Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0009402 (
colorectal cancer
)
53,228
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Colorectal cancer
(
CRC
) is characterized by the accumulation of genetic and epigenetic alterations in neoplastic processes. DNA methylation, as an important epigenetic process, contributes to the development of
CRC
. In the present study, the epigenetic landscape of genes in
CRC
was characterized by analyzing the dataset from The Cancer Genome Atlas database and 177 DNA-methylated genes were screened based on the criterion of the Pearson correlation (R) between expression and methylation levels being >0.4. Pathway enrichment analysis revealed prominent pathways, including transcription and metabolism, further implying their significant role in tumorigenesis. Among the methylated genes, only zinc finger protein (ZNF)726 with aberrant expression was determined to affect overall survival (OS) as well as disease-free survival of patients with
CRC
. In addition,
ZNF726
was identified as an independent prognostic risk factor for OS in patients with
CRC
. The methylation-based regulation of
ZNF726
expression in
CRC
cells was further assessed using the Cancer Cell Line Encyclopedia database. Finally, the CpG island methylation of the
ZNF726
promoter was evaluated to further elucidate its role in the development of
CRC
. In conclusion, the epigenetic landscape of genes in terms of promoter methylation in
CRC
was characterized, revealing that aberrant expression of
ZNF726
may be an independent prognostic risk factor for OS in patients with
CRC
.
...
PMID:DNA-methylated gene markers for colorectal cancer in TCGA database. 3225 91
