Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0008370 (cholestasis)
 9,378 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
alkaline phosphatase 657
Sep 580
alanine aminotransferase 250
bile salt export pump 217
Mol 210
aspartate aminotransferase 210
albumin 165
ICP 160
farnesoid X receptor 139
ABCB11 133
collagen 128
She 124
Alagille syndrome 122
BSEP 121
ATP 110
gamma-glutamyl transpeptidase 110
endoplasmic reticulum 99
gut 96
microsomal 95
cytokine 94
AST 89
polypeptide 86
ABCB4 84
nuclear receptor 82
insulin 80
gamma-glutamyltransferase 78
citrin 76
GSH 76
prothrombin 74
FXR 71
ATPase 68
cytochrome P450 64
MDR3 64
lactate dehydrogenase 58
multidrug resistance-associated protein 57
MRP2 55
SLC25A13 53
tumor necrosis factor 50
ALP 48
GGT 46
gamma-glutamyltranspeptidase 46
catalase 46
TNF 45
pregnane X receptor 43
CYP7A1 43
serum albumin 42
HDL 42
xenobiotic 42
NTCP 42
lipopolysaccharide 42
GTG 41
IL-6 40
SHP 40
hemoglobin 38
superoxide dismutase 37
ATP-binding cassette 37
Pol 37
P-glycoprotein 36
caspase-3 36
IgA 36
interferon 35
PBC 35
Citrin 33
cytochrome P-450 33
multidrug resistance protein 2 33
VPS33B 32
secretin 31
alpha 1-antitrypsin 30
MRP3 30
LPS 30
MDR2 30
5'-nucleotidase 30
constitutive androstane receptor 29
alpha-1-antitrypsin 29
Alkaline phosphatase 28
HLA 28
TPN 28
glucagon 28
reductase 28
peroxidase 28
TGR5 27
TNF-alpha 27
MRI 27
membrane-bound 27
PFIC 27
lymphoid 27
LDH 26
cholecystokinin 26
glutathione peroxidase 26
bone sialoprotein 25
JAG1 25
PXR 25
CD4 24
A-I 23
reserved 23
amylase 23
GPT 23
nitric oxide synthase 22
multidrug resistance protein 3 22
Farnesoid X receptor 22
C-reactive protein 22
NADH 21
Bcl-2 21
hemochromatosis 21
apoE 21
alpha-fetoprotein 21
glycoprotein 21
heme oxygenase-1 20
PTC 20
ACG 20
fibrinogen 20
ABCC2 20
proliferating cell nuclear antigen 19
interleukin-6 19
CYP3A4 19
organic anion transporting polypeptide 19
myeloperoxidase 19
CAR 18
multidrug resistance protein 18
IDA 18
growth hormone 17
CD8 17
inducible nitric oxide synthase 17
MRP4 17
p53 17
bile acid receptor 17
ABO 17
Fas 17
ABC transporter 17
smooth muscle actin 17
protoporphyria 17
prolactin 17
cytokeratin 17
ferritin 16
P450 16
Nrf2 16
NADPH 16
cytokeratin 19 16
tumor necrosis factor alpha 16
lipase 16
opioid receptor 16
ASBT 16
FGF19 15
cytochrome c 15
ZO-1 15
ABC 15
IFN 15
erythroid 15
glutamate carrier 15
ceruloplasmin 15
leucine aminopeptidase 14
somatostatin 14
LCAT 14
alpha-smooth muscle actin 14
Wilson disease 14
JNK 14
MDR1 14
caspase-8 14
chronic renal failure 14
SMA 14
more...
