Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0009319 (colitis)
 19,384 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

BRL 25000 granules containing 2 parts amoxicillin and 1 part potassium clavulanate were administered to children suffering from acute infections at a daily dose of 50 mg/kg in 3 or 4 divided doses for at least 3 days. Infections included acute airway infections (81), scarlet fever and suspected scarlet fever (4), urinary tract infections (4), impetigo contagiosa (1) and acute colitis (1). Bacteria were eradicated in 91.3% (63/69) of cases treated with the BRL 25000 granules, with only 2 strains of Staphylococcus aureus, 2 of Escherichia coli, 1 of Haemophilus influenzae and 1 of Streptococcus pneumoniae remaining. Eight beta-lactamase producing strains were detected amongst the 49 clinical isolates studied and of these, 6 were eradicated after administration of the BRL 25000 granules. Good clinical efficacy was obtained in 97.8% of cases (89/91), with 1 case of acute tonsillitis and 1 of acute colitis showing no improvement. Adverse reactions were limited to 1 case of vomiting and 3 of diarrhea, and no abnormal laboratory findings were detected.
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PMID:[Experimental and clinical evaluation of the BRL 25000 (clavulanic acid-amoxicillin) granules in the pediatric field]. 400 49

Patients with acquired immunodeficiency syndrome (AIDS) frequently have diarrhea and weight loss. We prospectively examined the upper and lower gastrointestinal tracts in 22 AIDS patients, although severe medical problems often precluded full evaluation. Ninety-six percent (21 of 22) lost weight, and 55% (12 of 22) had diarrhea. The mean (+/- SD) weight loss was 34 +/- 19 lb. Steatorrhea was found in 4 of 14 patients, and D-xylose tests were abnormal in 8 of 14 patients. Mean serum albumin was 3.3 +/- 0.8 g/dl. A significantly diminished plasma selenium level, which can influence immune function, was noted in these AIDS patients. Gastrointestinal infections were identified in 45% of patients. Although diarrhea and malabsorption were more common in the infected group, weight loss and albumin were similar in those with and without demonstrated infections. Flexible sigmoidoscopy showed that of 15 patients, there were two with Kaposi's sarcoma, 10 normals, and three with nonspecific endoscopic changes of colitis. Infection was documented in all patients with colitis. Panendoscopy of the upper gastrointestinal tract was positive for AIDS-related pathology in five of 10 patients, including two with Kaposi's sarcoma, one with Candida esophagitis, one with herpetic esophagitis, and one with gastroduodenitis (biopsy positive for cryptosporidia); five patients had a normal-appearing tract. Small bowel or colonic biopsies frequently showed nonspecific inflammatory changes, although pathogens were identified in six patients (27% of all biopsies). We conclude that a wide variety of gastrointestinal pathology, which includes infectious agents, neoplasms, and inflammatory changes, may occur in AIDS patients. Therefore, AIDS patients, particularly those with diarrhea or weight loss, deserve an intensive evaluation for remediable lesions of their gastrointestinal tracts.
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PMID:Gastrointestinal manifestations of the acquired immunodeficiency syndrome: a review of 22 cases. 404 Nov 33

The data presented indicate that the disturbing upward trend in infant mortality in North Carolina has been arrested and possibly reversed during the 1959 through 1963 period. Information obtained from death certificates indicates that infections accounted for slightly more than half (52.4%) of the postneonatal deaths occurring in the study periods. The most common type of infection was influenza and pneumonia, followed by gastroenteritis and colitis, infective and parasitic disease, meningitis, and acute respiratory infections, in that order of frequency. Infections were responsible for a greater percentage of the postneonatal deaths among nonwhite (58.5%) than amon white infants (40.7%). the postneonatal death rate from infections was 13.4 for nonwhite infants and 2.2 for white infants. The next most common cause of postneonatal mortality -- congenital malformations -- was relatively more important in the white race, being responsible for approximately 25% of white deaths and only 6% of nonwhite deaths. I11 defined and unknown causes ranked 3rd in importance, with postneonatal death rates of 3.0 for nonwhite and .4 for white infants. Accidents, wich ranked 4th, were responsible for approximately 10% of the postneonatal deaths in each race. In both races, the risk of postneonatal death was greater in infants born to younger mothers, partiuclarly those under age 20. For the infants of mothers under age 15, the postneonatal death rate was 3 times as high as for those of 20-24 year old mothers. Beginning with age 20, the risk of postneonatal mortality decreases gradually as maternal age increases up to 35 years, when it begins to rise again in the white race. In nonwhite races, the decline continoues to age 40. Infants born to young mothers of nonwhite races suffer relatively higher postneonatal mortality than do their white counterparts. The postneonatal mortality rate is lowest for 1st born infants of both races. Among nonwhites, it is highest for the 2nd born; in the white race, it rises with each successive birth, with the exception of the 5th. Postneonatal mortality among very small white infants (those weighing less thatn 1500 gm at birth) was some 7 times that of infants weighing more than 2500 gm; it was even higher in nonwhite races being nearly 2 1/2 times that of the white group and appoproximately 4 times higher than the rate for nonwhite infants weighing more than 2500 gm at birth. The risk of postneonatal death for nonwhite infants born illegitimately was 1 1/2 times as great for those born in wedlock. Among white infants, the risk was almost twice as great for those born out of wedlock.
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PMID:Postneonatal deaths in North Carolina, 1959-1963. 523 49

