Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0007570 (celiac disease)
 13,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a prospective study of 300 carotid endarterectomies, ocular pneumoplethysmography (OPG-Gee) was performed in the recovery room after all procedures. Positive test findings, indicative of occlusion of the repaired vessels, were encountered after 16 (5%) of these procedures, and all 16 patients were completely asymptomatic. Serial test results, without angiographic confirmation, have remained positive in nine. Angiography confirmed the positive test results in three. Immediate reoperation, without angiography, confirmed the positive test findings in four, and normal flow was restored in all four cases. Success of carotid endarterectomy should not be measured by absence of symptoms. Objective documentation of persistent patency is essential. Present policy dictates that if recovery room test results are positive, the patient be returned to the operating room as soon as possible, with no delay for angiography.
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PMID:Postendarterectomy carotid occlusion. 731 44

In 15 patients with unilateral internal carotid artery occlusion and contralateral internal carotid artery stenosis of pressure significance (75% cross-sectional area or greater), the ocular pneumoplethysmograph (OPG-Gee) has documented bilateral improvement in the ophthalmic systolic pressure in 12/15 patients who underwent endarterectomy of the stenosed carotid artery as the sole operative procedure. External carotid to internal carotid shunt on the side of the internal carotid occlusion need be entertained only in those patients who remain symptomatic on the side of the internal carotid occlusion after contralateral stenosis endarterectomy.
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PMID:Carotid stenosis plus occlusion: endarterectomy or bypass? 735 33

As the increase in lifespan brings to light diseases that were previously not clinically detectable, osteoporosis has become an issue of worldwide significance. The disease is marked by a loss of bone mass; the bones become less dense, fragile and more prone to fracturing. Because it is regulated by endocrine and environmental factors, osteoporosis presents a multifactorial etiopathogenesis, with the genetic component accounting for 70% of an individual variation in bone mass density (BMD), the principal determinant, with age, of fracture risk. Pathological conditions such as celiac disease (CD) exacerbate the process of bone loss, so that the occurrence of osteoporosis in celiac subjects is of particular note: indeed, the screening of osteoporosis patients for this disease is advisable, since it may be the only sign of undiagnosed CD. An increase in interleukin IL-1beta, of the IL-1 system, in the relatives of celiac patients confirms the genetic predisposition to osteoporosis and its presence is evidence of an association between the two conditions. The direct effect on the bones of CD is secondary to poor absorption of calcium and vitamin D. In women osteoporosis is indirectly associated with early menopause and amenorrhea, and it may follow prolonged breast-feeding and frequent pregnancies, while in men it is associated with hypogonadism and GH deficit. These endocrine and non-endocrine factors exert their effects on bones by modulating the RANK/RANK-L/OPG system. An appropriate lifestyle from adolescence onwards, together with early diagnosis of and treatment for CD and primary and secondary endocrine pathologies are important for the prevention of damage to the bones.
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PMID:Osteoporosis in celiac disease and in endocrine and reproductive disorders. 1820 79

Osteoporosis is characterized by a loss of bone mass; the bones become less dense, fragile and prone to fracturing. It is regulated by endocrine-environmental factors with the genetic component accounting for 70% of an individual's variation in bone mass density (BMD). Pathological conditions such as celiac disease (CD) exacerbate the process of bone loss and the presence of osteoporosis in celiac subjects may be the only sign of undiagnosed CD. The interleukins IL-1alpha and IL-1beta are stimulators of bone resorption; the relatives of celiac patients shown the increased IL-1beta supporting the genetic susceptibility. In women osteoporosis is indirectly associated with early menopause and amenorrhea, while in men it is associated with hypogonadism and GH deficit. The direct effect on the bones of CD is secondary to poor absorption of calcium and vitamin D. These endocrine and non-endocrine factors exert their effects on bones by modulating the RANK/RANK-L/OPG system.
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PMID:Risk of osteoporosis in endocrine disorders and celiac disease. 1820 77


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