Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0007112 (prostatic adenocarcinoma)
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Human Gene/Protein
TAK1-like 13.6
KLK15 protein 12.6
prostate associated 11.7
prostein 11.6
TGF-beta activated kinase 11.6
PRPSAP1 11.6
pp32r1 11.4
BAIAP2L2 11.3
Dual specificity phosphatase 1 11.3
ANP32C 11.3
SH3GLB2 11.0
TTC7A 10.6
ASB9 10.4
hsp75 10.3
SPAS-1 10.3
AMACR 10.2
gamma-seminoprotein 10.2
PSA3 10.1
PDZD8 9.9
PAP-2a 9.9
prostatic acid phosphatase 9.7
MXI 9.5
PIN4 9.4
ACPP 9.4
prostate specific antigen 9.4
CEACAM4 9.3
NKX3.1 9.3
Filamin B 9.2
TRDV2 9.2
CTNND2 9.1
PKE 9.0
SPAP 8.9
CRIPT 8.9
PAP-2 8.9
prostate-specific antigen 8.9
KLK15 8.8
AT3 8.8
PSAP 8.8
PSTP 8.7
Prostate specific antigen 8.5
AT-1 8.5
Glutathione S-transferase pi 8.5
PRKCE 8.5
ACBP 8.4
FOLH1 8.4
IRF2BP2 8.4
MAGI-2 8.4
delta-catenin 8.4
MSH6 protein 8.3
PSA 8.3
PSP94 8.3
MCFD2 8.2
transmembrane protease, serine 2 8.2
cysteine-rich secretory protein 3 8.1
BAF57 8.1
PRH 8.1
PSMA 8.0
FLNB 8.0
PAT2 8.0
P63 7.9
kallikrein 5 7.9
prostate-specific membrane antigen 7.9
Hes6 7.8
ATBF1 7.8
FBXO11 7.8
TMPRSS2 7.8
MXI1 7.8
ZAR1 7.7
LIP2 7.7
CD168 7.7
Ksp-cadherin 7.6
Sp5 7.6
LIP1 7.6
p69 7.6
Pgp1 7.6
AKR1A1 7.6
DBI 7.6
FLNC 7.6
PIN 7.5
uroplakin II 7.5
NFATC2 7.5
MCAM 7.5
Annexin I 7.4
CAMI 7.4
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein 7.4
ADK 7.4
CK7 7.4
HOXB13 7.3
FLNA 7.3
TXN 7.3
RIG-1 7.3
ARE1 7.3
p63 7.3
Cyclooxygenase-1 7.3
LD5 7.2
CRIg 7.2
pT3 7.2
MAT 7.1
Cyclin-dependent kinase inhibitor 3 7.1
MYLK 7.1
HES5 7.1
Glyceraldehyde 3-phosphate dehydrogenase 7.1
glutathione S-transferase pi 7.1
TARP 7.1
hK3 7.1
crinkled 7.1
AKR1C3 7.1
AGR2 7.1
INT2 7.0
CK20 7.0
ERG 7.0
CDX2 7.0
PAX8 7.0
CaCC 6.9
Hpr 6.9
RRP 6.8
BCO 6.8
IGFR1 6.8
gastricsin 6.8
HAI-1 6.8
napsin A 6.8
ERG1 6.8
PNI 6.7
uroplakin III 6.7
CK4 6.7
PAP 6.7
olfactomedin 4 6.7
HHEX 6.7
HA4 6.7
AKR1C4 6.6
PAX2 6.6
PLA2R 6.6
sodium iodide symporter 6.6
acid phosphatase 6.6
PPX 6.6
SPRY4 6.6
PTEN/MMAC1 6.6
IT1 6.5
SPOP 6.5
cytokeratin 7 6.5
E-like 6.5
ubiquitin protease 6.4
Transforming growth factor alpha 6.4
PC-3 6.4
chromogranin A 6.4
p63) 6.4
SEK 6.3
diazepam binding inhibitor 6.3
ADAMTS1 6.3
ANO1 6.3
seminal plasma protein 6.3
cytokeratin 6.3
KIF5B 6.3
ECGF 6.3
kininase I 6.3
NRXN1 6.3
TA1 6.2
KLK3 6.2
GATA3 6.2
Nuclear protein 6.2
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Disease
Carcinoid tumor of the prostate 13.6
Dysplasia of prostate 13.6
Uterine Carcinosarcoma 13.6
prostatic adenocarcinoma 13.6