Disease
cholestasis 9378
liver disease 1276
cirrhosis 1052
hepatitis 825
pruritus 702
cholangitis 627
primary biliary cirrhosis 532
biliary atresia 381
cancer 363
biliary obstruction 343
gallstones 301
obstructive jaundice 289
sepsis 285
primary sclerosing cholangitis 284
sepsis 272
tumor 272
hyperbilirubinemia 261
viral hepatitis 236
pancreatitis 215
portal hypertension 211
liver fibrosis 211
hepatocellular carcinoma 201
chronic liver disease 199
fatty liver 190
chronic hepatitis 185
carcinoma 153
acute hepatitis 153
diabetes 148
chronic pancreatitis 123
choledocholithiasis 105
cytomegalovirus 104
chronic active hepatitis 102
malabsorption 102
hepatitis B 102
cystic fibrosis 97
ischemia 90
hepatitis C 89
anemia 87
virus infection 86
cholecystitis 85
hepatitis A 78
acute pancreatitis 76
GSH 76
pancreatic cancer 74
renal failure 74
ICP 74
hypercholesterolemia 73
hypertension 72
metastases 70
preeclampsia 68
dysplasia 67
renal disease 65
Intrahepatic cholestasis 64
thrombocytopenia 64
malnutrition 63
coagulopathy 61
rash 60
hypoglycemia 60
inflammatory bowel disease 58
HIV 58
encephalopathy 58
Wilson's disease 56
obesity 55
sarcoidosis 53
osteoporosis 52
failure to thrive 52
graft-versus-host disease 52
prematurity 49
AIDS 48
autoimmune disease 48
hyperlipidemia 47
Hodgkin's disease 47
infectious diseases 47
ulcerative colitis 46
NAME 46
esophageal varices 44
citrullinemia 43
short bowel syndrome 43
acute cholecystitis 43
amyloidosis 42
necrotizing enterocolitis 41
alcoholic hepatitis 41
tuberculosis 40
eosinophilia 40
alcoholic cirrhosis 40
hepatic encephalopathy 40
lymphoma 39
dyslipidemia 39
Budd-Chiari syndrome 39
alcoholism 38
peritonitis 38
vitamin K deficiency 38
adenocarcinoma 37
rare disease 37
carcinogenesis 36
sickle cell disease 36
erythropoietic protoporphyria 36
hyperthyroidism 35
lymphadenopathy 34
depression 34
alcoholic fatty liver 34
Crohn's disease 33
steatorrhea 33
hemolytic anemia 33
neonatal jaundice 33
CTLN2 33
hemochromatosis 32
Benign recurrent intrahepatic cholestasis 32
Dubin-Johnson syndrome 32
genetic disorder 32
liver cancer 31
Epstein 31
HELLP syndrome 31
immunodeficiency 30
SEM 30
cold 30
bone disease 30
pneumonia 30
biliary tract disease 29
cholecystolithiasis 29
bacterial infection 28
heart failure 28
heart disease 27
vitamin E deficiency 27
leukemia 26
Echinococcus 26
iron overload 26
rheumatoid arthritis 26
Hepatotoxicity 25
Extrahepatic cholestasis 25
adenoma 25
celiac disease 25
atherosclerosis 25
PFIC1 25
Gilbert 24
hypothyroidism 24
disseminated intravascular coagulation 24
Syndrome 23
PFIC2 23
hypovitaminosis 23
systemic lupus erythematosus 23
Best 23
Cholestatic liver disease 23
Vanishing bile duct syndrome 23
lactic acidosis 22
liver cancer 22
vasculitis 22
purpura 22
bile duct stenosis 22
alcohol abuse 22
Cirrhosis 21
Cholangiocarcinoma 21
multiple myeloma 21
Neonatal cholestasis 21
Infection 20
varices 20
papillary thyroid cancer 20
pancytopenia 20
pemphigoid 20
skin disease 20
more...
