Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0008370 (cholestasis)
 9,378 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

116 patients with clinically suspected obstructive jaundice were subjected to primary sonographic examination by means of the "real-time" method to differentiate between intrahepatic (internal) and extrahepatic (surgical) cholestasis. Diagnosis was finally confirmed by observing the clinical course, by further examinations, and in 63 cases by surgery or PM. Sonographic examination revealed the direct cause of the extrahepatic obstruction in 82 of 87 patients (94.3%) with extrahepatic cholestasis; in case of dilatation of the bile duct, the approximate site of the obstruction could be determined. In about 75% of the cases, the cause of biliary obstruction was correctly identified. Intrahepatic tumours or metastases were present in 10 of 27 patients with intrahepatic cholestasis; sonographic identification was effected in all cases and histologically or cytologically confirmed with aspiration material from fine-needle biopsies. The high accuracy and uncomplicated technique avoiding discomfort or harm to the patient, make sonography a useful method in differential diagnosis of cholestasis.
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PMID:[Ultrasound in differential diagnosis of intrahepatic and extrahepatic cholestasis (author's transl)]. 69 86

The authors have studied the frequency of an abnormal lipoprotein (LP-X), by the method presented by YAE e col. (21). The LP-X test is useful in differentiating of a cholestatic process from a non-cholestatic one, but it is not adequate to distinguish an intrahepatic cholestasis from an extrahepatic biliary obstruction. Out of the 41 icteric patients who were studied, a frequency of the presence of the LP-X was observed in 68.3% thus distributed: viral hepatitis 90,5% obstructive jaundice 85,7%, jaundice of uncertain etiology 37.6%; it was not present in 5 patients with hepatic cirrhosis and in the serum of 21 healthy volunteers. A significant association was found between the presence of LP-X and an abnormal curve of lipoproteins.
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PMID:[Frequency of lipoprotein-X (LP-X) in icteric patients. Comparison with some bioquimical data (author's transl)]. 74 47

Percutaneous transhepatic cholangiography using a fine gauge (Chiba) needle was performed 41 times in 40 patients with jaundice or abnormal liver function. Their ages ranged from 3 months to 80 years and the youngest successful cannulation was carried out on a 15 month-old-child. There were 32 cases of ex-rahepatic biliary obstruction, the site being shown in 28 (87.5%) and the nature correctly predicted in 22 (69%). One of two cases in the post obstructive phase and one of two with intrahepatic cholestasis were cannulated and showed bile ducts of normal calibre. Three out of four cases with hepatocellular disease were successfully examined and obstruction excluded by showing normal bile ducts. Delayed films taken up to 2 h later were found valuable, particularly in cases of obstructive jaundice. The technique is easier and less expensive to perform than endoscopic retrograde cholangiography. No major complications occurred suggesting the modified technique is now a safe procedure for investigating jaundice or disordered liver function in both adults and children.
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PMID:Initial experience of percutaneous transhepatic cholangiography using a fine gauge needle. 87 13

Percutaneous cholangiography with the Okuda needle was performed in 42 consecutive patients with a clinical diagnosis of obstructive jaundice. Six had intrahepatic cholestasis. The technique demonstrated the biliary anatomy in 41 patients and the radiological diagnosis was confirmed by laparotomy, necropsy, or liver biopsy. There were no significant complications. Laparotomy, when indicated, was performed earlier in the course of the jaundice and it was avoided in seven patients. Precise knowledge of the site of the obstruction was of great help to the surgeon. We believe that this technique represents an important advance in the management of the jaundiced patient.
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PMID:Percutaneous cholangiography with the Okuda needle. 89 5

An abnormal lipoprotein can be detected in the sera of patients suffering from intra- and extrahepatic cholestasis. The specificity of LP-X detection for the diagnosis of cholestasis in adult persons was proved by extensive investigations. The aim of this study was to examine the specificity of LP-X with regard to cholestasis in the postnatal phase of premature and newborn infants. 1056 sera of 270 newborns were tested and in 75% of these cases LP-X was found to be positive. Three hypothetical explanations are given concerning the appearance of LP-X in the sera of premature and newborn infants. The semi-quantitative determination of LP-X also represents a possibility for differential diagnosis of obstructive jaundice in the neonatal period.
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PMID:[LP-X in the first month of life (author's transl)]. 90 43

The apparent well-being of some children who as neonates were believed to have obstructive jaundice prompted us to study the clinical course, histologic features and possible etiologic factors in 17 children with cholestasis in the neonatal period. During a follow-up period of five months to 22 years, all had signs of chronic cholestasis, but only four died (two from nonhepatic causes); the others live remarkably normal lives. Serial hepatic biopsies in 11 showed a variety of initial lesions, which progressed to hypoplasia of the intrahepatic bile ducts, increasing portal fibrosis and eventual cirrhosis. Although evidence of possible viral infection was found in only 10 cases, a hepatitis, beginning either before or after birth, appears to be a likely original cause. The histologic changes seen may represent different stages of one process, starting as cholestasis with or without evidence of hepatitis and progressing to obliteration or failure of normal growth of the intrahepatic bile ducts.
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PMID:Intrahepatic cholestasis in childhood. 95 76

In 7 infants suffering from obstructive jaundice we found transient high levels of methionine in serum. All cases had only intrahepatic cholestasis, especially with intrahepatic biliary hypoplasia, whereas other patients with extrahepatic biliary atresia and/or combination of extra- and intrahepatic obstructive jaundice always showed normal levels of methionine. Therefore hypermethioninemia seems to be helpful in differentiating the various causes of infantile obstructive jaundice.
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PMID:[Hypermethioninemia in the differential diagnosis of infantile obstructive jaundice (author's transl)]. 99 34

Rats were subjected to ligation of the common bile duct to provoke bile ductular proliferation and were studied at intervals from 1 day to 6 weeks. After perfusion fixation with glutaraldehyde, and ethanol dehydration, blocks of liver were frozen in liquid nitrogen, fractured, and returned to ethanol prior to critical point drying. Examination with the scanning electron microscope showed a remarkable proliferation of bile ductules and preductules in addition to canalicular dilation. The ductules were surrounded by a longitudinal array of collagen fibers. The luminal surfaces contained many microvilli and cable-like structures, some identifiable as cilia by transmission electron microscopy. The present techniques offer the possibility for a reevaluation of obstructive jaundice and cholestasis.
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PMID:Scanning electron microscopy of proliferating bile ductules. 116 Mar 51

The simultaneous measurement of wedged hepatic venous pressure and portal venous pressure at 11 and 28 days following common bile duct and intrahepatic bile duct obstruction reveals a significant elevation of the portal pressure at 28 days which is due primarily to increased presinusoidal resistance to portal blood flow. Portal venograms performed prior to sacrifice revealed moderate narrowing of the portal vein radicles and delayed emptying at 11 days and severe morphological alterations at 28 days. These results confirm the findings of other investigators and help to explain why the hemodynamic alterations occur so rapidly in obstructive jaundice, well before the development of significant biliary cirrhosis.
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PMID:The location of increased resistance to portal blood flow in obstructive jaundice. 125 22

In 299 patients with negative cholecystocholangiogram, endoscopic retrograde cholangio-pancreatography (ERCP) was performed. In obstructive jaundice ERCP is the method of choice, while in cholestasis it is indicated if the intravenous cholecystocholangiogram is insufficient. In unclear abdominal conditions and in "postcholecystectomy syndrome" ERCP may be carried out after other abdominal diseases have been ruled out.
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PMID:[The value of endoscopic retrograde cholangiopancreatography in negative or undetermined cholecystocholangiography]. 125 30


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