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Query: UMLS:C0008489 (chorea)
 2,102 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A wide variety of movement disorders are associated with alcohol abuse. Some idiopathic movement disorders are markedly improved by small amounts of alcohol and this response occasionally may lead to alcoholism. Alcohol abuse alone or combined with hepatic encephalopathy can cause various types of tremor, asterixis, and cerebellar dysfunction. Alcohol withdrawal is occasionally complicated by transient basal ganglia dysfunction manifested by parkinsonism or chorea. These syndromes are distinct from the movement disorders complicating acquired hepatolenticular degeneration occurring in some chronic alcoholics. This review discusses the clinical and pathophysiologic aspects of the movement disorder syndromes that complicate alcohol abuse.
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PMID:Movement disorders in alcoholism: a review. 201 Dec 71

We report on a female inpatient who at the age of 47 years presented depressive and anxiety symptoms and alcohol abuse and who suffered from cognitive, personality, and discrete movement disturbances later on. In the course of the long-term psychotherapy which was supported by the technique of creative drawings previously forgotten memories of a very severe sexual abuse in childhood emerged. The recovery of these memories was followed by an intensification of the anxiety which lead to several psychiatric rehospitalizations. During the last hospital stay the diagnosis of Huntington's chorea was verified explaining well the rich psychopathology of the patient. The recollections of sexual abuse were for the most part qualified as a false memory syndrome. In addition to other factors the chorea-inherent cognitive impairment will have contributed to the occurrence of false memory syndrome. The new diagnosis dictated a change of the therapeutic procedure which, at least in the medium-term, proved to be successful.
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PMID:[Child sexual abuse, false-memory syndrome and Huntington chorea]. 1052 55

Many movement disorders, including tics, chorea, tremor, myoclonus and parkinsonism, may result from substance abuse. However, alcohol in particular is associated in a more complex manner with two specific movement disorders, essential tremor (ET) and myoclonus-dystonia (M-D). In this review we discuss the comorbidity of alcohol abuse in both ET and M-D, the ameliorative effects of alcohol in both diseases, and review the data evaluating alcohol abuse secondary to self-medication. We also discuss shared pathophysiologic mechanisms in the understanding of both of these disorders, as the elucidation of the mechanisms by which alcohol exerts its effects may lead to novel therapeutic approaches.
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PMID:Movement disorders and alcohol misuse. 1680 Aug 24

Chorea is uncommonly caused by toxins. Anecdotal evidence from cases of toxin-induced chorea assists in our understanding of neurodegenerative diseases associated with chorea. Beginning in medieval Europe with ergotism and the "fire that twisted people," spanning to crack dancing in contemporary times and the coexistence of alcohol abuse with chorea, toxins may exert direct effects to enhance mesolimbic dopamine transmission or indirect effects through gamma-aminobutyric acid modulation. The following chapter will discuss toxins associated with chorea and the presumed pathophysiology underlying the movement disorders in these case series.
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PMID:Chorea caused by toxins. 2149 93