Symptom
abdominal pain 195
hepatomegaly 175
pain 138
diarrhea 100
fatigue 100
vomiting 86
splenomegaly 69
hepatosplenomegaly 59
anorexia 49
anesthesia 46
nausea 43
hyperemesis gravidarum 30
dark urine 29
seizures 25
regurgitation 24
respiratory distress 24
Ill 24
weakness 20
epigastric pain 19
hypotonia 18
collapse 18
asthenia 18
right upper quadrant pain 15
lethargy 15
cough 15
ataxia 14
discomfort 13
dyspnea 12
analgesia 12
discomfort 12
arthralgia 11
hypoproteinemia 11
chills 11
headache 11
abdominal discomfort 11
starvation 10
cachexia 10
ophthalmoplegia 9
nausea and vomiting 8
overweight 8
polydipsia 7
polyuria 7
colic 7
spasm 6
acute abdominal pain 6
erythema 6
back pain 6
chest pain 5
exhaustion 5
Generalized pruritus 5
constipation 5
sleepiness 5
sore throat 5
fever of unknown origin 5
hypothermia 5
jaundice of the skin 4
tremor 4
insomnia 4
flushing 4
agitation 4
myalgia 4
oliguria 4
bone pain 3
Upper abdominal pain 3
Decreased activity 3
pallor 3
intestinal bleeding 3
dysarthria 3
dystonia 3
impaired motor coordination 3
dry eye 3
cerebellar ataxia 3
wheezing 3
acute abdomen 3
abdominal cramps 2
decreased appetite 2
low back pain 2
tense 2
lassitude 2
cyanosis 2
anosmia 2
night sweats 2
hyperemesis 2
tachypnea 2
functional recovery 2
Pruritus of pregnancy 2
Murphy's sign 2
paraparesis 2
dry skin 2
ENT 1
microbial colonization 1
Nasal discomfort 1
Musculoskeletal discomfort 1
sneezing 1
leg pain 1
limb pain 1
arm pain 1
Intermenstrual bleeding 1
apathy 1
renal colic 1
shortness of breath 1
chorea 1
stomach pain 1
Gastrointestinal symptoms 1
retching 1
Courvoisier's sign 1
chronic constipation 1
angina 1
clubbing 1
liver pain 1
productive cough 1
Fetal bradycardia 1
myoclonus 1
dental pain 1
dizziness 1
Physical findings 1
HSA 1
emaciation 1
Fluctuation 1
enuresis 1
Hepatocellular jaundice 1
rundown 1
memory loss 1
flank pain 1
generalized abdominal pain 1
loin pain 1
Wind 1
Bile pigment retention 1
menometrorrhagia 1
hyperoxia 1
stomach cramps 1
stigma 1
heartburn 1
generalized rash 1
distraction 1
skin damage 1
chest tightness 1
pleuritic chest pain 1
Neurologic symptoms 1
rigors 1
thinning 1
cancer pain 1
Unexplained abdominal pain 1
hunger 1
painful swallowing 1
leg edema 1
Drug
vitamin E 60
Dermatol 52
Portal 33
PTC 20
NADH 19
ABC 15
lactose 14
EE2 13
Vitamin K 11
ampicillin 11
lysine 11
ROS 11
ascorbate 10
Vitamin E 10
Cardiovasc 10
Troglitazone 9
Monit 9
Estrogens 9
Amoxicillin 8
Leaf 8
caffeine 8
MAP 8
Ethanol 7
Secretin 7
Glutathione 7
Neoral 6
AMC 6
Albumin 6
Tacrolimus 5
IL-2 5
Augmentin 5
DMAP 5
Dial 5
Gel 5
Prednisolone 5
Augmentin 5
ALA 4
ENT 4
Dakar 4
Adriamycin 4
Bezafibrate 4
Cremophor EL 4
Fraction 4
Adenosine triphosphate 4
Photofrin 3
Nimesulide 3
Prednisone 3
niacin 3
Kenyan 3
Soybean oil 3
Alanine 3
Etoposide 3
ICI 3
Emodin 3
Vitamin B12 3
Emodin 3
Indomethacin 3
Meconium 3
Swertia 2
PCB 2
IFN-gamma 2
CTX 2
Meropenem 2
Bifidobacterium 2
Fructose 2
CCL 2
Zileuton 2
Cilostazol 2
Mesalazine 2
Heme 2
Histamine 2
Nephron 2
nitroglycerin 2
Mutagen 2
Bosentan 2
Iodipamide 2
Phenytoin 2
Ranitidine 2
Bupivacaine 2
Piperacillin 2
Diurnal 2
Clonidine 2
Rhubarb 2
Nephron 2
Meropenem 2
Serum albumin 2
Infliximab 2
Growth hormone 2
Bosentan 2
Phosphatidylserine 2
PTH 2
citric acid 2
Propofol 2
AZT 2
Vitamin A 2
TAC 2
Liposyn 2
Growth hormone 2
Indocyanine green 2
Monensin 2
Methylprednisolone 2
Galactose 2
Rituximab 2
AZT 2
Ketoconazole 2
AmBisome 2
uPA 2
ETA 2
Infliximab 2
DNase I 2
MgSO4 1
Trimethoprim-sulfamethoxazole 1
Cetrorelix 1
NAH 1
Phenprocoumon 1
THA 1
Retinoic acid 1
Colestimide 1
Cimetidine 1
Azithromycin 1
Lactose 1
Velban 1
Lenalidomide 1
Gold sodium thiomalate 1
Mirtazapine 1
Sorafenib 1
Biopolymers 1
CaCl2 1
CTA 1
Tannic acid 1
CaCl2 1
Propafenone HCl 1
Sesamol 1
Bayer 1
Spectrum 1
Micafungin 1
Mycophenolic acid 1
Eldepryl 1
Isoniazid 1
Fotemustine 1
Mercaptopurine 1
metformin hydrochloride 1
Orlistat 1
Miglustat 1
Temocillin 1
Taxol 1
DBS 1
Zinc acetate 1
Spectrum 1
ROC 1
Dazoxiben 1
Ganciclovir 1
Malonaldehyde 1
CTT 1
Nafcillin 1
DDAVP 1
Norplant 1
Nitisinone 1
Rutin 1
Cupric sulfate 1
more...
