Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0008489 (chorea)
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Human Gene/Protein
GNAO1 protein 13.9
VPS13A 12.9
regulator of G-protein signalling 9 11.9
XK protein 11.9
RTN4IP1 11.6
CAG repeat containing 11.6
McLeod syndrome 11.6
chorea acanthocytosis 11.4
CHAC 11.0
JPH3 10.9
SFTA3 10.9
SCA17 10.8
ATP8A2 10.8
GNAO1 10.8
VPS13D 10.7
HLA-B49 10.6
CRMP5 10.3
Fibrillin 1 10.2
Galpha14 10.1
DRPLA 10.1
APTX 10.0
Kell protein 9.9
Kell blood group 9.8
SUCLG2 9.7
CLCN3 9.6
GPR88 9.6
AARS2 9.6
pantothenate kinase 9.5
ferritin light chain 9.4
PRR2 9.4
SLC18A1 9.4
SCA8 9.4
SCA10 9.3
VPS13C 9.1
LGI1 9.1
SUCLA2 9.1
phosphodiesterase 10A 9.0
dentatorubral-pallidoluysian atrophy 9.0
ADCK3 9.0
PNKP 9.0
CV2 8.9
NKX2.1 8.9
PKAN 8.9
CDC50A 8.9
small nuclear ribonucleoprotein polypeptide N 8.9
OPA3 8.8
FTL 8.8
jerky 8.8
Hallervorden-Spatz syndrome 8.8
PRRT2 8.7
Caspr2 8.7
NHE5 8.6
huntingtin 8.6
SUCLG1 8.6
thyroid transcription factor 1 8.5
GPR101 8.5
pristanoyl-CoA oxidase 8.5
DYT11 8.5
DPPX 8.5
SCA12 8.5
SCA7 8.5
CHMP2B 8.4
SCA1 8.4
D3nf 8.4
GPR50 8.3
puratrophin-1 8.3
ATP1A3 8.3
HTT 8.3
atrophin-1 8.2
Huntingtin 8.1
VAP-A 8.1
NK-2 8.1
SCA2 8.1
TEBP 8.0
HLA DQA1 8.0
aprataxin 8.0
ALS4 8.0
B37 7.9
SCA3 7.9
GPR3 7.9
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Disease
Chorea Syndrome 13.9
Senile chorea 13.9
degenerative chorea 13.9
Chronic Motor or Vocal Tic Disorder 13.9
Erythema marginatum 13.6
Chorea gravidarum 13.4
chronic chorea 12.9
Late onset Huntington's disease 12.9
Sydenham's chorea 12.9
hereditary chorea 12.9
progressive chorea 12.7
Dentatorubropallidoluysian atrophy 12.6
acanthocytosis 12.4
Drug-induced dyskinesia 12.3
Transient tic disorder 12.3
hemichorea 12.2
McLeod syndrome 11.9
Kozhevnikov's epilepsy 11.9
SCA18 11.9
SCA25 11.6
torsion spasm 11.6
Migratory polyarthritis 11.6
SCA20 11.6
Severe childhood autosomal recessive muscular dystrophy 11.6
moria 11.3
streptoccocal 11.3
CAPOS 11.2
MS-like syndrome 11.1
carditis 10.9
Vertical gaze palsy 10.9
Morvan 10.8
SCA17 10.8
Neuroleptic-induced tardive dyskinesia 10.7
PNKD 10.7
emotional outburst 10.6
Primary antiphospholipid syndrome 10.5
migratory arthritis 10.4
Cortical laminar necrosis 10.3
Parkinson's disease and parkinsonism 10.2
Orofacial dyskinesia 10.2
Acute rheumatic fever 10.1
rheumatic fever 10.1
choreoathetosis 10.0
movement disorder 9.7
Bretonneau 9.7
CHAC 9.7
MGA3 9.7
OPA3 9.6
SCA28 9.6
throat infection 9.6
SCA8 9.6
SCA4 9.5
acute rheumatic carditis 9.5
streptococcal infection 9.5
Axonal Neuropathy 9.4
Huntington's disease 9.4
Extrapontine myelinolysis 9.4
