Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0009402 (colorectal cancer)
 53,228 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)


CRC Crit Rev Clin Lab Sci 1975 Sep
PMID:Current status of laboratory diagnosis of Pneumocystis carinii pneumonitis. 5 30

One hundred eight patients have undergone major hepatic resection by the senior author during the eight year period April 1970 to April 1978. Primary liver cancer was present in 36; metastatic colorectal cancer in 25, miscellaneous metastatic cancers in 15, hepatoblastoma in 5, gallbladder cancer in 4, and bile duct cancer in 3. Benign tumors, principally giant hemangioma, were resected in 20 additional patients. The 30 day operative mortality rate was 9% overall. Prior to 1975, 41 of the resections were done using the vascular isolation perfusion technique. The operative mortality rate of 17% for this technique is a reflection of early experience and the advanced stage of disease of many patients. The operative mortality for the standard resection has been only 4%. Subphrenic abscess has developed in only 13% of patients during the past three years. Postoperative hospitalization has been shortened, being a median of 13 days. The resectability rate for malignant disease was 33%. Forty-six percent of the resections were performed with curative intent. Fifty-four per cent were palliative, performed in individuals with regional spread or distant metastasis. After curative surgery, three year survival was 88% for individuals with primary liver cancer and 72% with metastatic colorectal cancer. After palliative resection, the rates were 31 and 0%, respectively. The three year survival rate is 46% overall, being 81% for the curative resection group and 18% for the palliative group. Tumor markers proved useful in monitoring patients after hepatic resection.
Ann Surg 1978 Sep
PMID:Major hepatic resection for neoplasia: personal experience in 108 patients. 8 Jan 63

Serum pregnancy-associated alpha2-glycoprotein (alpha2PAG) levels have been measured in 67 patients with colorectal cancer. Postoperative changes in alpha2PAG concentrations were observed in patients undergoing apparently curative surgery and compared with results in patients with residual local or metastatic tumour. Significant increase in alpha2PAG levels were found only in those patients with residual or disseminated tumour. In this study alpha2PAG levels closely paralleled the clinical course of the disease in many patients.
Br J Surg 1978 Sep
PMID:The value of pregnancy-associated alpha2-glycoprotein in patients with colorectal cancer. 8 Oct 85

Cancerembryonic antigen (CEA) and beta2-microglobulin (beta2m) have been measured in cancer patients and patients with benign diseases. Of 168 patients with intestinal cancer, almost 90% had increasing concentrations of either CEA or beta2m or both. In 29 patients at different stages of pancreatic cancer there was a high incidence of increased values in the more severe cases. In 60 patients with histologically classified colorectal cancer the TNomegaMomega group of 19 patients had 47% and 42% of elevated beta2m and CEA respectively. A significant correlation of beta2m or CEA to extension of disease was noted. In benign intestinal disease like cirrhosis and pancreatitis both beta2m and CEA is commonly elevated. Of 26 breast cancer patients, seven had elevated CEA and five had elevated beta2m values before treatment. In the patients with extraganglionary metastasis almost 90% had high beta2m or CEA or both. Of 40 patients with uterine cancer, 26 were found to have increased values of beta2m or CEA or both. Finally, 140 colorectal cancer patients, 62 patients with breast cancer and 10 patients with uterine cancer have been followed longitudinally.
Pathol Biol (Paris) 1978 Sep
PMID:[beta2-Microglobulin in cancer patients (author's transl)]. 8 77

Selection of patients who might benefit from urinary diversion when recurrent colorectal cancer obstructs both ureters is difficult. Combinations of chemotherapy and radiation therapy will prolong a useful, comfortable and dignified life in some patients. Radiation therapy seems to be more effective than chemotherapy and, therefore, patients most likely to benefit are those with localized pelvic recurrences without carcinomatosis and those who are well nourished, active and highly motivated. Herein we discuss 6 patients who were diverted and the methods of selection.
J Urol 1979 Sep
PMID:Urinary diversion for ureteral obstruction in the presence of recurrent colon carcinoma. 8 5

