Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0008370 (
cholestasis
)
9,378
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted
1-naphthoic acid
1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the severity of
cholestasis
in the ANIT acute cholestatic rat model.
...
PMID:Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. 1862 23
