Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0009402 (colorectal cancer)
 53,228 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to evaluate the serum carcinoembryonic antigen levels in the diagnosis and in monitoring colorectal cancer patients at different Dukes' stage. Carcinoembryonic antigen serum levels were measured by Elisa using Sorine Biomedica kit (normal value: 5 ng/ml) in 240 colorectal adenocarcinoma. In the diagnosis, carcinoembryonic antigen levels were measured in 109 patients, in 42% of them, the carcinoembryonic antigen levels were elevated. The carcinoembryonic antigen levels were also evaluated in 309 serum from treated colorectal cancer patients. Fifty-nine percent of the serum of the patients with recurrence disease had elevated carcinoembryonic antigen levels and 41% of the serum of patients without recurrence also have elevated serum carcinoembryonic antigen levels. Ninety percent of the serum from treated patients without recurrence have normal serum carcinoembryonic antigen levels. We concluded that the sensitivity of carcinoembryonic antigen is lower in the diagnosis as described in others studies, mostly in patients with better prognosis. In the monitoring, patients with normal serum carcinoembryonic antigen levels, probably have no recurrence of the disease. In the other hand, patients with elevated serum carcinoembryonic antigen levels can have or not relapsed disease.
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PMID:[Carcinoembryonic antigen in diagnosis and monitoring of colorectal cancer]. 945 53

Carcinoembryonic antigen has been used to monitor colorectal cancer treated patients, elevated carcinoembryonic antigen allows to predict recurrence however some serum levels is not ever a sign of disease. In a last paper 21% of the colorectal cancer patients treated surgically had not recurrent disease. The aim of the study was to follow these patients for at least one year. Thirty two patients with elevated carcinoembryonic antigen serum levels were studied. Five were excluded and 27 were followed with chest RX, computadorized tomography and colonoscopy. Carcinoembryonic antigen serum levels were measured by ELISA using Sorine Biomedica kit (normal value: 5 ng/ml). Eleven patients (41%) developed recurrence, seven had liver metastasis. The mean time among the elevated serum carcinoembryonic antigen and the recurrence was 6.6 months. The recurrence was not observed in 18 patients, the carcinoembryonic antigen serum levels become normal in eight and in the eight others the carcinoembryonic antigen serum levels persisted elevated. Carcinoembryonic antigen serum levels can be elevated before the diagnosis of recurrence, mostly in liver metastasis, however, a number of patients with elevated carcinoembryonic antigen serum levels do not have a known cause.
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PMID:[Increased carcinoembryonic antigen and absence of recurrence in monitoring colorectal cancer]. 981 74