Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0007570 (celiac disease)
 13,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

[3H]Dopamine ([3H]DA) is specifically taken up by slices of rabbit celiac artery. Corticosterone, a selective inhibitor of extraneuronal uptake processes, was found to reduce the uptake of the labelled catecholamine by about 30%. Desimipramine, an inhibitor of uptake processes in noradrenergic neurons, caused a decrease of [3H]DA uptake of about 35%. Benztropine, an inhibitor of uptake processes in dopaminergic neurons reduced [3H]DA uptake by about 30%. The neuronal uptake of [3H]DA was completely inhibited by chemical sympathectomy or by simultaneous incubation of the slices with desimipramine and benztropine. Norepinephrine had a competitive effect on [3H]DA uptake and benztropine inhibited [3H]norepinephrine uptake by 32%. The results are consistent with the existence of a double noradrenergic and dopaminergic innervation of the rabbit celiac artery.
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PMID:Detection of neuronal uptake of [3H]dopamine in the rabbit celiac artery. 640 41