Carbohydrate-deficient glycoprotein syndrome 9.4
Mulvihill-Smith syndrome 9.4
Sandifer syndrome 9.4
abnormal involuntary movements 9.3
Dystonia 9.3
Neuropsychiatric lupus 9.3
adult HD 9.2
basal ganglia disease 9.2
Pontocerebellar hypoplasia 9.1
Fahr's disease 9.1
AOA2 9.0
valvulitis 9.0
dyskinesia 8.7
HDL1 8.7
DYT11 8.6
torsion dystonia 8.6
nervous system cancer 8.6
Speech impairment 8.5
SCA12 8.5
spasmus nutans 8.5
SCA7 8.5
Kluver-Bucy syndrome 8.5
transcortical aphasia 8.5
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Symptom
chorea 13.9
posthemiplegic chorea 12.9
Ballismus 12.9
Posturing 12.3
athetosis 11.9
abnormal head movement 11.9
Limb ataxia 10.7
Hemiballism 10.6
Negative myoclonus 10.4
dystonia 9.6
Involuntary Movement 9.4
dyslalia 9.4
asterixis 9.3
Pyramidal signs 9.3
myoclonus 9.2
Postural tremor 8.7
livedo 8.5
Parkinsonian tremor 8.5
motor symptom 8.5
carpopedal spasm 8.4
bradykinesia 8.4
hemihypesthesia 8.3
cerebellar ataxia 7.8
Ataxic 7.8
dysarthria 7.7
Kayser-Fleischer ring 7.7
abnormal gait 7.7
ataxic gait 7.6
delayed language development 7.5
Decreased activity 7.4
tremor 7.4
Crawling 7.3
blepharospasm 7.2
incoordination 7.2
Psychiatric symptoms 7.1
clumsiness 7.1
intention tremor 7.0
ataxia 7.0
astasia 7.0
Joint hypermobility 6.9
ketonuria 6.8
personality change 6.8
hypotonia 6.7
torticollis 6.6
drooling 6.5
Spastic 6.4
Neurologic symptoms 6.4
catarrh 6.3
Extrapyramidal symptoms 6.3
generalized pain 6.3
labored breathing 6.2
spasticity 6.0
aphonia 5.9
apathy 5.9
lightheadedness 5.9
consciousness disturbance 5.8
visual hallucination 5.7
ophthalmoplegia 5.5
testicular pain 5.5
muscle rigidity 5.4
hemiplegia 5.4
loss of balance 5.1
erythema 5.0
hyperemesis gravidarum 4.8
sore throat 4.8
arthralgia 4.8
seizures 4.7
excessive sweating 4.7
insomnia 4.7
neck stiffness 4.6
tonic-clonic seizure 4.5
limb pain 4.5
forgetfulness 4.5
paraparesis 4.5
agitation 4.4
memory loss 4.4
muscle cramps 4.1
regurgitation 4.1
neurological disability 4.0
polyuria 3.9
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Drug
Tiapride hydrochloride 13.9
Keppra 8.8
Flibanserin 8.5
Nabilone 8.2
Sinemet 8.1
Sinemet 8.0
Ovulen 7.3
Perphenazine 7.2
Paliperidone 7.1
Madopar 7.0
Fluphenazine 7.0
Proglumide 7.0
Sinemet 6.8
Lisuride 6.8
Adderall 6.6
Dilantin 6.6
Carbidopa 6.5
BOTOX 6.5
Premarin 5.6
Sodium valproate 5.6
Piracetam 5.4
Prednisone 4.9
Orphan 4.8
CFT 4.7
Sulpiride 4.7
DPA 4.6
Kainic acid 4.5
Rutin 4.5
Phenytoin 4.5
Estrogens 4.3
DBS 4.1
Gastro 4.1
Reserpine 3.9
Frontal 3.9
Infliximab 3.7
Infliximab 3.7
HCH 3.7
Apomorphine 3.6
Scopolamine 3.5
CTA 3.4
Prednisolone 3.4
DM1 3.3
Diurnal 3.1
CSF 3.1
Dakar 2.8
TMS 2.7