Prostatic atrophy 12.6
Nontraumatic subdural hematoma 12.6
Small cell carcinoma of prostate 12.6
Cervical Squamous Cell Carcinoma 12.0
prostate nodule 11.6
High grade prostatic intraepithelial neoplasia 11.1
Other malignant neoplasms 11.0
BCG granuloma 11.0
Other malignant neoplasms 11.0
Spastic quadriparesis 11.0
Paraneoplastic retinopathy 10.8
cancer associated retinopathy 10.4
Nephrogenic adenoma 10.4
Malignant Peripheral Nerve Sheath Tumor 10.3
Invasive Carcinoma 10.1
Omental metastasis 10.1
Papillary adenocarcinoma 9.9
urinary tract neoplasm 9.9
Prostate tumor 9.8
Thyroid Carcinoma 9.8
stage C prostate cancer 9.7
Sclerosing adenosis 9.7
PIN 9.7
stage A prostate cancer 9.6
prostatomegaly 9.6
stage B prostate cancer 9.6
Microlithiasis 9.4
Endometrial Carcinoma 9.3
Endometrioid adenocarcinoma 9.3
Ductal 9.2
adenosis 9.1
Virchow's node 9.1
Endobronchial metastases 9.0
AT3 8.8
AT3 8.8
AT3 8.8
AT3 8.8
AT3 8.8
AT3 8.8
AT3 8.8
AT3 8.8
AT3 8.8
Tumor morphology 8.7
dysbasia 8.7
Erythrodermic psoriasis 8.7
Metastatic adenocarcinoma 8.6
Jacksonian seizures 8.6
prostatic disease 8.5
paraphimosis 8.5
Renal metastasis 8.5
Microinvasive 8.5
carcinoma of unknown origin 8.4
urinary system cancer 8.4
salivary gland adenoid cystic carcinoma 8.3
prostate cancer stage 8.3
PSA 8.3
Eosinophilic pneumonia 8.2
Cystadenocarcinoma 8.2
intestinal neoplasm 8.1
Prostate Cancer 8.1
vasitis 8.0
recurrent prostate cancer 8.0
Spermatic cord 8.0
stage D prostate cancer 7.9
Urinary schistosomiasis 7.9
Large cell neuroendocrine carcinoma 7.9
PIN 7.9
Breast metastases 7.9
hormone refractory prostate cancer 7.9
RS3PE syndrome 7.8
adenomatoid tumor 7.8
adenocarcinoma of unknown primary 7.8
TGCT 7.7
androgen independent prostate cancer 7.7
transitional cell carcinoma 7.7
Benign neoplasms 7.7
Benign neoplasms 7.7
Colorectal adenocarcinoma 7.7
Carcinosarcoma 7.7
adenocarcinoma of the bladder 7.6
Lymphoblastic lymphoma 7.6
Adenocarcinoma 7.6
Localized amyloidosis 7.6
Small cell carcinoma 7.5
Adenosquamous carcinoma 7.5
prostate cancer 7.5
prostatitis 7.5
seminal vesicles 7.5
Pseudolymphoma 7.4
testicular embryonal carcinoma 7.3
prostatic adenoma 7.3
Cranial nerve palsies 7.3
mucinous carcinoma 7.3
ATE 7.3
prostatic obstruction 7.2
cerebral hematoma 7.2
transitional cell carcinoma of the bladder 7.1
squamous cell carcinoma of the penis 7.1
Benign fibrous histiocytoma 7.1
rectal polyp 7.1
Cerebral metastases 7.1
Sarcomatoid carcinoma 7.0
Retinal vein occlusion 7.0
carcinoma of the uterus 7.0
residual cancer 7.0
skin metastases 7.0
papillary tumor 7.0
