort 13
bloating 12
insomnia 12
functional recovery 11
arthralgia 11
decreased appetite 11
hepatomegaly 11
back pain 11
intestinal bleeding 10
stigma 9
eds 9
hemoptysis 9
acidity 9
microbial colonization 8
pelvic pain 8
flushing 8
ataxia 8
Scratch 7
agitation 7
lethargy 7
acute abdomen 7
menopausal symptoms 7
cancer pain 6
urinary frequency 6
anal pain 6
DNA marker 6
dry skin 6
tremor 6
sleepiness 5
HSA 5
pallor 5
abdominal cramps 5
rigors 5
hot flashes 5
epigastric pain 5
hypoproteinemia 4
shortness of breath 4
Depressive symptoms 4
oliguria 4
thinning 4
vertigo 4
respiratory distress 3
low back pain 3
dysarthria 3
incoordination 3
tingling 3
abdominal fullness 3
physical appearance 3
stomach pain 3
dysuria 3
blurred vision 3
rectal pain 3
exertional dyspnea 3
spasm 3
eye pain 3
tinnitus 3
hoarseness 3
hypercapnia 3
wheezing 2
hypothermia 2
Excitability 2
physical symptom 2
forgetfulness 2
cerebellar ataxia 2
chest tightness 2
night sweats 2
right upper quadrant pain 2
fasciculation 2
spasticity 2
flank pain 2
Postoperative pain 2
disturbed balance 2
halitosis 2
memory loss 2
Severe diarrhea 2
heartburn 2
productive cough 2
tachypnea 2
left lower quadrant pain 2
Neurologic symptoms 2
syncope 2
POA 2
hip pain 2
regurgitation 2
acute abdominal pain 2
masculinization 2
Radiating pain 1
non-productive cough 1
despair 1
Chills and fever 1
Sedation 1
hot flushes 1
apathy 1
ataxic gait 1
Decreased activity 1
Cold intolerance 1
enuresis 1
consciousness disturbance 1
right lower quadrant pain 1
nasal congestion 1
hopelessness 1
precordial pain 1
chronic back pain 1
Sister Mary Joseph's nodule 1
labored breathing 1
feeling worried 1
facial pain 1
neuralgia 1
vasovagal attacks 1
chronic cough 1
fever of unknown origin 1
belching 1
cyanosis 1
change in stool 1
loss of balance 1
sore throat 1
prostatism 1
localized erythema 1
infant diarrhea 1
hyperoxia 1
sciatica 1
more...
Drug
Oxaliplatin 416
CPT-11 351
Bevacizumab 310
Cetuximab 308
Irinotecan 246
ROS 132
lysine 120
IL-2 118
Monit 111
ROC 100
Leucovorin 100
Panitumumab 100
ascorbate 80
GEO 69
CSF 66
vitamin E 65
Xeloda 56
MAP 51
Bifidobacterium 50
caffeine 48
Cardiovasc 47
IFN-gamma 46
Gefitinib 35
CTC 35
THF 35
CTC 35
Paraffin 34
Dermatol 28
CAM 28
NVP 27
Glutathione 25
Indomethacin 25
ADM 25
Herceptin 25
ABC 24
uPA 23
lactose 22
EPA 22
Leaf 22
Mutagen 21
Spectrum 20
Portal 19
ADR 18
G-CSF 18
MRC 18
Adriamycin 17
Sorafenib 16
Taxol 16
NADH 16
ALA 15
Ethanol 14
Erlotinib 14
CCL 14
BLM 14
TTC 13
Bortezomib 13
Imatinib 13
Histamine 13
Heme 12
citric acid 12
ACT 12
Lipiodol 12
VCR 12
Docetaxel 12
Fluorescein 12
CDX 11
CDX 11
Retinoic acid 11
Pemetrexed 11
ETS 10
CTX 10
VCR 10
Tarceva 10
Activin 10
IL-1ra 10
Vitamin A 10
Glycyrrhiza 9
Cimetidine 9
Doxifluridine 9
TAC 9
Cimetidine 9
ICI 9
Vitamin E 9
CTX 9
Spectrum 8
