Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0007758 (cerebellar ataxia)
 3,609 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Posterior petrous meningiomas (commonly termed posterior pyramid meningiomas and/or meningiomas of the posterior surface of the petrous pyramid) are the most common meningiomas of the posterior cranial fossa. They are located along the posterior surface of the temporal bone in the region of the cerebellopontine angle. They often mimic vestibular schwannomas, both clinically and on neuroimaging studies. Common clinical symptoms include hearing loss, cerebellar ataxia, and trigeminal neuropathy. The site of dural origin determines the direction of cranial nerve displacement. Total resection can be achieved in most cases with a low morbidity rate and an excellent prognosis. The authors review the surgical management of posterior petrous meningiomas.
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PMID:Surgical management of posterior petrous meningiomas. 1566 92

CNS complications of LCH include "space occupying" lesions corresponding to histiocytic granulomas and "neurodegenerative" presentation (ND-LCH) characterized by a progressive cerebellar ataxia. Studies analyzing specifically the MRI presentation of ND-LCH are scarce. We present here the MRIs of 13 patients registered as isolated ND-LCH. Posterior fossa was involved in 12 patients (92%), showing a symmetrical T2 hyperintensity of the cerebellar white matter areas in seven cases with a circumscribed T1 hyperintensity of the dentate nuclei in five cases, definite hyperintense T2 areas in the adjacent pontine tegmentum white matter in nine cases associated with a hyperintensity of the pontine pyramidal tracts in four cases. A cerebellar atrophy was noted in eight cases. The supratentorial region was involved in 11 patients, showing T2 hyperintense lesions in the cerebral white matter in eight cases and a discrete symmetrical T1 hyperintense signal in the globus pallidus in eight patients. A diffuse cortical atrophy was present in three cases and a marked focal atrophy of the corpus callosum in three cases. This series allows us to establish a not previously reported evocative semeiologic MR presentation to precisely orientate to the diagnosis of the pure neurodegenerative form of LCH.
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PMID:MRI features of neurodegenerative Langerhans cell histiocytosis. 1662 52