Enzyme
alkaline phosphatase 658
alanine aminotransferase 426
gamma-glutamyl transpeptidase 349
aspartate aminotransferase 302
AST 89
ATPase 77
lactate dehydrogenase 65
catalase 52
peroxidase 50
superoxide dismutase 44
mitogen-activated protein kinase 43
CYP7A1 38
P-glycoprotein 37
5'-nucleotidase 30
glutathione peroxidase 27
UDP-glucuronosyltransferase 25
protein kinase C 24
transpeptidase 24
caspase-3 22
cholinesterase 22
Mg2+-ATPase 22
luciferase 22
protein kinase 21
lipase 20
CYP3A4 19
ERK 18
ceruloplasmin 18
glutathione S-transferase 17
acetylcholinesterase 16
leucine aminopeptidase 15
cholesterol acyltransferase 14
lecithin:cholesterol acyltransferase 14
reverse transcriptase 14
beta-glucuronidase 13
AMP-activated protein kinase 13
pyruvate dehydrogenase 13
acid phosphatase 12
trypsin 12
CYP27A1 12
sorbitol dehydrogenase 11
NO synthase 11
hexosaminidase 11
demethylase 11
CPR 10
proteasome 10
glutathione reductase 10
NOS 10
ferrochelatase 10
renin 10
nucleotidase 10
glutamate dehydrogenase 9
glucose-6-phosphate dehydrogenase 9
MEK 9
arginase 9
glutamate dehydrogenase 9
CYP8B1 9
glutamate dehydrogenase 9
caspase-8 9
xanthine oxidase 8
collagenase 8
argininosuccinate synthetase 8
heme oxygenase 8
gamma-glutamylcysteine synthetase 8
calcineurin 8
focal adhesion kinase 7
AMPK 7
glutamine synthetase 7
diaphorase 7
NADPH oxidase 7
thromboplastin 7
urokinase-type plasminogen activator 7
NQO1 7
phosphodiesterase 7
elastase 6
thrombin 6
AMPK 6
alanine aminopeptidase 6
NADPH oxidase 6
aldehyde dehydrogenase 6
glucose-6-phosphatase 6
creatine kinase 6
succinate dehydrogenase 6
CD10 5
RNA polymerase 5
NADPH-diaphorase 5
CD13 5
pyruvate kinase 5
aldehyde dehydrogenase 5
MIP 5
neuraminidase 5
ACE 5
ALA synthase 5
HSD 5
aldehyde dehydrogenase 4
transcriptase 4
aldehyde dehydrogenase 4
histidase 4
lipoprotein lipase 4
type III procollagen 4
phosphoinositide 3-kinase 4
tissue plasminogen activator 4
APC 4
beta-lactamase 4
adenylate cyclase 4
alcohol dehydrogenase 4
aldehyde dehydrogenase 4
phosphorylase 4
sulfatase 4
BMT 4
PARP 3
cathepsin B 3
phosphoenolpyruvate carboxykinase 3
IMP dehydrogenase 3
MMP-3 3
3-hydroxyacyl-CoA dehydrogenase 3
neutrophil elastase 3
diaphorase 3
isocitrate dehydrogenase 3
myosin light chain kinase 3
isocitrate dehydrogenase 3
ribonuclease 3
RNase 3
3-hydroxy-3-methylglutaryl-CoA reductase 3
complex I 3
pyruvate dehydrogenase 3
ribonuclease 3
dipeptidyl peptidase IV 3
RNase 3
prolyl hydroxylase 3
beta-galactosidase 3
ornithine transcarbamylase 3
MAP 3
phosphoenolpyruvate carboxykinase 3
pyruvate dehydrogenase 3
dimethylarginine dimethylaminohydrolase 3
phosphoenolpyruvate carboxykinase 3
ATP synthase 3
caspase-9 3
CYP7B1 3
CPT 3
3-hydroxy-3-methylglutaryl coenzyme A reductase 2
phospholipase A1 2
citrate synthase 2
MMP 2
MDR 2
IKK 2
ornithine decarboxylase 2
alpha-amylase 2
cholesterol esterase 2
caspase-1 2
transglutaminase 2
diamine oxidase 2
asparaginase 2
LPL 2
lipoxygenase 2
mevalonate kinase 2
glycerol 3-phosphate dehydrogenase 2
thymidine kinase 2
chymotrypsin 2
tryptase 2
more...