IL-11 8
Mesalazine 8
Gel 8
Tocopherol 8
TAT 8
nitroglycerin 8
Asthma 8
HCG 7
Aloe 7
Dasatinib 7
ENT 7
Taxotere 7
Ginseng 7
TAK 7
Olive oil 7
MOF 7
Tolfenamic acid 7
Alliance 7
IFN-beta 6
DNase I 6
Panorex 6
Arsenic trioxide 6
pyridoxal phosphate 6
Check 6
PTH 6
Simvastatin 6
BTC 5
Bayer 5
Myricetin 5
CTX 5
DM1 5
Asn 5
Nitric Oxide 5
FAD 5
CEA-Scan 5
Etoposide 5
CTT 5
Vorinostat 5
Urokinase 5
p75 5
MDM 5
niacin 5
RFP 5
Rosiglitazone 5
Estrogens 5
Raloxifene 4
NaI 4
NaI 4
Indocyanine green 4
Rimonabant 4
EE2 4
NH3 4
Everolimus 4
Infliximab 4
Celebrex 4
Riboflavin 4
ZnO 4
Serum albumin 4
Artesunate 4
Eniluracil 4
Mitomycin-C 4
Capsicum 4
NaI 4
Gleevec 4
BH4 4
Vioxx 4
Alanine 4
PTC 4
Vitamin B 4
CoCl2 4
Infliximab 4
AMC 4
Vatalanib 4
CoCl2 4
Eniluracil 4
more...
Enzyme
ERK 1805
mitogen-activated protein kinase 989
APC 930
luciferase 633
caspase-3 432
focal adhesion kinase 393
protein kinase 363
thymidylate synthase 337
MEK 332
PARP 239
dihydropyrimidine dehydrogenase 172
proteasome 153
dihydropyrimidine dehydrogenase 153
reverse transcriptase 131
AMP-activated protein kinase 120
caspase-9 118
glutathione S-transferase 112
GSK 109
thymidine phosphorylase 106
DNA methyltransferase 104
alkaline phosphatase 103
caspase-8 95
peroxidase 93
urokinase-type plasminogen activator 82
P-glycoprotein 80
protein kinase C 80
AMPK 79
lactate dehydrogenase 79
ACS 79
phosphatidylinositol 3-kinase 78
superoxide dismutase 78
catalase 76
methylenetetrahydrofolate reductase 75
methylenetetrahydrofolate reductase 75
AMPK 74
topoisomerase 73
phosphoinositide 3-kinase 71
topoisomerase 70
ATPase 66
MMP 65
DNA polymerase 62
RNA polymerase 57
collagenase 55
ornithine decarboxylase 48
cdc2 48
MAP 47
aldehyde dehydrogenase 46
aldehyde dehydrogenase 43
aldehyde dehydrogenase 42
aldehyde dehydrogenase 42
aldehyde dehydrogenase 42
NQO1 40
granzyme B 38
UDP-glucuronosyltransferase 38
thymidine kinase 38
pyruvate kinase 37
N-acetyltransferase 36
prostate-specific antigen 36
glutathione peroxidase 36
calcineurin 36
PDK1 35
gamma-glutamyl transpeptidase 34
trypsin 33
transcriptase 31
ALDH 30
RNase 30
cathepsin D 30
cathepsin B 29
CPT 29
RNase 29
caspase-1 29
aspartate aminotransferase 29
BAT 29
CPT 28
CPT 28
dihydrofolate reductase 27
glyceraldehyde-3-phosphate dehydrogenase 25
carboxylesterase 25
endonuclease 24
IKK 23
lipoxygenase 23
carbonic anhydrase 23
phospholipase A2 23
MIP 22
alanine aminotransferase 22
phosphodiesterase 22
matrix metalloproteinase 9 22
histone demethylase 21
thrombin 21
glutathione reductase 21
STK11 21
15-hydroxyprostaglandin dehydrogenase 21
ACE 21
phospholipase C 20
matrix metalloproteinase 2 20
15-lipoxygenase 20
tissue plasminogen activator 19
demethylase 19
MDR 19
renin 18
CYP3A4 18
caspase-7 17
DNA ligase 17
DNA ligase 17
CD10 17
caspase-7 17
NADPH oxidase 17
