Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0008370 (cholestasis)
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Human Gene/Protein
mitochondrial aspartate-glutamate carrier protein 11.7
TBC1D3C 11.7
Lst-1 11.7
PFIC 11.4
USP53 11.1
VPS33B 11.1
mitochondrial solute carrier protein 11.0
Citrin 11.0
ABCB11 10.8
sodium/bile acid cotransporter 10.7
C14orf133 10.7
ITFG2 10.7
SLC25A13 10.7
multidrug resistance protein 3 10.6
BSEP 10.5
ABCB4 protein 10.5
vacuolar protein sorting 33B 10.5
bile salt export pump 10.5
citrin 10.5
ATP8B2 10.4
ABCB4 10.4
myosin 5B 10.1
myosin VB 10.1
ATP8B4 10.1
MDR3 10.0
ATP8B3 9.9
BCS1 9.9
Alagille syndrome 9.9
Cirhin 9.9
MDR2 9.8
ST3GalV 9.7
IDH3G 9.7
BCS1L 9.7
TJP2 9.6
OSTalpha 9.4
hepatic nuclear factor 4 alpha 9.4
MRGPRX1 9.4
HIVEP1 9.4
GGT3 9.4
PDZD4 9.4
more...
Disease
Cholangitis lenta 11.7
Interstitial pancreatitis 11.7
Primary cholangitis 11.7
Neonatal conjugated hyperbilirubinemia 11.7
cholecystectasia 11.7
cholestasis 11.7
Conjugated bilirubinaemia 11.7
syndrome; viral 11.7
PFIC3 11.7
PFIC1 11.6
Benign recurrent intrahepatic cholestasis 11.5
PFIC2 11.4
Vanishing bile duct syndrome 11.4
Neonatal cholestasis 11.3
Intrahepatic cholestasis 11.1
Liver cholestasis 11.0
Extrahepatic cholestasis 10.9
NAIC 10.9
Cholestatic liver disease 10.8
hepatocholangitis 10.7
Cholestasis and jaundice 10.7
Drug-induced intrahepatic cholestasis 10.7
Hardikar syndrome 10.7
Early cirrhosis 10.7
Acute cholestatic hepatitis 10.7
Suppurative cholangitis 10.7
CTLN2 10.6
Conjugated hyperbilirubinemia 10.6
cholemia 10.6
cholangiolitis 10.5
Stauffer's syndrome 10.5
Cholestatic hepatitis 10.4
inspissated bile syndrome 10.3
Hepatic amyloidosis 10.1
Other liver diseases 10.1
Syncytial giant cell hepatitis 10.1
Gastrointestinal hypomotility 10.1
Bile duct stricture 10.1
Secondary biliary cirrhosis 10.1
Bacterial cholangitis 10.1
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Symptom
Hepatocellular jaundice 11.7
Bile pigment retention 11.7
Pruritus of pregnancy 11.1
Nasal discomfort 10.7
jaundice of the skin 9.7
Generalized pruritus 9.5
Courvoisier's sign 9.4
Upper abdominal pain 9.0
liver pain 8.7
Unexplained abdominal pain 8.6
dark urine 8.4
Musculoskeletal discomfort 7.9
hyperemesis gravidarum 7.5
Murphy's sign 6.8
Fetal bradycardia 6.7
Intermenstrual bleeding 6.7
hepatomegaly 6.7
right upper quadrant pain 6.2
stomach cramps 6.1
impaired motor coordination 5.7
painful swallowing 5.7
hepatosplenomegaly 5.5
generalized abdominal pain 5.1
hypoproteinemia 5.0
lassitude 4.6
generalized rash 4.6
splenomegaly 4.6
asthenia 4.5
hyperemesis 4.5
menometrorrhagia 4.4
abdominal discomfort 4.4
abdominal pain 4.4
Decreased activity 4.3
epigastric pain 4.2
Neurologic symptoms 4.2
abdominal cramps 3.7
intestinal bleeding 3.7
anorexia 3.6