Storage of frozen fish brings about a decrease of extractability of myofibrillar proteins. There is also deterioration of the texture and functional properties of the flesh. In model systems, aggregation of myosin, actin, tropomyosin, and whole myofibrils have been described. These changes are caused by concurrent action of partial dehydration due to the freezing out of water, exposure of the proteins to inorganic salts which are concentrated in the remaining nonfrozen fluid, interactions with free fatty acids liberated from phospholipids and with lipid oxidation products, and cross-linking by formaldehyde produced in some species of fish as a result of enzymic decomposition of trimethylamine oxide. The extent of protein alterations increases with time and temperature of storage as well as with advanced disintegration of the tissues and intermixing of their components. The role played by the individual factors and the significance of different types of bonds, i.e., hydrophobic adherences, ionic bonds, and covalent cross-links in particular cases are not yet fully disclosed. Retardation of the deteriorative changes of proteins in frozen fish is possible by avoiding high storage temperatures and oxidation of lipids, removing hematin compounds and other constituents promoting cross-linking reactions, and by adding cryoprotectors like sugars, several organic acids, amino acids, or peptides.
CRC Crit Rev Food Sci Nutr 1976 Sep
PMID:Protein changes in frozen fish. 14 88


CRC Crit Rev Clin Radiol Nucl Med 1976 Sep
PMID:Ultrasonography in obstetrics and gynecology: historical notes, basic principles, safety considerations, and clinical applications. 18 32

Primitive unicellular organisms depend greatly on internalization of particulate matter for nourishment. In metazoa, this process is further developed to play a major role in mechanisms of defense. This review analyzes, mainly in mammalian systems, the various phenomena surrounding the phagocytic act. Much of the emphasis is placed on experimental work which has recently elucidated some of its features. Both the structural and functional aspects of phagocytosis are considered throughout the review, which is subdivided into an examination of chemotaxis and the various agents inducing it, the mode of recognition of particles to be phagocytized, and the mechanisms of ingestion. The last includes a discussion of the possible means whereby recognition is translated into ingestion, the modes of adhesion of particles onto the surface of phagocytes, the formation and fusion of pseudopodia during engulfment and ingestion, and process and significance of degranulation. In addition, the metabolic changes in phagocytes during the processes of chemotaxis, ingestion, and digestion are described. A discussion of the various ways phagocytes may destroy microorganisms incorporates an appreciation of the importance of the microbicidal action of the acidic environment of the phagosome, the various lysosomal contents, hydrogen peroxide, superoxide, singlet oxygen, and chemiluminescence. The interdependence and interrelationship of the induction and cooperation of these mechanisms are examined.
CRC Crit Rev Toxicol 1978 Sep
PMID:Phagocytosis: a review. 21 Sep 92


CRC Crit Rev Microbiol 1978 Sep
PMID:Experimental evolution in bacteria. 21 53

Recent work in the field of cell pH has been characterized by many developments in techniques of measurement, by increasing knowledge of the mechanism of control of cell pH, and by progress in the establishment of relationships between cell pHi and certain areas of intermediary metabolism. Though the weight of evidence is much in favor of control cell pH by active transport of H+, the situation remains somewhat unsatisfactory due to lack of a completely adequate explanation of the work of Carter's group. The heterogeneity of cell pH raises problems in the intrepretation of hydrogen ion equilibria across cell membranes and serious difficulties in correlating changes with alterations in metabolism. To put this into perspective, however, the later difficulties are no greater than many experienced with cell constituents other than hydrogen ions.90 As in other fields, knowledge must advance by making the best of the currently available methods until such time as better techniques become available.
CRC Crit Rev Clin Lab Sci 1975 Sep
PMID:Intracellular pH: measurement, control, and metabolic interrelationships. 24 90


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