Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0008031 (chest pain)
 17,248 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Granular cell myoblastoma of the bronchus is rare. Two patients are described, bringing the total reported to 44. Review of the literature shows that cough, chest pain, hemoptysis, and wheezing are frequent presenting symptoms and that distal atelectasis and recurrent or persistent pneumonitis are common roentgenographic findings. Though the histogenesis of this tumor remains controversial, most pathologists now believe that the cells have a neurogenic origin. Adequate open surgical resection is the treatment of choice.
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PMID:Granular cell myoblastoma of the bronchus: report of 2 cases and review of the literature. 18 48

In this retrospective study of 115 cases of histoplasmids, there were 66 male and 49 female patients ranging in age from 2 months to 79 years. The most common presenting symptoms were cough, chest pain, wheezing, weight loss, hemoptysis, and shortness of breath. Thirty-five patients (30%) were asymptomatic. Two patients had manifestations of obstruction of the superior vena cava. Radiologic findings simulated carcinoma, tuberculosis, pneumonia, and viral infections. Sixty-five patients had various operative proceudres, such as lung biopsy, wedge resection, lobectomy, pneumonectomy, resection of lymph node, and bypass of superior vena cava, for diagnosis and treatment. There were two deaths and two postoperative complications. A total of 15 patients received intravenous amphotericin B. Four patients with pneumonic infiltrates developed disseminated histoplasmosis.
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PMID:Histoplasmosis: clinical manifestations and surgical management. 47 35

Classical symptoms and signs common to most pulmonary diseases, such as dyspnea, cough, chest pain and cyanosis, are reviewed to assess their significance for diagnosis and evaluation of the degree of impairment in acute respiratory failure. While frequently useful for diagnosis, they are often inadequate to determine the degree of emergency. In each particular etiology other information is needed to obtain an objective and quantitative assessment. Two examples selected for their frequency are considered: barbiturate intoxication and severe exacerbations of asthma. The severity of barbiturate poisoning can be assessed clinically in the light of the degree of central nervous depression. Classical signs and wheezing are poorly correlated with the intensity of acute asthmatic attacks, but high-risk patients can be identified by seeking neglected physical findings such as pulsus paradoxus and sternomastoid muscle contraction. In many other pulmonary emergencies further studies are required to assess the usefulness of various clinical signs as objective indices of the severity of respiratory impairment.
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PMID:[Various aspects of respiratory emergencies in non-hospital practice]. 53 46

Five asthmatic patients developed collapse of one lung. Three of the patients were children and three of the five had repeated episodes of atelectasis. Episodes of atelectasis were usually associated with localised chest pain, which was not pleuritic in character, and with breathlessness, but without wheezing. The were not related to clinically apparent respiratory infections or to deterioration of the underlying asthma. The cause is obscure, but re-expansion seems to be hastened by oral corticosteroid therapy.
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PMID:Unilateral pulmonary collapse in asthmatics. 66 80

28 cases of allergic bronchopulmonary mycosis (ABPM) were diagnosed by criteria formulated in 1977 by Rosenberg and by referring to the results of serum IgE-Af and IgG-Af detection. The common clinical features were wheezing, fever, bloody sputum, sputum plugs, chest pain and loss of energy. On chest X-ray, infiltrates were found in 28 cases, fibrosis in 12, atelectasis in 4, lobar shrinkage in 1, and aspergilloma in 1, Chest films in 14 cases showed shadows suggesting in the presence of CB. Tomography (linear and/or axial) showed CB in 9 cases. All the cases had positive immediate reactions in skin test to moulds. Serum precipitating antibody against moulds were demonstrated in 27 cases. A cross reactivity exists among moulds either in skin test or in gel double diffusion technique. The sensitizing mould was chiefly Aspergillus species, especially Af. Serum IgE-Af and IgG-Af were measured in 14 cases caused by Af. The mean OD value was over 2 times greater than that in the patients with asthma who had positive skin test to Af. Corticosteroids were used for treatment, and the results of followup of 23 cases suggested that such long term complications as CB, fibrosis and refractory bacterial infection were the chief causes of poor prognosis.
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PMID:[Clinical and immunological features of allergic bronchopulmonary aspergillosis]. 166 Jul 74

The frequency and the possible age-related characteristics of gastro-oesophageal reflux disease (GORD) were investigated in 195 consecutive elderly subjects (mean age 74 years), referred to endoscopy for abdominal symptoms or sideropenic anaemia. In the 105 of these patients in whom there was any suspicion of GORD, 24-hour pH monitoring was carried out. All the patients were interviewed before the examinations. Erosive or complicated (grade 2-4) oesophagitis was found in 18% of patients. The main symptoms in these patients were dysphagia, respiratory symptoms and vomiting. Chronic cough, hoarseness or wheezing were present in 57% of patients with oesophagitis compared with 33% of those without oesophagitis (p less than 0.001). The occurrence of heartburn and regurgitation did not differ significantly between patients with or without oesophagitis, although the mean symptom scores were higher in those with oesophagitis. Dyspepsia and chest pain were not typical symptoms in oesophagitis. Of patients with oesophagitis 29% had no typical symptoms of GORD; only 24% of patients with regurgitation had oesophagitis. In 24-hour pH monitoring, a significant increase in the occurrence of symptoms was not seen until total reflux time pH less than 4 exceeded 10%. The occurrence of heartburn did not correlate with the extent of reflux in the pH study. In conclusion, typical symptoms of GORD in the aged were regurgitation, dysphagia, respiratory symptoms and vomiting rather than heartburn.
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PMID:Symptoms of gastro-oesophageal reflux disease in elderly people. 175 93

