Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0008370 (cholestasis)
9,378 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein alkaline phosphatase 657 Sep 580 alanine aminotransferase 250 bile salt export pump 217 Mol 210 aspartate aminotransferase 210 albumin 165 ICP 160 farnesoid X receptor 139 ABCB11 133 collagen 128 She 124 Alagille syndrome 122 BSEP 121 gamma-glutamyl transpeptidase 110 ATP 110 endoplasmic reticulum 99 gut 96 microsomal 95 cytokine 94 AST 89 polypeptide 86 ABCB4 84 nuclear receptor 82 insulin 80 gamma-glutamyltransferase 78 citrin 76 GSH 76 prothrombin 74 FXR 71 ATPase 68 cytochrome P450 64 MDR3 64 lactate dehydrogenase 58 multidrug resistance-associated protein 57 MRP2 55 SLC25A13 53 tumor necrosis factor 50 ALP 48 catalase 46 GGT 46 gamma-glutamyltranspeptidase 46 TNF 45 CYP7A1 43 pregnane X receptor 43 lipopolysaccharide 42 HDL 42 NTCP 42 xenobiotic 42 serum albumin 42 GTG 41 IL-6 40 SHP 40 hemoglobin 38 ATP-binding cassette 37 Pol 37 superoxide dismutase 37 caspase-3 36 IgA 36 P-glycoprotein 36 PBC 35 interferon 35 cytochrome P-450 33 Citrin 33 multidrug resistance protein 2 33 VPS33B 32 secretin 31 MRP3 30 MDR2 30 5'-nucleotidase 30 LPS 30 alpha 1-antitrypsin 30 alpha-1-antitrypsin 29 constitutive androstane receptor 29 glucagon 28 HLA 28 Alkaline phosphatase 28 peroxidase 28 TPN 28 reductase 28 more...

Disease cholestasis 9378 liver disease 1276 cirrhosis 1052 hepatitis 825 pruritus 702 cholangitis 627 primary biliary cirrhosis 532 biliary atresia 381 cancer 363 biliary obstruction 343 gallstones 301 obstructive jaundice 289 sepsis 285 primary sclerosing cholangitis 284 sepsis 272 tumor 272 hyperbilirubinemia 261 viral hepatitis 236 pancreatitis 215 liver fibrosis 211 portal hypertension 211 hepatocellular carcinoma 201 chronic liver disease 199 fatty liver 190 chronic hepatitis 185 acute hepatitis 153 carcinoma 153 diabetes 148 chronic pancreatitis 123 choledocholithiasis 105 cytomegalovirus 104 hepatitis B 102 malabsorption 102 chronic active hepatitis 102 cystic fibrosis 97 ischemia 90 hepatitis C 89 anemia 87 virus infection 86 cholecystitis 85 hepatitis A 78 acute pancreatitis 76 GSH 76 ICP 74 renal failure 74 pancreatic cancer 74 hypercholesterolemia 73 hypertension 72 metastases 70 preeclampsia 68 dysplasia 67 renal disease 65 thrombocytopenia 64 Intrahepatic cholestasis 64 malnutrition 63 coagulopathy 61 hypoglycemia 60 rash 60 inflammatory bowel disease 58 HIV 58 encephalopathy 58 Wilson's disease 56 obesity 55 sarcoidosis 53 graft-versus-host disease 52 failure to thrive 52 osteoporosis 52 prematurity 49 AIDS 48 autoimmune disease 48 infectious diseases 47 Hodgkin's disease 47 hyperlipidemia 47 ulcerative colitis 46 NAME 46 esophageal varices 44 citrullinemia 43 acute cholecystitis 43 short bowel syndrome 43 amyloidosis 42 more...

Symptom abdominal pain 195 hepatomegaly 175 pain 138 fatigue 100 diarrhea 100 vomiting 86 splenomegaly 69 hepatosplenomegaly 59 anorexia 49 anesthesia 46 nausea 43 hyperemesis gravidarum 30 dark urine 29 seizures 25 Ill 24 respiratory distress 24 regurgitation 24 weakness 20 epigastric pain 19 hypotonia 18 asthenia 18 collapse 18 lethargy 15 cough 15 right upper quadrant pain 15 ataxia 14 discomfort 13 dyspnea 12 analgesia 12 discomfort 12 headache 11 hypoproteinemia 11 arthralgia 11 abdominal discomfort 11 chills 11 starvation 10 cachexia 10 ophthalmoplegia 9 overweight 8 nausea and vomiting 8 polydipsia 7 polyuria 7 colic 7 acute abdominal pain 6 erythema 6 spasm 6 back pain 6 exhaustion 5 chest pain 5 Generalized pruritus 5 fever of unknown origin 5 constipation 5 sore throat 5 sleepiness 5 hypothermia 5 agitation 4 flushing 4 myalgia 4 tremor 4 insomnia 4 jaundice of the skin 4 oliguria 4 cerebellar ataxia 3 Decreased activity 3 Upper abdominal pain 3 dystonia 3 pallor 3 bone pain 3 dysarthria 3 impaired motor coordination 3 dry eye 3 intestinal bleeding 3 wheezing 3 acute abdomen 3 functional recovery 2 abdominal cramps 2 paraparesis 2 tense 2 anosmia 2 night sweats 2 more...

