Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0007222 (cardiovascular disease)
 65,817 document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 6174
Sep 4147
HDL 2443
C-reactive protein 1949
Mol 1810
renin 1199
fibrinogen 868
albumin 756
hemoglobin 741
cytokine 726
angiotensin II 654
gut 638
adiponectin 630
collagen 532
leptin 520
IL-6 499
tumor necrosis factor 462
TNF 450
apolipoprotein 427
CRP 424
interleukin-6 414
Lp(a) 393
nitric oxide synthase 393
apolipoprotein B 386
LDL receptor 359
Ang II 336
ACE 335
ATP 331
vascular endothelium 326
natriuretic peptide 323
Men 313
plasminogen activator inhibitor-1 311
angiotensin receptor 307
superoxide dismutase 305
calcium channel 298
endothelial nitric oxide synthase 285
reductase 278
chronic renal failure 272
glucagon 257
thrombin 251
HMG-CoA reductase 247
proprotein convertase subtilisin/kexin type 9 242
parathyroid hormone 237
apolipoprotein E 236
SBP 233
endoplasmic reticulum 223
apoE 214
CHD 209
ACS 208
endothelin-1 207
estrogen receptor 207
adipokine 207
peroxisome proliferator-activated receptor 205
B12 201
vascular cell adhesion molecule-1 196
von Willebrand factor 196
vascular endothelial growth factor 195
catalase 195
angiotensin II receptor 185
Adiponectin 182
A-I 181
DBP 179
serum albumin 178
MRI 178
lipopolysaccharide 176
plasminogen activator inhibitor 174
EPA 169
GLP-1 receptor 167
PLA 166
eNOS 164
glutathione peroxidase 163
glycoprotein 158
caspase-3 158
lipoprotein lipase 154
erythropoietin 152
mineralocorticoid receptor 152
SARS 148
ROS 148
growth hormone 147
apolipoprotein A-I 146
more...
Disease
cardiovascular disease 65817
diabetes 13560
hypertension 12024
obesity 8296
atherosclerosis 7790
cancer 5998
type 2 diabetes 5277
stroke 4945
metabolic syndrome 3997
myocardial infarction 3782
heart failure 3361
dyslipidemia 2888
coronary heart disease 2878
coronary artery disease 2813
renal disease 2253
myocardial ischemia 1698
heart disease 1629
plaque 1422
hypercholesterolemia 1416
depression 1406
hyperlipidemia 1398
vascular disease 1227
osteoporosis 1154
hyperglycemia 1130
ischemia 901
glucose intolerance 886
HIV 879
congestive heart failure 842
acute myocardial infarction 819
Alzheimer's disease 816
chronic disease 813
breast cancer 783
ventricular hypertrophy 762
renal failure 741
chronic renal failure 655
rheumatoid arthritis 648
dementia 625
abdominal obesity 572
chronic obstructive pulmonary disease 560
cardiomyopathy 537
tumor 526
fatty liver 514
obstructive sleep apnea 514
atherosclerotic cardiovascular disease 503
anemia 503
proteinuria 500
hyperhomocysteinemia 480
hyperinsulinemia 476
AIDS 470
cardiovascular risk factor 467
infectious diseases 458
microalbuminuria 457
essential hypertension 426
preeclampsia 422
asthma 416
polycystic ovary syndrome 415
type 1 diabetes 399
systemic lupus erythematosus 386
liver disease 383
malnutrition 372
erectile dysfunction 364
diabetic nephropathy 362
arthritis 362
peripheral vascular disease 358
cognitive impairment 341
sleep apnea 336
retinopathy 325
cirrhosis 317
psoriasis 310
Chronic kidney disease (CKD) 307
Endothelial dysfunction 305
Nonalcoholic fatty liver 298
lung cancer 297
vitamin D deficiency 296
respiratory disease 296
prostate cancer 281
arteriosclerosis 274
pulmonary hypertension 262
hypoglycemia 260
immunodeficiency 260
more...
Symptom
overweight 1590
angina 599
pain 383
fatigue 244
chest pain 219
anesthesia 179
dyspnea 161
menopausal symptoms 156
headache 125
sleepiness 117
insomnia 100
weakness 96
diarrhea 87
syncope 87
cough 82
seizures 81
collapse 77
snoring 72
discomfort 70
discomfort 67
exhaustion 64
nausea 63
respiratory distress 60
hot flushes 55
acute stress 53
hot flashes 52
cachexia 51
dizziness 49
flushing 46
myalgia 42
hunger 39
shortness of breath 37
starvation 37
constipation 37
vomiting 33
Depressive symptoms 33
stigma 31
spasm 30
thinning 29
functional recovery 29
hypercapnia 28
anorexia 27
regurgitation 26
abdominal pain 26
analgesia 26
back pain 26
arthralgia 23
night sweats 20
memory loss 17
CSR 17
hypothermia 16
hoarseness 15
Stiffness 14
Multimorbidity 14
tremor 13
exertional dyspnea 12
Ill 12
agitation 12
low back pain 12
nausea and vomiting 12
hepatomegaly 11
nasal congestion 11
vertigo 11
hemoptysis 10
tinnitus 10
irregular bleeding 10
cyanosis 10
numbness 10
wheezing 9
peri-menopausal 9
apathy 9
Ortner's syndrome 9
leg pain 9
hyperoxia 9
hemiplegia 8
Poor sleep 8
orthopnea 8
ENT 7
HSA 7
cardiovascular impairment 7
more...
