Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0008325 (
cholecystitis
)
3,686
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We describe a 40-year-old woman with
Salmonella
cholecystitis
complicating adult-onset X-linked chronic granulomatous disease (CGD) caused by a
de novo
mutation in the paternal-origin
CYBB
gene. CGD was diagnosed by familial genetic analysis of the
CYBB
gene encoding NADPH oxidase gp91
phox
after detection of a refractory subcutaneous abscess at the age of 28. At age 40, she began experiencing frequent fever and diarrhea over a period of 3 months that were refractory to antibacterial treatment.
Cholecystitis
was evident. Her symptoms improved after percutaneous trans-hepatic gallbladder aspiration puncture with stand-by cholecystectomy.
Salmonella enterica
serotype Enteritidis (
S.
Enteritidis) was detected in blood, stool, and bile acid samples. Due to her suppressed bactericidal ability caused by CGD,
S.
Enteritidis was considered to have translocated from the gut to reside in the gallbladder, causing her repeated enteritis and sepsis. When encountering CGD with recurrent salmonellosis, the possibility of
cholecystitis
should be considered as another infection focus.
...
PMID:
Salmonella
Enteritidis cholecystitis with chronic granulomatous disease. 2994 48