Compound
Clin 987
Dec 565
salt 312
sodium 239
DNA 182
Ursodeoxycholic acid 153
glucose 147
calcium 139
water 128
copper 125
ATP 110
oxygen 90
GSH 81
GSH 81
iron 77
sulfate 72
methionine 70
nitric oxide 67
Estrogen 63
creatinine 59
urea 58
ethanol 58
arginine 57
Parenteral 55
acetate 55
His 53
vitamin D 53
alanine 52
phosphate 49
ALP 48
TNF 45
galactose 42
ANI 42
nitrogen 37
manganese 37
cAMP 36
adenosylmethionine 35
CCl4 34
ammonia 33
Cyclosporine 33
NADP 30
zinc 29
Cholesterol 28
Bilirubin 27
potassium 26
tyrosine 25
cysteine 25
glutamate 23
GPT 23
Lithocholic acid 23
GSSG 22
FK506 21
Rifampicin 21
Taurocholate 21
Chenodeoxycholic acid 20
APAP 19
NADH 19
IDA 18
Tauroursodeoxycholic acid 18
glutamine 18
phosphorus 17
Chlorpromazine 17
MDA 17
serine 17
Cholic acid 17
NADPH 16
iodine 16
Estradiol 16
NADPH 16
Sodium 15
aluminum 15
Melatonin 15
Luminal 15
retinol 14
ammonium 14
carbonate 14
ADP 14
Taurine 14
UDP 14
ADP 13
leucine 13
ADP 13
PAS 13
hydrogen 13
nitrate 13
N-acetylcysteine 13
lysine 13
Phe 12
Vitamin E 12
AMP 12
PEG 12
Gly 12
glycerol 12
threonine 12
Vitamin K 12
Insulin 11
Colchicine 11
Azathioprine 11
benzene 10
Malondialdehyde 10
LTC4 10
methanol 10
Mg2+ 10
NAD 10
CO2 10
aniline 10
Estrogen 10
A 3 10
uridine 9
Cardiol 9
DCA 9
bromobenzene 9
HCO 9
Silymarin 9
Curcumin 9
hydroxide 9
DCA 9
Amoxicillin 9
DOCA 9
Ile 9
homocysteine 8
caffeine 8
ornithine 8
prostacyclin 8
ornithine 8
hyaluronic acid 8
CoA 8
cholestane 8
cholan-24-oic acid 8
retinoic acid 8
isoleucine 8
Vitamin D 8
ornithine 8
NAD 8
proline 8
ornithine 8
Asp 8
A 42 8
cholestane 8
ornithine 8
isoleucine 8
cholan-24-oic acid 8
cholestane 8
palmitic acid 7
Griseofulvin 7
Rose Bengal 7
Naltrexone 7
INH 7
propylene glycol 7
nicotinamide 7
Phosphatidylcholine 7
selenium 7
GlcNAc 7
Glycochenodeoxycholic acid 7
Secretin 7
CAT 7
CAT 7
Collagen 7
SDS 7
CAT 7
more...