proctosigmoiditis 7.0
urethral cancer 7.0
Trousseau's syndrome 7.0
squamous cell carcinoma of the anus 7.0
villous adenoma 6.9
Primary leiomyosarcoma 6.9
Bladder neck 6.9
measurable disease 6.9
signet ring cell carcinoma 6.9
blue nevus 6.8
proctitis 6.8
endocrine neoplasm 6.8
Pancoast tumor 6.8
Chronic prostatitis 6.8
linitis plastica 6.8
bone metastases 6.8
Atrophic 6.7
Collet-Sicard syndrome 6.7
carcinoma of the bladder 6.7
Metastatic carcinoma 6.6
adenocarcinoma 6.6
bladder neoplasm 6.6
melanosis coli 6.6
urethra 6.6
neuroendocrine carcinoma 6.5
lymphocele 6.5
refractory cancer 6.5
renal clear cell carcinoma 6.5
Lymph node metastases 6.5
uterine carcinosarcoma 6.5
ovarian serous cystadenocarcinoma 6.4
small bowel adenocarcinoma 6.4
evaluable disease 6.4
Extramammary Paget's disease 6.4
penile cancer 6.3
Hemorrhagic cystitis 6.3
malignant pericardial effusion 6.3
Adenoid cystic carcinoma 6.3
clear cell carcinoma 6.3
lymphoblastoma 6.3
Squamous Cell Carcinoma 6.3
melanosis 6.3
ductal carcinoma in situ 6.2
carcinosarcoma 6.2
adenocarcinoma of the colon 6.2
locally advanced cancer 6.2
Papillary carcinoma 6.1
comedo 6.1
hydroureteronephrosis 6.0
more...
Symptom
swollen prostate 12.0
prostatism 8.0
frequent urination 7.8
penile lesion 7.4
Urinary symptoms 7.3
dysuria 7.0
hot flashes 6.5
leg edema 6.5
bone pain 6.5
urinary frequency 6.5
loin pain 6.3
anal pain 5.7
testicular pain 5.2
renal colic 4.9
Halo 4.7
hot flushes 4.3
consciousness disturbance 3.9
blurred vision 3.6
chills 3.5
flank pain 3.5
abnormal gait 3.5
decreased appetite 3.4
night sweats 3.4
dental pain 3.4
dysarthria 3.3
shortness of breath 3.2
pelvic pain 3.2
nausea and vomiting 2.9
numbness 2.8
back pain 2.8
neuralgia 2.8
hip pain 2.8
cerebellar ataxia 2.8
paresis 2.7
hemiplegia 2.6
leg pain 2.6
fever of unknown origin 2.6
flushing 2.5
nausea 2.5
stridor 2.4
tachypnea 2.3
constipation 2.3
asthenia 2.2
paraparesis 2.2
anorexia 2.2
dyspnea 2.1
discomfort 2.1
knee pain 2.1
hepatomegaly 2.1
discomfort 2.0
polyuria 2.0
abdominal pain 2.0
colic 2.0
low back pain 1.9
ophthalmoplegia 1.9
exertional dyspnea 1.9
vertigo 1.8
arthralgia 1.8
Ill 1.7
neck pain 1.7
vomiting 1.6
hepatosplenomegaly 1.5
splenomegaly 1.3
analgesia 1.1
cachexia 1.1
lethargy 1.1
chest pain 1.1
pain 1.1
cough 1.1
erythema 0.9
headache 0.8
weakness 0.7
hypercapnia 0.6
ataxia 0.6
insomnia 0.2
thinning 0.1
diarrhea -0.2
anesthesia -0.3
fatigue -0.5
starvation -1.0
seizures -1.1
collapse -1.2
Drug
Serum gonadotrophin 9.7
Eulexin 9.4
Plasmanate 9.2
Estracyt 9.0
Estracyt 8.9