Drug
Cardiovasc 2666
vitamin E 376
Dial 336
ascorbate 286
niacin 223
EPA 150
ROS 148
Dermatol 146
Angiotensin II 130
Monit 127
lysine 103
caffeine 95
Vitamin E 81
Simvastatin 77
nitroglycerin 77
MAP 71
Nephron 64
Nephron 52
ROC 52
Rosuvastatin 51
Estrogens 49
Ramipril 47
PTH 47
Ezetimibe 46
Pravastatin 46
Glucagon 46
EE2 45
Clopidogrel 45
Leaf 40
SiO2 39
ADM 37
IL-2 34
Spectrum 34
Nitric Oxide 33
Raloxifene 32
Albumin 32
THF 30
BH4 29
ICI 29
Valsartan 28
Lovastatin 28
Asthma 27
ALA 27
Perindopril 26
Rosiglitazone 26
Vitamin K 25
ABC 25
ETA 24
Olive oil 24
NADH 24
Growth hormone 23
Heme 23
Ethanol 23
Growth hormone 22
Fructose 22
Liraglutide 22
ZnO 22
Bifidobacterium 21
IFN-gamma 21
ENT 21
CSF 20
Vitamin A 17
Norplant 17
Viagra 17
Alliance 16
Award 16
Rimonabant 16
Gliclazide 15
EPI 15
Nebivolol 15
Glutathione 15
TiO2 14
pyridoxal phosphate 14
Ginseng 14
Wine 14
CTX 14
Check 14
Aliskiren 13
PFA 13
Tocopherol 12
more...
Enzyme
renin 1199
ACE 575
mitogen-activated protein kinase 404
superoxide dismutase 365
thrombin 242
NO synthase 229
protein kinase 227
NADPH oxidase 226
catalase 214
ACS 208
ERK 197
NADPH oxidase 183
tissue plasminogen activator 182
AMP-activated protein kinase 174
peroxidase 174
glutathione peroxidase 164
lipoprotein lipase 156
alanine aminotransferase 148
protein kinase C 137
phosphodiesterase 127
methylenetetrahydrofolate reductase 126
methylenetetrahydrofolate reductase 125
luciferase 124
phospholipase A2 124
aspartate aminotransferase 118
caspase-3 113
focal adhesion kinase 109
CAD 107
CAD 107
CAD 107
paraoxonase 106
creatine kinase 102
paraoxonase 93
subtilisin 92
lactate dehydrogenase 92
proprotein convertase 89
AMPK 87
xanthine oxidase 84
lipase 84
calcineurin 82
AMPK 81
3-hydroxy-3-methylglutaryl coenzyme A reductase 80
NOS 79
alkaline phosphatase 77
ATPase 74
angiotensin-converting enzyme 2 69
furin 69
thromboplastin 63
plasmin 62
APC 61
reverse transcriptase 60
guanylate cyclase 58
CD10 55
AST 50
phosphatidylinositol 3-kinase 48
LPL 47
collagenase 46
proteasome 44
gamma-glutamyl transpeptidase 44
cholesterol acyltransferase 43
acetylcholinesterase 38
aldehyde dehydrogenase 38
caspase-1 38
heme oxygenase 38
glutathione S-transferase 38
MAP 35
cystathionine beta-synthase 35
soluble epoxide hydrolase 35
urokinase-type plasminogen activator 34
ceruloplasmin 34
arginase 34
MEK 33
dimethylarginine dimethylaminohydrolase 31
lipoxygenase 29
lecithin:cholesterol acyltransferase 28
alpha-glucosidase 28
phospholipase C 27
CYP7A1 26
cholinesterase 26
trypsin 26
more...
Compound
Clin 5663
glucose 5026
Dec 4290
Cardiol 3788
oxygen 1972
calcium 1867
nitric oxide 1477
DNA 1320
homocysteine 1166
sodium 1140
creatinine 936
water 853
vitamin D 782
Insulin 696
aldosterone 677
salt 639
phosphate 590
Cholesterol 543
acetate 530
arginine 466
TNF 450
potassium 431
iron 394
Dial 342
ATP 331
ethanol 314
methionine 294
ASA 289
nitrogen 280
Estrogen 276
hydrogen 272
Pac 263
sulfate 241
Angiotensin II 239
phosphorus 232
Estrogen 230
cysteine 225
Vitamin D 213
ACS 209
ACS 208
Ang II 202
zinc 198
selenium 196
copper 189
ADP 188
prostacyclin 182
DBP 179
DBP 179
CO2 173
urea 169
DHA 167
nitrate 165
Statin 158
Homocysteine 154
Homocysteine 154
tyrosine 150
EPA 146
Diabetol 138
DHA 133
silver 131
DHA 131
Diabetol 130
ADP 129
ADP 127
serine 126
Metformin 123
Metformin 123
GSH 121
GSH 121
nicotinic acid 120
lysine 119
PMA 118
Optimal 114
silicon 112
PGA 112
Fibrinogen 111
cGMP 110
Sodium 104
Testosterone 100
Testosterone 100
more...