Vitamin E 2.2
Atropine 2.2
Retinoic acid 2.2
Spectrum 1.9
Glutathione 1.5
caffeine 1.5
Histamine 1.4
vitamin E 1.4
PTH 1.2
EPA 1.1
ROC 1.0
Spectrum 0.9
ENT 0.8
CTX 0.6
lysine -0.4
Dermatol -2.5
Cardiovasc -3.7
Enzyme
pantothenate kinase 9.5
sepiapterin reductase 6.4
alanyl-tRNA synthetase 6.1
Protein 2 5.1
glycine decarboxylase 4.7
GTP cyclohydrolase I 4.5
deoxyribonuclease 4.4
deoxyribonuclease 4.3
cGMP phosphodiesterase 4.0
ceruloplasmin 3.9
creatine kinase 3.9
hypoxanthine-guanine phosphoribosyltransferase 3.6
succinate dehydrogenase 3.5
Alternating 3.3
tyrosine hydroxylase 3.2
MPP 3.0
BAL 2.9
choline acetyltransferase 2.8
NADH dehydrogenase 2.8
phosphoglycerate kinase 2.8
cytochrome oxidase 2.8
ADH 2.8
citrate synthase 2.8
transglutaminase 2.6
histone acetyltransferase 2.5
STR 2.3
thromboplastin 2.2
GSK 2.2
DNase 2.0
complex I 1.8
alpha-amylase 1.5
monoamine oxidase 1.5
diaphorase 1.4
caspase-1 1.3
glucose-6-phosphate dehydrogenase 1.0
APC 0.9
calcineurin 0.8
caspase-3 0.8
alcohol dehydrogenase 0.7
phosphodiesterase 0.7
acetylcholinesterase 0.7
cholinesterase 0.3
DNA polymerase -0.2
catalase -0.3
endonuclease -0.3
superoxide dismutase -0.4
ATPase -0.5
glutathione peroxidase -0.5
protein kinase -0.8
proteasome -0.9
lactate dehydrogenase -0.9
peroxidase -1.1
trypsin -1.5
focal adhesion kinase -1.5
ERK -1.7
mitogen-activated protein kinase -1.7
protein kinase C -1.7
Compound
Oxiperomide 12.3
Tetrabenazine 11.3
Benzathine 9.8
Hydroxyamphetamine 9.5
Trihexyphenidyl 7.9
Benztropine 7.9
Choline chloride 7.8
Maneb 7.7
Succinyl-CoA 7.6
IDPN 7.5
DMAE 7.3
Fluphenazine 7.0
ASK 7.0
Amantadine 6.8
CAA 6.7
BayK8644 6.6
Pergolide 6.6
Tiagabine 6.6
Amantadine 6.5
Amantadine 6.5
BHC 6.4
Quinolinic acid 6.4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6.3
Filipin 6.3
Arecoline 6.2
Rivastigmine 6.2
Tetramethylpyrazine 6.2
Haloperidol 6.1
Amantadine 6.1
MPTP 6.1
Clonazepam 6.1
1,2,3,6-tetrahydropyridine 6.0
1,2,3,6-tetrahydropyridine 6.0
Haloperidol 6.0
PAPS 5.9
Levetiracetam 5.9
Pantothenate 5.8
TBP 5.8
L-DOPA 5.7
Levofloxacin 5.7
PZC 5.6
BNP 5.6
Premarin 5.6
TBP 5.6
Valproic acid 5.5
Pimozide 5.5
Metoclopramide 5.4
Baclofen 5.2
Riluzole 5.2
APS 5.1
HVA 5.1
d-Amphetamine 5.1
Phencyclidine 5.1
Procaine 5.0
Valproic acid 5.0
Picrotoxin 4.9
Picrotoxin 4.9
Sphingomyelin 4.9
Bromocriptine 4.8
Aripiprazole 4.8
Ondansetron 4.8
3-hydroxybutyric acid 4.7
Dopa 4.7
coenzyme Q10 4.7
Topiramate 4.7
Memantine 4.6
DPH 4.6
Ach 4.6
Kainic acid 4.5
Kainic acid 4.5
Tramadol 4.5
Guanine 4.4
Adenine 4.4
Prednisone 4.2
Muscimol 4.2
IPA 4.2
AEA 4.2
IPA 4.2
IPA 4.2
HMM 4.2
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