Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0009319 (colitis)
 19,384 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnosis and management of dilatation of the colon and free intestinal perforation in inflammatory or infective bowel disease are reviewed with reference to 32 cases seen during an 8-year period. Toxic dilatation of the colon occurred in 20 patients, including 6 with infective colitis. Ileostomy with subtotal colectomy and mucous fistula is a satisfactory operation for toxic dilatation due to inflammatory bowel disease. Patients with infective colitis can generally be treated without operation. Free intestinal perforation was seen in 12 patients. Colonic perforation may occur in association with toxic dilatation, but more usually it occurs without dilatation as a complication of Crohn's disease. Free perforation of the ileum was seen after a short illness in patients with Crohn's disease.
 ...
PMID:Toxic dilatation and perforation in inflammatory bowel disease. 711 66

Although malnutrition is common in Crohn's disease, some features are often overlooked. We have examined the value of simple anthropometric measurements in identifying the patients who were likely to have clinical features of malnutrition. Measurements were performed in 106 patients with Crohn's disease, 106 with ulcerative colitis and 106 healthy controls; all measurements were significantly reduced in patients with Crohn's disease (P less than 0.01) compared with controls and colitis patients who had similar measurements. Patients with Crohn's disease most severely affected had diffuse small bowel disease or recurrent disease following surgery. Those who had previous resections but no recurrence were similar to controls. Crohn's patients with colonic and ano-rectal disease were similar to patients with colitis. Anthropometry provides a simple method of documenting the nutritional status of patients with inflammatory bowel disease and helps to identify those with both clinical and biochemical features of malnutrition.
 ...
PMID:Malnutrition in inflammatory bowel disease: an anthropometric study. 714 85

In a 5-year period 48 (14%) of 336 patients with ulcerative colitis were found to have hepatobiliary disease. The bile ducts were examined in 35 of these patients, and optimal visualization of both intra- and extra-hepatic bile ducts was obtained in 26. Duct changes compatible with sclerosing cholangitis were found in 14 patients. This finding of sclerosing cholangitis in 4% of all patients admitted with ulcerative colitis by far exceeds previous estimations on the incidence of sclerosing cholangitis in ulcerative colitis. The entire colon was usually affected, and the symptoms of the bowel disease were most often mild or moderate. The age at the onset of the colitis was usually below 20 years in patients with combined ulcerative colitis and hepatobiliary disease. In most patients the hepatobiliary disease gave no symptoms. Biochemical data and the histological findings in the liver biopsies did not distinguish between patients with hepatobiliary disease with and without sclerosing cholangitis. Our follow-up study has so far shown that most patients with sclerosing cholangitis remain asymptomatic for a considerable period of time.
 ...
PMID:Sclerosing cholangitis in ulcerative colitis. 720 79

To determine the features of Crohn's disease in elderly patients we reviewed the charts, roentgenograms and pathology of patients with Crohn's disease admitted to our hospital from 1966 through 1979. Thirty-three patients (5.2% of the total) had the onset of symptoms and diagnosis made after age 60, including 18 (55%) with ileitis alone, 11 with colitis and four with ileocolitis. Six patients were seen, four with colitis and two with ileocolitis, with acute toxicity requiring early surgery. The clinical, radiographic and histologic characteristics of the disorder in older patients were otherwise similar to those described in younger patients. Differentiation of ischemic bowel disease and diverticulitis from Crohn's disease in such patients was difficult without reliance on histologic as well as clinical and roentgenographic features. Fifty-eight per cent of these older patients eventually required surgery, including 10 of 11 (91%) with colitis, two fo four with ileocolitis and seven of 18 (39%) with ileitis. The cumulative clinical recurrence rate, limited to patients with ileal disease, was 21% at nine years and 37% at 15 years.
 ...
PMID:Crohn's disease in the elderly. 730 48

Thrombophlebitis migrans complicating ulcerative colitis has been reported only once previously when it occurred in a patient with chronic and extensive bowel disease. This report describes the occurrence of thrombophlebitis before any bowel upset in a patient who proved to have only a mild colitis, and no laboratory evidence of hypercoagulability. It seems that thrombophlebitis migrans is a further systemic complication of ulcerative colitis, and that its occurrence may precede overt bowel disease.
 ...
PMID:Thrombophlebitis migrans: a further systemic complication of ulcerative colitis. 739 15

Neutropenic colitis, a severe necrotizing enteropathy, is being recognized with increasing frequency as a life-threatening complication of aggressive chemotherapy mainly for lymphoproliferative and hematologic malignancies. It is often under-recognized clinically, despite its potentially lethal outcome. Both medical and surgical approaches to management are possible. We describe a case of neutropenic colitis involving predominantly the transverse colon in a patient successfully treated for limited-disease small cell lung cancer. This is only the second reported case of neutropenic colitis complicating chemotherapy for small cell lung cancer. A brief review of the diagnosis, clinical features, and management is presented.
 ...
PMID:Fatal neutropenic colitis complicating successful chemotherapy for small cell lung cancer: a case report. 774 95