Menogaril 8.6
ProstaScint 8.6
Diastase 8.5
R1881 8.2
Lupron 7.5
Velban 7.4
Zoladex 7.2
URF 7.1
Teniposide 7.0
Zoladex 6.9
Morphine sulfate 6.7
CET 6.3
Finasteride 5.8
Encore 5.7
CDX 5.6
Taxotere 5.3
Mirtazapine 5.3
CDX 5.2
Ketoconazole 5.1
Docetaxel 5.1
Ipilimumab 4.9
Adriamycin 4.9
Epigallocatechin 4.8
AHF 4.7
Thyroglobulin 4.6
ETS 4.6
Denosumab 4.5
Estrogens 4.5
Cremophor EL 4.3
Raloxifene 4.1
CTX 4.1
Luteinizing 3.6
ADM 3.6
Paraffin 3.5
Pronase 3.2
GEO 3.0
CPT-11 2.7
EE2 2.7
ADR 2.6
ACT 2.5
DHT 2.5
DHT 2.4
CTX 2.1
CAM 2.1
Retinoic acid 1.9
Kenyan 1.8
ROC 1.7
p75 1.7
ICI 1.2
CTX 1.1
Indomethacin 1.0
DNase I 0.6
Biopolymers 0.5
ENT 0.5
citric acid 0.3
Leaf 0.2
vitamin E -0.5
lysine -1.2
CSF -1.3
Dermatol -1.4
Enzyme
alpha-methylacyl-CoA racemase 10.1
prostate-specific antigen 8.9
prostate-specific membrane antigen 7.9
MAT 7.1
3alpha-hydroxysteroid dehydrogenase 7.1
gastricsin 7.0
MAT 6.9
20alpha-hydroxysteroid dehydrogenase 6.6
acid phosphatase 6.5
spermine synthase 6.1
aminopeptidase P 5.9
polyamine oxidase 5.7
AMP-activated kinase 5.7
5alpha-reductase 5.1
5alpha-reductase 5.1
matriptase 5.0
CPN 4.8
S-adenosylmethionine decarboxylase 4.8
lactic acid dehydrogenase 4.8
lactic acid dehydrogenase 4.7
matriptase 4.6
aldehyde reductase 4.6
aldehyde reductase 4.6
aldehyde reductase 4.5
matrix metalloproteinase 2 4.4
15-lipoxygenase 4.4
HDR 4.4
MDP 4.2
lactic acid dehydrogenase 4.0
leucine aminopeptidase 3.9
cathepsin D 3.9
ornithine decarboxylase 3.5
enolase 3.3
tissue kallikrein 3.3
asparaginase 3.2
CD10 3.1
TOR 3.1
sialyltransferase 3.0
sialyltransferase 3.0
sialyltransferase 3.0
dipeptidyl peptidase IV 2.9
TdT 2.7
PRE 2.7
alkaline phosphatase 2.6
creatine kinase 2.6
transglutaminase 2.3
topoisomerase 2.3
adenosine deaminase 2.3
adenosine deaminase 2.2
collagenase 2.2
urokinase-type plasminogen activator 2.2
myosin light chain kinase 2.2
kallikrein 2.0
topoisomerase 2.0
thyroid peroxidase 2.0
ribonuclease 1.9
aldose reductase 1.9
ribonuclease 1.9
MMP-3 1.9
lysozyme 1.8
NOS 1.8
arginase 1.7
cathepsin B 1.6
MMP 1.5
pepsin 1.5
lipoxygenase 1.5
plasmin 1.5
transcriptase 1.4
neuraminidase 1.4
CPR 1.2
reverse transcriptase 1.2
APC 1.2
RNase 1.2
tissue plasminogen activator 1.1
lactate dehydrogenase 1.1
peroxidase 1.1
RNase 1.0
NQO1 1.0
AMPK 1.0
AMP-activated protein kinase 0.9
thromboplastin 0.9
ERK 0.9
trypsin 0.8
glutathione S-transferase 0.7
thymidine kinase 0.7
luciferase 0.7
beta-glucuronidase 0.7
succinate dehydrogenase 0.6
cdc2 0.6
MEK 0.4
elastase 0.4
ACE 0.4
alcohol dehydrogenase 0.4
proteasome 0.4