Drug vitamin E 60 Dermatol 52 Portal 33 PTC 20 NADH 19 ABC 15 lactose 14 EE2 13 ampicillin 11 lysine 11 Vitamin K 11 ROS 11 ascorbate 10 Cardiovasc 10 Vitamin E 10 Estrogens 9 Monit 9 Troglitazone 9 Amoxicillin 8 Leaf 8 caffeine 8 MAP 8 Glutathione 7 Ethanol 7 Secretin 7 Neoral 6 Albumin 6 AMC 6 DMAP 5 Augmentin 5 Tacrolimus 5 Augmentin 5 Dial 5 IL-2 5 Prednisolone 5 Gel 5 Bezafibrate 4 Adriamycin 4 ENT 4 Fraction 4 Cremophor EL 4 Adenosine triphosphate 4 ALA 4 Dakar 4 Photofrin 3 Nimesulide 3 Soybean oil 3 Kenyan 3 Alanine 3 Meconium 3 ICI 3 Emodin 3 Indomethacin 3 Etoposide 3 Emodin 3 Prednisone 3 Vitamin B12 3 niacin 3 IFN-gamma 2 Swertia 2 Fructose 2 ETA 2 Rituximab 2 Bosentan 2 Meropenem 2 Diurnal 2 Heme 2 Mesalazine 2 DNase I 2 Zileuton 2 Nephron 2 Ranitidine 2 Bifidobacterium 2 uPA 2 Infliximab 2 Meropenem 2 Mutagen 2 Iodipamide 2 CCL 2 PCB 2 more...

Enzyme alkaline phosphatase 658 alanine aminotransferase 426 gamma-glutamyl transpeptidase 349 aspartate aminotransferase 302 AST 89 ATPase 77 lactate dehydrogenase 65 catalase 52 peroxidase 50 superoxide dismutase 44 mitogen-activated protein kinase 43 CYP7A1 38 P-glycoprotein 37 5'-nucleotidase 30 glutathione peroxidase 27 UDP-glucuronosyltransferase 25 protein kinase C 24 transpeptidase 24 caspase-3 22 luciferase 22 Mg2+-ATPase 22 cholinesterase 22 protein kinase 21 lipase 20 CYP3A4 19 ERK 18 ceruloplasmin 18 glutathione S-transferase 17 acetylcholinesterase 16 leucine aminopeptidase 15 reverse transcriptase 14 lecithin:cholesterol acyltransferase 14 cholesterol acyltransferase 14 beta-glucuronidase 13 pyruvate dehydrogenase 13 AMP-activated protein kinase 13 CYP27A1 12 trypsin 12 acid phosphatase 12 hexosaminidase 11 sorbitol dehydrogenase 11 demethylase 11 NO synthase 11 CPR 10 proteasome 10 NOS 10 renin 10 ferrochelatase 10 glutathione reductase 10 nucleotidase 10 glucose-6-phosphate dehydrogenase 9 glutamate dehydrogenase 9 arginase 9 caspase-8 9 MEK 9 CYP8B1 9 glutamate dehydrogenase 9 glutamate dehydrogenase 9 heme oxygenase 8 argininosuccinate synthetase 8 collagenase 8 xanthine oxidase 8 gamma-glutamylcysteine synthetase 8 calcineurin 8 focal adhesion kinase 7 AMPK 7 phosphodiesterase 7 glutamine synthetase 7 NADPH oxidase 7 urokinase-type plasminogen activator 7 thromboplastin 7 diaphorase 7 NQO1 7 elastase 6 aldehyde dehydrogenase 6 NADPH oxidase 6 succinate dehydrogenase 6 creatine kinase 6 glucose-6-phosphatase 6 AMPK 6 more...

Compound Clin 987 Dec 565 salt 312 sodium 239 DNA 182 Ursodeoxycholic acid 153 glucose 147 calcium 139 water 128 copper 125 ATP 110 oxygen 90 GSH 81 GSH 81 iron 77 sulfate 72 methionine 70 nitric oxide 67 Estrogen 63 creatinine 59 urea 58 ethanol 58 arginine 57 Parenteral 55 acetate 55 His 53 vitamin D 53 alanine 52 phosphate 49 ALP 48 TNF 45 galactose 42 ANI 42 manganese 37 nitrogen 37 cAMP 36 adenosylmethionine 35 CCl4 34 Cyclosporine 33 ammonia 33 NADP 30 zinc 29 Cholesterol 28 Bilirubin 27 potassium 26 cysteine 25 tyrosine 25 Lithocholic acid 23 glutamate 23 GPT 23 GSSG 22 FK506 21 Rifampicin 21 Taurocholate 21 Chenodeoxycholic acid 20 NADH 19 APAP 19 glutamine 18 IDA 18 Tauroursodeoxycholic acid 18 MDA 17 Chlorpromazine 17 Cholic acid 17 phosphorus 17 serine 17 NADPH 16 NADPH 16 iodine 16 Estradiol 16 Melatonin 15 Luminal 15 aluminum 15 Sodium 15 retinol 14 carbonate 14 ADP 14 Taurine 14 UDP 14 ammonium 14 nitrate 13 more...

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