A 66-year-old woman, who had had bronchial asthma, was admitted to our hospital because she suffered from fever, productive cough, wheezing, dyspnea, and chest pressure sensation. Her chest X-ray showed migrating infiltration and marked cardiomegaly. Her ECG at the admission revealed abnormal Q wave and T wave inversion, though that of 3 years before had been almost normal. Hematology showed leukocytosis and eosinophilia of 8,000/mm3 without abnormal cells. All immunological tests were negative and the specific cause of the eosinophilia was unknown. 2 weeks after admission, she complained of severe chest pain suddenly and her ECG showed ST elevation on V1-4 and serum CPK level was elevated to 290 IU/l. By the thrombolytic agent and anticoagulant therapy, her symptom was lightened immediately. 2 months later, we made her cardiac catheterization and myocardial biopsy. Her LVG showed a small aneurysm of the apex, though her CAG was normal finding. The biopsy revealed moderate fibrosis and cellular infiltration including a few eosinophils. We thought that eosinophilic endocarditis had existed first, and secondary embolism continued led to the small infarction. The hypereosinophilia was spontaneously normalized 2 months after admission, but the patient complained of myalgia and sensory disturbance of extremities. The biopsy of quadriceps muscle could prove neither infiltration of eosinophils nor vasculitis. But we diagnosed mononeuritis multiplex due to hypereosinophilia. Judging from various symptoms and laboratory findings, this case was included to the hypereosinophilic syndrome. We also thought allergic granulomatosis and angitis as one of the differential diagnoses, but histologically vasculitis was not proved. In this case, eosinophilia was disappeared without using corticosteroids.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A case of hypereosinophilic syndrome associated with eosinophilic endocarditis]. 261 22

One hundred forty-five male welders from a West Coast shipyard were studied cross-sectionally and across a Monday work shift by pulmonary function tests and a questionnaire. Ten years of welding was associated with chronic bronchitis in 23.3% of nonsmokers compared to 3.3% in male controls, shortness of breath in 31.5% of nonsmokers compared to 1.5% in controls, and chest pain or heaviness in 38.4% compared to 4.4% in controls. Men who welded aluminum but had never smoked had more frequent wheezing, chest tightness, phlegm, feverishness and fatigue than those welding mild (black) or stainless steel. There were no significant cross-shift effects from welding exposure on measurements of pulmonary function. Although baseline expiratory flows were reduced slightly when compared to Caucasian-predicted values, ethnic specific comparisons for the largest subgroup showed only that FEF25-75 was reduced to 92.9 percentage of predicted values. Diffusing capacities for carbon monoxide were significantly reduced as compared to referents. The pulmonary function values of 25 current smokers were indistinguishable from the 41 who had never smoked, which probably reflects their low consumption of cigarettes.
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PMID:Respiratory symptoms and functional impairment from acute (cross-shift) exposure to welding gases and fumes. 281 87

Asthma is an important cause of morbidity in children, and prompt diagnosis and treatment are essential. Asthma has a wide variety of clinical manifestations. Chest pain variant asthma is an important subset of cough variant asthma. A high index of suspicion is required to make the diagnosis. Wheezing is not always present in asthma. Another manifestation, such as chronic cough or chest pain, may be the sole presenting complaint.
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PMID:Variant forms of asthma. 350 8

We performed antireflux surgery on 13 adults with both gastroesophageal reflux (GER) and asthma. The duration of asthma ranged from 7 months to 43 yr. Twelve patients had chronic heartburn, 10 had nocturnal cough and wheezing, eight had chest pain, and one was asymptomatic for GER. GER was determined by a combination of esophagoscopy with biopsy, manometry, and esophageal pH testing. Postoperative follow-up ranged from 13 months to 5 yr. Six patients were completely free of all wheezing episodes, six still had wheezing but the frequency and severity had markedly decreased, and one remained unchanged. Of 11 patients who required chronic bronchodilator therapy, four were able to completely stop and six decreased the dose by more than half; one required the same amount of therapy. Of the seven corticosteroid-dependent patients, two were weaned completely, three were being tapered, one remained unchanged, and one required a smaller dose for nasal polyps although he was free of wheezing and had stopped bronchodilators. Three patients, all of whom dramatically improved after surgery, died during their follow-up course: one died suddenly 8 months postoperatively during a walk after dinner from apparent status asthmaticus; one died 9 months postoperatively of refractory congestive heart failure; and one died 30 months postoperatively of metastatic adenocarcinoma of unknown source. We conclude that surgical correction of GER in selected adults with both asthma and GER may significantly decrease or eliminate pulmonary symptoms and the need for asthmatic medications.
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PMID:Is gastroesophageal reflux a factor in some asthmatics? 381 16


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