NADPH oxidase 0.3
glutathione peroxidase 0.2
NADPH oxidase 0.1
RNA polymerase 0.1
mitogen-activated protein kinase 0.0
AMPK -0.0
PARP -0.1
phospholipase A2 -0.2
beta-galactosidase -0.2
protein kinase C -0.4
thrombin -0.4
calcineurin -0.5
caspase-3 -0.5
catalase -0.6
endonuclease -0.6
phosphodiesterase -0.6
adenylate cyclase -0.6
protein kinase -0.7
aspartate aminotransferase -0.8
ATPase -0.8
alanine aminotransferase -1.1
superoxide dismutase -1.2
Compound
15S-hydroxyeicosatrienoic acid 11.3
G 33 11.0
Pachymic acid 9.8
Estracyt 9.2
Estracyt 9.2
2,6-piperidinedione 8.8
2,6-piperidinedione 8.7
PC-5 8.6
Olsalazine 8.5
Prednimustine 8.1
Estramustine 8.0
DBI 7.5
X 14 7.5
PIN 7.5
IDC 7.3
Androgen 7.2
Morphine sulfate 6.9
Actinomycin 6.9
PAP 6.7
DBI 6.7
MGBG 6.7
MGBG 6.7
Leuprolide 6.6
Formononetin 6.6
Naphthol Yellow S 6.5
androstane-3,17-dione 6.5
PAP 6.5
PAP 6.5
Florid 6.4
PAP 6.4
Nobiletin 6.1
Tegafur 6.1
N-(4-hydroxyphenyl)retinamide 6.1
8-hydroxyguanosine 6.0
androstan-3-one 5.9
FTA 5.9
Colcemid 5.8
isopentane 5.7
Tegafur 5.7
CCC 5.7
DES 5.7
Keratin 5.6
Cyproterone acetate 5.6
Hypericin 5.4
AAB 5.4
AAB 5.4
Deoxyribonucleic acid 5.3
NBC 5.2
Ketoconazole 5.2
Docetaxel 5.2
Thymoquinone 5.1
Hydroxyurea 5.0
Epirubicin 4.9
5-HTP 4.9
5-HTP 4.9
5-Azacytidine 4.8
CCNU 4.8
Naringin 4.7
DPN 4.7
B17 4.5
DAP 4.5
DAP 4.5
BCNU 4.5
25-dihydroxycholecalciferol 4.4
ACI 4.4
Hoe 4.4
DBD 4.4
Neomycin 4.3
Hematoxylin 4.3
Raloxifene 4.2
Methylglyoxal 4.2
DFS 4.2
TNM 4.2
Luteolin 4.2
MNNG 4.1
CTX 4.1
A 71 4.1
bis(2-chloroethyl) 4.1
Polyamine 4.0
Adriamycin 4.0
Epigallocatechin 4.0
CPA 4.0
Lea 4.0
DOP 4.0
Pioglitazone 3.9
CPA 3.9
Chondroitin sulfate 3.9
VM-26 3.9
HPC 3.8
CPA 3.8
Warfarin 3.8
HPC 3.8
Suramin 3.8
CoA 3.8
Tamoxifen 3.7
bis(2-chloroethyl) 3.7
Tin 3.7
Celecoxib 3.7
Estrogen 3.7
Coumarin 3.7
Androstenedione 3.7
Octreotide 3.7
PSP 3.6
bis(2-chloroethyl) 3.6
5-FU 3.6
CPA 3.6
Bromocriptine 3.5
Melanin 3.5
Emodin 3.5
MTX 3.5
Tamoxifen 3.4
PNA 3.3
Methotrexate 3.3
Luminal 3.3
DIC 3.2
DAB 3.2
BUdR 3.1
Testosterone 3.0
Testosterone 3.0
DDP 3.0
Estradiol 3.0
androstane 3.0
COX 3.0
PAS 3.0
Actinomycin D 3.0
5-hydroxytryptophan 2.9
8-OHdG 2.9
CAP 2.9
Gemcitabine 2.9
formaldehyde 2.9
Gemcitabine 2.9
Ibuprofen 2.8
DOPAC 2.8
Choline 2.7
iodine 2.7
CAP 2.7
CPT-11 2.7
dUTP 2.7
Colchicine 2.6
Estrogen 2.6
Genistein 2.6
PPI 2.6
TAR 2.5
PVA 2.5
GalNAc 2.5
Resveratrol 2.5
rubidium 2.5
Vasopressin 2.5
Calcitonin 2.4
DTPA 2.4
DCC 2.4
His 2.3
phosphocreatine 2.3
acetate 2.3
CAM 2.3
TBI 2.2
Capsaicin 2.2
DHT 2.2
Fibrinogen 2.2
MMC 2.2
more...