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Query: UMLS:C0008031 (chest pain)
 17,248 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirteen patients with ischemic coronary heart disease purposely hyperventilated for seven minutes in order to induce hypocapnic alkalosis. One patient experienced chest pain, and one exhibited chemical signs of myocardial hypoxia. Heart rate, blood pressure and myocardial O2 consumption did not change significantly. Coronary blood flow decreased and coronary (a-v)O2 difference widened. Since the alkalosis increased the blood O2 affinity, the fall in PO2 in coronary venous blood was proportionately even greater than the fall in O2 concentration. Thus, hypocapnic alkalosis due to hyperventilation interferes with myocardial O2 supply by 1) coronary vasoconstriction and 2) increased O2 affinity of blood.
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PMID:Impairment of myocardial O2 supply due to hyperventilation. 117 66

Patients with prolapsing mitral leaflet syndrome (PML) frequently have chest pain of undetermined etiology. Twenty-three patients with PML underwent cardiac hemodynamic, angiographic, and metabolic studies. The latter were performed during control spontaneous heart rate and tachycardia by right atrial pacing. Myocardial supply-demand ratio (DPTI:SPTI) was estimated from the planimetric integration of the diastolic area (diastolic pressure time index = DPTI) and systolic area (systolic pressure time index = SPTI) of the central aortic pressure. Chest pain during pacing occurred in five patients. In two patients, it was associated with ST depression typical of ischemia on the electrocardiogram. Myocardial lactate abnormalities (lactate production or less than 10% extraction) occurred in seven patients during pacing tachycardia and was present in two patients during control state. DPTI:SPTI ratio during control state was 1.22 (+/- 0.07 SE) and decreased to 0.85 (+/- 0.05 SE) during pacing tachycardia. It is concluded that the myocardial lactate abnormalities in PML, which were present in approximately 30% of the patients in the present series, are most likely due to myocardial hypoxia. Whether or not the hypoxia is secondary to "small vessel disease" is not elucidated by this study.
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PMID:Myocardial metabolic studies in prolapsing mitral leaflet syndrome. 118 56

Coronary angiography performed in a 62 year old man with spontaneous chest pain revealed a congenital fistula in the form of a vascular network arising from the proximal part of the left anterior descending artery and draining into the main pulmonary artery. A single severe atheromatous stenosis of the right coronary artery was observed. Thallium 201 myocardial scintigraphy at rest showed a large area of hypofixation in the artero-septo-apical zone. Myocardial and aorto-right coronary bypass, myocardial scintigraphy became almost normal, leaving a small antero-septal and apical deficit: myocardial metabolism returned to normal. The fact that lactate metabolism is a particularly sensitive index of myocardial hypoxia in the territory of the left coronary artery suggests a probable coronary steal syndrome induced by the fistula; this is probably also the cause of the isotopic hypofixation in the territory of the left anterior descending artery which emphasizes the value of Thallium myocardial scintigraphy in the study of congenital malformations of the coronary artery.
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PMID:[Coronary arteriovenous fistula. Apropos of a case with thallium myocardial scintigraphy and study of pre- and postoperative myocardial metabolism]. 681 Jul 93

It is almost twenty-five years since stress myocardial perfusion imaging was first described for the detection of ischemia. Since that time, significant refinements have occurred in the technology of making the measurements, and in the range of clinical indications to perform these measurements. In parallel with the growth of radionuclide techniques, other imaging technologies have developed substantial tools to examine the heart. Although radionuclide imaging remains unique in its ability to visualize the regional distribution of perfusion, the value of perfusion imaging is being called into question by practitioners of the competing technologies. To address these comments, every facet of the examination should be reviewed, and the examination tailored to answer the specific clinical question raised by the patients condition. Particular attention should be paid to data interpretation and the specific choice of words used to describe the images in the report. In addition, the information provided by the examination can be enriched by adding measurements of ejection fraction, regional wall motion and regional wall thickening to the procedure. This combination of additional data and a clear, clinically focussed report make the information more valuable to the referring clinician. Several new techniques are on the horizon, including 99mTc glucarate imaging, to identify acute myocardial necrosis, and direct identification of myocardial hypoxia with 99mTc labeled nitroimidazoles. Initial studies in humans with glucarate suggest that acute necrosis can be identified with one hour of onset of chest pain. Experimental studies with the nitroimidazoles suggest that they will be valuable to identify myocardial ischemia as a zone of increased uptake. Both techniques may be useful in the evaluation of patients presenting with chest pain syndromes in the emergency room. Other areas of potential promise include the possibility of detecting residual clots following thrombolytic therapy and identifying macrophages in unstable plaque.
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PMID:Myocardial perfusion imaging: perspectives from a turbulent twenty-five years. 868 Oct 9

We describe the case of a patient who was admitted to the internal ward because of carbon monoxide poisoning. The examined level of carboxyhemoglobin measured 32%. The patient did not complain of any chest pain, but the features of myocardial hypoxia were observed in the electrocardiogram and significantly increased level of troponin T was revealed in laboratory tests. The ischaemic abnormalities ceased after normalization of carboxyhemoglobin level and the stress test was negative. Within the submitted study we report the possible interaction between carbon monoxide and cardiovascular system.
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PMID:[Acute myocardial ischemia after carbon monoxide exposure: a case report]. 1700 71