Clostridium difficile has become one of the commonest pathogens of the lower intestinal tract. This organism appears unique in that infection almost always occurs during or after antibiotic therapy, suggesting that some component of the normal microflora prevents colonization by C. difficile. Once it has overgrown in the colon, C. difficile releases several toxins which cause tissue damage and diarrhea. Infection can range from a simple self-limited diarrheal illness to fulminant colitis with perforation and megacolon. Assay of stool filtrates reveals the presence of cytotoxin in nearly all patients with antibiotic-associated pseudomembranous colitis, and in approximately one third to one half of those with less severe infections. Effective therapy is available in the form of oral vancomycin, although the expense of this antibiotic has led to the use of oral metronidazole or bacitracin, which appear to be equally efficacious and considerably cheaper. Although we have learned a great deal about C. difficile in the past decade, a number of fascinating puzzles remain. We know very little about the immune response to this organism or its toxin, or whether a vaccine might someday be feasible. Similarly, we have very little insight into what effects antibodies exert on the normal colonic flora and how these effects allow C. difficile infection in a small percentage of patients. Studies of this pathogen will undoubtedly lead to a fuller understanding of the enormously complex and still mysterious microbial ferment which lives within our gastrointestinal tract.
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PMID:Clostridium difficile colitis. 636 36

Twenty courses of fusidic acid were given to 16 patients with antibiotic-associated colitis caused by Clostridium difficile. Fusidic acid was given in a dose of 0.5-1.5 g daily for seven to 21 days. Diarrhoea disappeared rapidly. Clinical relapse occurred after five courses and once when the patient was still on treatment. Clinical cure with persistence or reappearance of toxin occurred in four further patients. Nineteen courses of metronidazole were given to 19 patients who experienced six failures or relapses. Seven courses of vancomycin were given to five patients, three of whom had had relapse. Five patients healed without treatment. The relapses occurred only in old and prostrated patients. They often recurred several times in the same patient. 0.5 g of fusidic acid daily appears to be as effective as vancomycin and metronidazole for the treatment of C. difficile-induced colitis.
Infection
PMID:Fusidic acid for the treatment of antibiotic-associated colitis induced by Clostridium difficile. 649 Jan 73

Penicillin G administered parenterally or penicillin V administered orally are currently the antibiotics of choice for treatment of dental infections of usual etiology. Infections caused by penicillinase-producing staphylococci or those involving gram-negative bacteria should be treated with a penicillinase-resistant penicillin or an ampicillin-like derivative, respectively. Erythromycin is a second-choice bacteriostatic antibiotic, becoming first choice for treating dental infections in patients allergic to penicillin. The cephalosporins, similar in action to ampicillin-like penicillin derivatives, may be used with caution in patients who have exhibited delayed-type allergic reactions to penicillin and when erythromycin cannot be used. Their lack of advantage over other agents, and their cost, precludes routine use for usual dental infections. Clindamycin administered orally or lincomycin administered parenterally are reserve antibiotics indicated for treatment of bone infections and/or anaerobic infections refractory to commonly used antibiotics. Tetracyclines are, at best, third-choice agents for usual dental infections. However, they are useful for cases of acute necrotizing ulcerative gingivitis requiring systemic antibiotic therapy when penicillin is precluded. Vancomycin and streptomycin are used prophylactically for prevention of infective endocarditis in patients with prosthetic heart valves. Nystatin remains a first-choice agent for treatment of oral candidal infections. Ketoconazole, an orally active systemic antifungal agent, may be used for monilial infections of the oral cavity refractory to nystatin. Chemotherapy of viral infections is difficult because of the timing of events of the disease process versus appearance of clinical symptoms and lack of effective agents with selective toxicity. Herpes infections of the oral cavity have been treated--with limited success--with idoxuridine. Acyclovir, a newer antiviral drug, offers little clinical benefit for herpes infections in usually healthy patients but may be of value for treating such infections in immunocompromised patients. All antimicrobial agents may cause adverse reactions of varying degrees of severity. Most orally administered antibiotics may cause gastrointestinal disturbances. Superinfections occur with broad-spectrum antibiotics and a severe form of superinfection, antibiotic-associated colitis, has occurred with almost all antibiotics. Allergic reactions of all degrees of severity can occur with most antibiotics. The penicillins, followed by the cephalosporins and tetracyclines, are most frequently implicated in these reactions.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Use of antibiotics in dental practice. 658 79

