Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0008031 (chest pain)
 17,248 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 19-year-old male patient with type 1 Gaucher disease was put on regular biweekly infusions of alglucerase. After 1 yr of treatment, hepatic and splenic volumes decreased from 38 and 45 mL/kg to 31 and 34 mL/kg, respectively. In addition, hemoglobin concentration, platelet count and white cell count increased, acid phosphatase level decreased, and the patient gained weight and energy. Despite improvement, the patient refused enzyme replacement therapy (ERT) because of muscle rigidity, chest pain, trembling and anxiety, which he attributed to enzyme substitution. Two and 4.5 year after cessation of therapy, hepatic and splenic volumes increased to 36 and 53 mL/kg and to 53 and 110 mL/kg, respectively. The patient developed non-tractable hematuria because of compression and dislocation of the left kidney by the enlarged spleen, which necessitated splenectomy. This report suggests that cessation of ERT in Gaucher disease may result in severe and complicated rebound visceromegaly.
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PMID:Rebound hepatosplenomegaly in type 1 Gaucher disease. 1258 Nov 95

Bones localization of hydatic disease is extremely rare (0.5-2.5 %). In approximative 50% of the cases of bones hydatidosis, the cysts are localized at spines vertebrae, broad bones and mandible. We present a case of a 38 years old female. The patient related an insidious beginning of symptoms, about 3-4 years before, with anterior chest pain, and 3-4 month before hospitalization, the presence of a sternal tumor, in upper portion of the bone. Clinical examination of the patient showed a sternal tumor, at manubrium, painful at palpation, increased consistency, with local inflammation signs. Also, the patient related pain at sterno-clavicular articulation, increased by left upper limb motions, but without mobility restriction. Biochemical analysis revealed an moderate inflammatory syndrome: blood cell sedimentation speed = 40 mm/h, WBC = 9600/mmc, E = 3%, Hb = 11.8g/100ml, alcaline and acid phosphatase - normal range. Thoracic scan: sternal tumor at manubrium with invasion at sternoclavicular joint and bone destruction. Intraoperative we discovered that the sternal tumor was in fact an hydatic cysts, confirmed by the anatomo-pathological exam; we performed cysts removal and resection of osteitic bone. Postoperative outcome was favorable, with antiparasitic treatment after surgery; no recurrence of the hydatic disease or secondary localization.
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PMID:[Particular localisation of hydatic disease--sternum]. 1927 19