methionine synthase 16
NADPH oxidase 16
methionine synthase 16
ribonucleotide reductase 16
complex I 16
MMP-3 15
guanylate cyclase 15
arginase 15
glyceraldehyde-3-phosphate dehydrogenase 15
histone acetyltransferase 15
neuraminidase 14
alcohol dehydrogenase 14
orotate phosphoribosyltransferase 14
cytosine deaminase 14
ribonucleotide reductase 14
prostaglandin synthetase 13
sialyltransferase 13
sialyltransferase 13
folylpolyglutamate synthetase 13
succinate dehydrogenase 13
sialyltransferase 13
glyceraldehyde-3-phosphate dehydrogenase 12
MTD 12
glyceraldehyde-3-phosphate dehydrogenase 12
lysyl oxidase 12
glyceraldehyde-3-phosphate dehydrogenase 12
lysozyme 11
HK2 11
peroxiredoxin 11
beta-glucuronidase 11
enolase 11
protein phosphatase 2A 11
beta-galactosidase 11
hexokinase 10
NOS 10
thioredoxin reductase 10
ATP synthase 10
creatine kinase 10
TdT 10
glutaminase 10
indoleamine 2,3-dioxygenase 10
kinesin 10
xanthine oxidase 10
GRK2 9
hyaluronidase 9
cytidine deaminase 9
PKG 9
ricin 9
PGM 9
thromboplastin 9
ribonuclease 9
ribonuclease 9
TACE 9
more...
Compound
DNA 5448
Clin 4651
Dec 3581
5-FU 1145
TNM 727
oxygen 682
MTT 600
sodium 594
calcium 551
water 476
sulfate 449
glucose 420
folinic acid 384
CPT-11 343
vitamin D 311
tyrosine 311
barium 278
TNF 275
MEK 269
iron 266
Pac 263
methionine 259
DCC 203
ASA 198
ATP 185
ethanol 178
serine 173
phosphate 171
acetate 166
lysine 163
bromide 158
SN-38 152
galactose 138
cysteine 137
DSS 135
iodine 134
threonine 134
Capecitabine 134
arginine 132
PEG 125
zinc 123
hydrogen 123
leucine 120
selenium 119
1,2-dimethylhydrazine 113
Curcumin 112
PGA 101
nitrogen 101
His 101
GSH 99
GSH 99
COX 96
alanine 96
MDA 95
PGE 93
Leucovorin 91
nitric oxide 90
MMC 90
pyrimidine 88
pyrimidine 87
butyric acid 84
ZD1694 83
Vimentin 82
FAP 82
FAP 82
ACS 79
ACS 79
PEG 75
salt 72
creatinine 72
TOF 71
Vitamin D 69
dUTP 67
glutamine 66
Insulin 63
PGE2 63
copper 63
DFS 62
formaldehyde 61
retinoic acid 59
homocysteine 57
potassium 57
urea 56
N-acetylcysteine 56
Optimal 55
DDP 55
Metformin 54
Celecoxib 54
Metformin 54
MTS 54
PMA 51
ADP 51
uridine 51
cAMP 50
MAP 49
Asp 49
NAD 48
caffeine 48
silver 48
fluorine 47
pyridine 46
Sulindac 46
HCA 46
glutamate 45
tryptophan 45
ADP 43
nicotinamide 43
aldehyde 43
GTP 43
valine 43
ADP 43
retinol 42
proline 42
acetic acid 40
CO2 40
FUDR 40
AMP 40
ADR 39
Resveratrol 38
ammonia 38
tryptophan 38
tryptophan 38
tryptophan 38
Tegafur 37
GlcNAc 37
NAD 36
CAM 36
SDS 35
Gly 35
ADP-ribose 35
Adriamycin 34
NH2 34
Ile 34
boron 33
Phe 33
ethyl acetate 32
H2O2 32
TEM 32
cGMP 32
methanol 32
GalNAc 31
Estrogen 31
H2S 31
butyric acid 30
Estrogen 30
hyaluronic acid 30
5-formyltetrahydrofolate 30
EDTA 29
EDTA 29
nitrate 29
CPT 28
CPT 28
THP 28
THP 28
MeCCNU 27
Histone 27
Trifluorothymidine 27
Collagen 27
Azoxymethane 26
aldehyde 26
more...