polydipsia 3.4
loin pain 3.4
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Drug
Quetiapine hemifumarate 11.7
Nicomol 10.1
Sulfobromophthalein sodium 10.1
Propafenone hydrochloride 8.0
Iodipamide 7.9
Propafenone HCl 7.9
Colestimide 7.7
Cupric sulfate 7.7
cetrorelix acetate 7.6
Platelet concentrate 7.6
Mebrofenin 7.6
Naltrexone hydrochloride 7.5
CFDN 7.3
Sincalide 7.2
Mangafodipir trisodium 7.1
Xipamide 7.1
Sodium phenylbutyrate 6.9
Protein hydrolysate 6.9
Eldepryl 6.8
Nitisinone 6.8
Medicon 6.7
Eldepryl 6.6
Cefpiramide 6.6
Mercaptopurine 6.4
Cilastatin 6.3
Lariam 6.2
Zinc acetate 6.2
Soybean oil 6.0
Augmentin 6.0
Cerezyme 5.9
Augmentin 5.9
Lariam 5.9
Liposyn 5.9
Troglitazone 5.8
Nafcillin 5.8
Rhubarb 5.7
Temocillin 5.7
Fotemustine 5.7
Bezafibrate 5.6
Ceruletide 5.6
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Enzyme
sedoheptulokinase 9.4
CYP8B1 8.4
ganglioside galactosyltransferase 8.1
CYP7A1 7.0
gamma-glutamyl transpeptidase 7.0
5beta-reductase 6.5
CYP7B1 6.3
CYP27A1 6.2
porphobilinogenase 5.9
histidase 5.9
transpeptidase 5.8
alanine aminotransferase 5.8
Mg2+-ATPase 5.7
AST 5.6
aspartate aminotransferase 5.6
alkaline phosphatase 5.5
glycine N-methyltransferase 5.4
lecithin:cholesterol acyltransferase 5.3
argininosuccinate synthetase 5.3
ferrochelatase 5.2
isovaleryl-CoA dehydrogenase 5.2
sorbitol dehydrogenase 5.1
glycerol 3-phosphate dehydrogenase 5.1
dimethylarginine dimethylaminohydrolase 5.1
nucleotidase 5.0
5'-nucleotidase 5.0
leucine aminopeptidase 5.0
phosphatidylethanolamine N-methyltransferase 4.9
alpha-methylacyl-CoA racemase 4.9
alanine aminopeptidase 4.8
6beta-hydroxylase 4.7
UDP-glucuronosyltransferase 4.7
cholesterol acyltransferase 4.5
betaine-homocysteine methyltransferase 4.4
lecithin:retinol acyltransferase 4.4
type III procollagen 4.3
gamma-glutamylcysteine synthetase 4.2
TSR 4.2
3alpha-hydroxysteroid dehydrogenase 4.2
mevalonate kinase 4.1
more...
Compound
Dipropyl sulfide 10.7
Estradiol-17beta-glucuronide 10.7
Sulfolithocholylglycine 10.1
Glycolithocholic acid 10.1
Varanic acid 10.1
Bilirubin diglucuronide 9.9
Taurolithocholate 9.8
Ursodeoxycholic acid 9.7
Glycoursodeoxycholate 9.7
Glycochenodeoxycholic acid 9.7
Isoursodeoxycholic acid 9.7
Yangonin 9.7
Yangonin 9.5
GW 4064 9.4
Lithocholic acid 9.2
2-nonynoic acid 9.1
Glycodeoxycholate 9.1
Taurochenodeoxycholate 9.1
taurolithocholate 3-sulfate 9.0
6-ECDCA 8.9
TMCA 8.7
Di-n-butyltin dichloride 8.6
ANI 8.6
Sulfobromophthalein 8.6
TMCA 8.4
Chenodeoxycholic acid 8.3
Tauroursodeoxycholic acid 8.2
Midecamycin 8.1
Midecamycin 8.1
2-octynoic acid 8.1
1-bromoheptane 8.0
Taurocholate 7.9
cholan-24-oic acid 7.9
Harmol 7.8
Miroestrol 7.8
imidazo[2,1-b][1,3]thiazole-5-carbaldehyde 7.8
cholan-24-oic acid 7.8
Tolazamide 7.7
Thiobenzamide 7.7
Sporidesmin 7.6
more...