A patient had common variable immunodeficiency, chronic malabsorption, and Campylobacter jejuni infection. Infection was diagnosed by jejunal aspiration. A follow-up jejunal aspirate was culture positive at the same time that a stool culture was negative. Infection resulted in worsening of chronic diarrhea, but it was not associated with clinical features of colitis or proctitis. The duration of infection was prolonged and initial antimicrobial therapy was ineffective. Single drug therapy with erythromycin ethylsuccinate and then chloramphenicol led to the emergence of resistant organisms. After five months of bacterial excretion, combination therapy with metronidazole and neomycin sulfate eliminated the organism. This case emphasizes that the clinical manifestations and response to therapy of C jejuni infection can be altered in immunodeficient patients.
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PMID:Jejunal infection with Campylobacter. 671 98

C. difficile, a gram-positive anaerobic bacillus, has emerged in the past five years as a common cause of hospital-acquired diarrhea. The organism usually gains entry to the host during or after antibiotic treatment, which presumably alters the normal barrier function of the colonic microflora. The organism produces a cytotoxin that can be identified in stool samples by its ability to alter the cellular morphology of tissue culture cells. Infection with C. difficile produces a spectrum of diseases ranging from mild diarrhea to fulminating colitis. An important bedside clue is the presence of pseudomembranes in the rectum or sigmoid at proctosigmoidoscopy. The disease may also occur in patients with chronic inflammatory bowel disease where it may be confused with a relapse of the underlying disease. Treatment with vancomycin is effective, but 10% to 15% of patients may experience relapse. The major mode of transmission appears to be environmental acquisition rather than person-to-person spread.
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PMID:Diarrhea we can treat: antibiotic-associated colitis. 712 40

Thirty patients with antimicrobial agent-associated pseudomembranous colitis (PMC) were studied for the presence of Clostridium difficile and its cytotoxin in feces. Either colonoscopy or barium enema radiography was required in three patients for the diagnosis of PMC because of nondiagnostic findings at sigmoidoscopy. Both the organism and cytotoxin were detected in 27 of the 30 patients; Staphylococcus aureus was excluded as the cause of PMC in two of the remaining patients. Eighteen of 19 patients with C. difficile-induced PMC who were treated with oral vancomycin had a salutary response; seven patients, however, had a relapse of colitis following the discontinuation of vancomycin. In general, relapses of colitis responded to retreatment with vancomycin. The implication of C. difficile as a cause of diarrhea is best achieved by the demonstration of colonic mucosal plaques or of a pseudomembrane. The value of fecal culture for C. difficile and cytotoxin assay is limited by the existence of asymptomatic carriers.
Infection 1982
PMID:Clostridium difficile and cytotoxin in feces of patients with antimicrobial agent-associated pseudomembranous colitis. 712 42

41 children were subjected to re-laparotomy because of obstruction after appendectomy. The causes were entero-colitis, occlusive ileus, rupture of the bowel and suture insufficiency. In this paper we report 6 children who had none of these complications. In these 6 children a "5-day syndrome" consisted usually of a fatal outcome with severe general peritonitis without a leakage of the appendix stump. Infection caused the endogenous spread of Bacteroides, following paralytic ileus and septicaemia. Early therapy with antibiotics and eventual re-laparotomy is then necessary.
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PMID:[The syndrome of the fifth postoperative day after appendicectomy (author's transl)]. 745 78


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