Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0008489 (chorea)
 2,102 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During a 5-year period ending in December 1989, 73 episodes of acute rheumatic fever in 67 children aged 4-14 years were prospectively studied to ascertain the clinical profile of the disease in initial attacks and recurrences, and to compare the findings with those from other countries. Among 51 children with a first episode of acute rheumatic fever, 76% had arthritis and 43% had carditis. In 22 children with recurrences, arthritis was present in 45% and carditis in 91%. Carditis was more severe among the cases with recurrences. Mitral insufficiency was the most common valvular lesion, but no case of mitral stenosis was detected. Chorea, subcutaneous nodules, and Erythema marginatum were relatively rare. The demographic, clinical and laboratory findings of this study resemble those from Western countries, in contrast with data from tropical countries. Efforts aimed at prompt recognition and adequate treatment of streptococcal pharyngitis and maintenance of anti-streptococcal chemoprophylaxis would be rewarding in reducing the incidence of this disease and its sequelae.
 ...
PMID:Acute rheumatic fever during childhood in Saudi Arabia. 171 21

Clinical profile of rheumatic fever (RF) in 100 hospitalised children of Bangladesh were studied. Peak age period of the incidence of the disease was found in the age group of 11-12 years (34 percent) and majority (83.5 percent) of the cases belonged to the middle and poor classes. There was slight preponderance of the male. Carditis was the commonest (64 percent) manifestation followed by poly-arthritis (51 percent). Chorea was present in 6 percent and subcutaneous nodules were in 7 percent cases. Erythema marginatum (EM) was conspicuous by its absence. Amongst the rheumatic heart diseases (RHD), mitral stenosis (MS) and mitral incompetence (MI) comprised the highest (35 percent) incidence and next to it was the MS (13 percent) and MI (9 percent).
 ...
PMID:Clinical profile of rheumatic fever in some hospitalised children of Bangladesh. 402 60

The clinical profile of acute rheumatic fever below the age of five years was studied prospectively in 53 children seen over a period of seven years. The majority presented with pain in the joints, manifested as arthritis in 81% and arthralgia in 15%. Four per cent presented with congestive heart failure. Carditis developed in 42%, with a high incidence of pericarditis (6%) and congestive heart failure (15%) and a mortality of 2%. The incidence of Erythema marginatum was 2%, while chorea and subcutaneous nodules were not seen. Data from this prospective study, when compared with those of other prospective studies of acute rheumatic fever throughout childhood, clearly show a similar incidence of arthritis and carditis with a slightly more aggressive nature of carditis in children under five years. These findings are in marked contrast to recent reports describing the clinical profile of acute rheumatic fever in this age group.
 ...
PMID:Acute rheumatic fever below the age of five years: a prospective study of the clinical profile. 620 72

We designed a multi-hospital prospective study of children less than 12 years to determine the comparative clinical profile, severity of carditis, and outcome on follow up of patients suffering an initial and recurrent episodes of acute rheumatic fever. The study extended over a period of 3 years, with diagnosis based on the Jones criteria. We included 161 children in the study, 57 having only one episode and 104 with recurrent episodes. Those seen in the first episode were differentiated from those with recurrent episodes on the basis of the history. The severity of carditis was graded by clinical and echocardiographic means. In those suffering their first episode, carditis was significantly less frequent (61.4%) compared to those having recurrent episodes (96.2%). Arthritis was more marked in the first episode (61.4%) compared to recurrent episodes (36.5%). Chorea was also significantly higher in the first episode (15.8%) compared to recurrent episodes (3.8%). Sub-cutaneous nodules were more-or-less the same in those suffering the first (7%) as opposed to recurrent episodes (5.8%), but Erythema marginatum was more marked during the first episode (3.5%), being rare in recurrent episodes at 0.9%. Fever was recorded in approximately the same numbers in first (45.6%) and recurrent episodes (48.1%). Arthralgia, in contrast, was less frequent in first (21.1%) compared to recurrent episodes (32.7%). A history of sore throat was significantly increased amongst those suffering the first episode (54.4%) compared to recurrent episodes (21.2%). When we compared the severity of carditis in the first versus recurrent episodes, at the start of study mild carditis was found in 29.8% versus 10.6%, moderate carditis in 26.3% versus 53.8%, and severe carditis in 5.3% versus 31.8% of cases, respectively. At the end of study, 30.3% of patients suffering their first episode were completely cured of carditis, and all others showed significant improvement compared to those with recurrent episodes, where only 6.8% were cured, little improvement or deterioration being noted in the remainder of the patients. We conclude that the clinical profile of acute rheumatic fever, especially that of carditis, is milder in those suffering their first attack compared to those with recurrent episodes.
 ...
PMID:Clinical profile of acute rheumatic fever in Pakistan. 1269 Dec 85