We conducted this study to determine if color Doppler ultrasonography can identify increased vascularity associated with gastrointestinal inflammatory conditions and to determine if specific diagnoses can be established based on flow patterns. Twenty-five children with acute right lower quadrant pain and discharge diagnoses of inflammatory bowel processes were examined by color Doppler sonography, as an adjunct to routine gray-scale examinations. Final diagnoses included gastroenteritis (10 cases), Crohn's disease (five cases), neutropenic colitis (four cases), peritonitis (four cases), and Yersinia enterocolitis (two cases). The results of color Doppler sonography were considered positive for inflammation if increased vascularity was demonstrated in the bowel mucosa, muscularis layer, or adjacent tissues. A control group of 19 patients was examined. No sonographic abnormalities were identified in any patients in the control group. Diffuse, concentric wall thickening with increased blood flow centrally within the mucosa was seen in Crohn's disease (60%) and Yersinia enterocolitis (100%), whereas wall thickening with increased transmural vascularity was identified in neutropenic colitis (50%) and Crohn's disease (40%). In contrast, in peritonitis color Doppler sonography showed thickened bowel wall and hypervascularity within peripheral bowel wall or in adjacent soft tissues. No demonstrable bowel vascularity was seen in gastroenteritis. Our experience suggests that mucosal or transmural hypervascularity on color Doppler sonography can be seen with several inflammatory bowel processes, but it is nonspecific. However, color Doppler sonography may aid in differentiating primary bowel disease from extrinsic inflammatory conditions, such as peritonitis.
 ...
PMID:Gastrointestinal inflammation in children: color Doppler ultrasonography. 782 36

To evaluate the importance of fecal leukocytes, 42 patients who showed signs of fecal leukocytes (++ or +++) were studied. Their endoscopic examinations with biopsy and/or radiology of the colon showed the following diagnoses: 33 had ulcerative colitis, four had colonic adenocarcinoma, two had Crohn's disease, two had amebic colitis and one had eosinophilic colitis. The presence of fecal leukocytes allowed for the diagnosis of colon disease in all the patients, and it might indicate exudative bowel disease. These results suggest that whenever fecal leukocytes are found in the feces, an examination for colon disease should be made.
 ...
PMID:Diagnostic value of fecal leukocytes in chronic bowel diseases. 787 15

This study newly introduces anti-VH mAbs to assess the role of clonal B cell activity in inflammatory bowel disease. Immunohistochemistry of colonic biopsies in ulcerative colitis (UC) and Crohn's disease (CD), but not unaffected individuals, demonstrated uniform staining of intravascular erythrocytes with BK2, a monoclonal specific for the VH3-15 Ig heavy chain gene product. Staining was caused by erythrocytes opsinized in vivo by anti-erythrocyte Abs present in patient sera and by using the VH3-15 gene product. The erythrocyte Ag was identified by immunoprecipitation as 22- and 28-kDa membrane proteins. A direct flow cytometric assay was developed to measure this serum autoantibody and was tested in 101 individuals with UC, CD, other acute or chronic colitis, and healthy controls. Compared with normal subjects, BK2+ anti-erythrocyte Abs were elevated in most sera from patients with CD and UC (including postcolectomy). BK2+ anti-erythrocyte Abs also were elevated in 10 of 38 noninflammatory bowel disease patients, all of whom had Campylobacter jejuni enterocolitis. These findings suggest that a common immunopathogenetic factor, manifested by VH3-15 B cell activation may be shared in UC, CD, and Campylobacter jejuni enterocolitis.
 ...
PMID:Expression of a novel autoantibody defined by the VH3-15 gene in inflammatory bowel disease and Campylobacter jejuni enterocolitis. 793 May 92

Between 1974 and 1992, we perform 3,054 colonoscopies for diagnosis in 2,770 patients, both of sexes, between the ages of 1 and 101 yr, most of them over the fifth decade of life. In 300 procedures the bowel cleansing was made with the standard method of liquid diet and enemas, and in the other 2,754 with the oral administration of saline solution 9% with optimal results. We get the sedation of patients with the intravenous administration of diazepam 10mg, or pethidine 50 mg, or midazolam 2.5 to 5 mg, and in children with ketamine and the anesthesiologist assistance. In 95% of the procedures we can see the cecum and the ileum; the diagnosis was abnormal in 52.78% of cases, normal in 45.20%, and insufficient in 02.02% specially for a bad cleansing of the bowel. In the abnormal group, the most frequent diseases we diagnose were: polyps, cancer, diverticular disease, and specific inflammatory disease of the bowel like TBC, radiation proctosigmoiditis, amebiasis, and non-specific bowel disease: "colitis", ulcerative proctocolitis, erosive colitis, and Crohn's disease. Colonoscopy is a very important method for diagnosis of colon diseases, alone or complementary of double contrast X-ray of the colon.
 ...
PMID:[Colonoscopic diagnosis]. 794 39


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>